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O30564 (NAGB_BORBU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucosamine-6-phosphate deaminase
EC=3.5.99.6
Alternative name(s):
GlcN6P deaminase
Short name=GNPDA
Glucosamine-6-phosphate isomerase
Gene names
Name:nagB
Ordered Locus Names:BB_0152
OrganismBorrelia burgdorferi (Lyme disease spirochete)
Taxonomic identifier139 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia burgdorferi group

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion By similarity. HAMAP MF_01241

Catalytic activity

D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3. HAMAP MF_01241

Enzyme regulation

Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P) By similarity. HAMAP MF_01241

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5. HAMAP MF_01241

Sequence similarities

Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Glucosamine-6-phosphate deaminase HAMAP MF_01241
PRO_0000160137

Sites

Active site721Proton acceptor; for enolization step By similarity
Active site1411For ring-opening step By similarity
Active site1431Proton acceptor; for ring-opening step By similarity
Active site1481For ring-opening step By similarity
Site1511Part of the allosteric site By similarity
Site1581Part of the allosteric site By similarity
Site1601Part of the allosteric site By similarity
Site1611Part of the allosteric site By similarity
Site2541Part of the allosteric site By similarity

Secondary structure

1 ........................................ 268
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O30564 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 9807089FCCC4BD75

FASTA26830,358
        10         20         30         40         50         60 
MRLIIRPTYE DISKWAANHV AQKINEFSPT KENPFILGLP TGSSPIGMYK NLIELNKNKK 

        70         80         90        100        110        120 
ISFQNVITFN MDEYIGIEEN HPESYHSFMW NNFFSHIDIK KENINILNGN ASNLKKECEE 

       130        140        150        160        170        180 
YEKKIKSFGG IMLFVGGIGP DGHIAFNEPG SSLTSRTRIK TLTQDTIIAN SRFFEGDVNK 

       190        200        210        220        230        240 
VPKNALTVGI GTIMDSQEVL IIVNGHNKAR ALKHAIEKGV NHMWTISALQ LHKNAIIVSD 

       250        260 
KNATYELKVG TVEYFNDIER KNFNNDLK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF011226 Genomic DNA. Translation: AAB65253.1.
AE000783 Genomic DNA. Translation: AAC66538.1.
PIRH70118.
RefSeqNP_212286.1. NC_001318.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HN6X-ray2.20A/B/C/D/E/F1-268[»]
ProteinModelPortalO30564.
SMRO30564. Positions 1-262.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000008614; EBBORP00000007944; EBBORG00000008613.
GeneID1194987.
GenomeReviewsGene locus BB_0152 in contig AE000783_GR.
KEGGbbu:BB0152.
NMPDRfig|224326.1.peg.536.
PATRIC20556908. VBIBorBur75917_0549.
TIGRBB_0152.

Phylogenomic databases

GeneTreeEBGT00050000007325.
HOGENOMHBG725991.
OMAHSFMYNN.
PhylomeDBO30564.
ProtClustDBPRK00443.

Enzyme and pathway databases

BioCycBBUR224326:BB_0152-MONOMER.

Family and domain databases

HAMAPMF_01241. GlcN6P_deamin.
[Tree]
InterProIPR006148. Glc/Gal-6P_isomerase.
IPR004547. Glucosamine6P_isomerase.
IPR018321. Glucosamine6P_isomerase_CS.
[Graphical view]
KOK02564.
PANTHERPTHR11280. NagB. 1 hit.
PfamPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsTIGR00502. NagB. 1 hit.
PROSITEPS01161. GLC_GALNAC_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGB_BORBU
AccessionPrimary (citable) accession number: O30564
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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