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Protein

Bacteriocin enterocin-P

Gene

entP

Organism
Enterococcus faecium (Streptococcus faecium)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Bacteriocin that inhibits the growth of wide range of Gram-positive bacterial species. Does not inhibit the growth of several strains of Gram-negative bacteria.2 Publications

pH dependencei

Stable between pH 3.0 and pH 7.0.1 Publication

Temperature dependencei

Thermostable, retains activity after heating at 100 and 121 degrees Celsius.1 Publication

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.24.1.10. the pediocin (pediocin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin enterocin-P
Gene namesi
Name:entPImported
OrganismiEnterococcus faecium (Streptococcus faecium)
Taxonomic identifieri1352 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_500005322828 – 71Bacteriocin enterocin-PAdd BLAST44

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 43By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliO30434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Sequence analysis

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O30434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKKLFSLAL IGIFGLVVTN FGTKVDAATR SYGNGVYCNN SKCWVNWGEA
60 70
KENIAGIVIS GWASGLAGMG H
Length:71
Mass (Da):7,552
Last modified:January 1, 1998 - v1
Checksum:i8CAC2BF6EEF59978
GO

Mass spectrometryi

Molecular mass is 4701.25 Da from positions 28 - 71. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005726 Genomic DNA. Translation: AAC45870.1.
DQ867124 Genomic DNA. Translation: ABI29856.1.
DQ867125 Genomic DNA. Translation: ABI29857.1.
FJ416486 Genomic DNA. Translation: ACJ46052.1.
FJ416487 Genomic DNA. Translation: ACJ46053.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005726 Genomic DNA. Translation: AAC45870.1.
DQ867124 Genomic DNA. Translation: ABI29856.1.
DQ867125 Genomic DNA. Translation: ABI29857.1.
FJ416486 Genomic DNA. Translation: ACJ46052.1.
FJ416487 Genomic DNA. Translation: ACJ46053.1.

3D structure databases

ProteinModelPortaliO30434.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.24.1.10. the pediocin (pediocin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETCP_ENTFC
AccessioniPrimary (citable) accession number: O30434
Secondary accession number(s): Q0GFE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 1, 1998
Last modified: October 5, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.