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O30409 (TYCC_BREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrocidine synthase 3
Alternative name(s):
Tyrocidine synthase III

Including the following 6 domains:

  1. ATP-dependent asparagine adenylase
    Short name=AsnA
    Alternative name(s):
    Asparagine activase
  2. ATP-dependent glutamine adenylase
    Short name=GlnA
    Alternative name(s):
    Glutamine activase
  3. ATP-dependent tyrosine adenylase
    Short name=TyrA
    Alternative name(s):
    Tyrosine activase
  4. ATP-dependent valine adenylase
    Short name=ValA
    Alternative name(s):
    Valine activase
  5. ATP-dependent ornithine adenylase
    Short name=OrnA
    Alternative name(s):
    Ornithine activase
  6. ATP-dependent leucine adenylase
    Short name=LeuA
    Alternative name(s):
    Leucine activase
Gene names
Name:tycC
OrganismBrevibacillus parabrevis
Taxonomic identifier54914 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length6486 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.

Cofactor

Binds 6 phosphopantetheines covalently By similarity.

Pathway

Antibiotic biosynthesis; tyrocidine biosynthesis.

Subunit structure

Large multienzyme complex of TycA, TycB and TycC.

Domain

Consists of six modules, and harbors a putative thioesterase domain at its C-terminal end. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

Miscellaneous

Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino acids in the growth medium.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Contains 6 acyl carrier domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 64866486Tyrocidine synthase 3
PRO_0000193095

Regions

Domain970 – 103768Acyl carrier 1
Domain2007 – 207468Acyl carrier 2
Domain3045 – 311268Acyl carrier 3
Domain4080 – 414768Acyl carrier 4
Domain5124 – 519168Acyl carrier 5
Domain6167 – 623468Acyl carrier 6
Region466 – 1038573Domain 1 (asparagine-activating)
Region1521 – 2070550Domain 2 (glutamine-activating)
Region2536 – 3113578Domain 3 (tyrosine-activating)
Region3590 – 4149560Domain 4 (valine-activating)
Region4606 – 5203598Domain 5 (ornithine-activating)
Region5658 – 6245588Domain 6 (leucine-activating)

Amino acid modifications

Modified residue10001O-(pantetheine 4'-phosphoryl)serine By similarity
Modified residue20371O-(pantetheine 4'-phosphoryl)serine By similarity
Modified residue30751O-(pantetheine 4'-phosphoryl)serine
Modified residue41101O-(pantetheine 4'-phosphoryl)serine By similarity
Modified residue51541O-(pantetheine 4'-phosphoryl)serine By similarity
Modified residue61971O-(pantetheine 4'-phosphoryl)serine By similarity

Secondary structure

1 .............................................................................. 6486
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O30409 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4934900AF07DF786

FASTA6,486724,033
        10         20         30         40         50         60 
MKKQENIAKI YPLTPLQEGM LFHAVTDTGS SAYCLQMSAT IEGDFHLPLF EKSLNKLVEN 

        70         80         90        100        110        120 
YEVLRTAFVY QNMQRPRQVV FKERKVTVPC ENIAHLPSAE QDAYIQAYTK QHHAFDLTKD 

       130        140        150        160        170        180 
NLMKAAIFQT AENKYRLVWA FHHIIVDGWT LGVLLHKLLT YYAALRKGEP IPREATKPYS 

       190        200        210        220        230        240 
EYIKWLDKQN KDEALAYWQN YLAGYDHQAA FPKKKLGTEA SRYEHVEAMF TIAPEKTQQL 

       250        260        270        280        290        300 
IQIANQNQAT MSSVFQALWG ILASTYKNAD DVVFGSVVSG RPPQIQGIES MVGLFINTIP 

       310        320        330        340        350        360 
TRVQTNKQQT FSELLQTVQK QALASATYDF APLYEIQSTT VLKQELIDHL VTFENYPDHS 

       370        380        390        400        410        420 
MKHLEESLGF QFTVESGDEQ TSYDLNVVVA LAPSNELYVK LSYNAAVYES SFVNRIEGHL 

       430        440        450        460        470        480 
RTVIDQVIGN PHVHLHEIGI ITEEEKQQLL VAYNDTAAEY PRDKTIFELI AEQASRTPAK 

       490        500        510        520        530        540 
AAVVCGEDTL TYQELMERSA QLANALREKG IASGSIVSIM AEHSLELIVA IMAVLRSGAA 

       550        560        570        580        590        600 
YLPIDPEYPQ DRIQYLLDDS QTTLLLTQSH LQPNIRFAGS VLYLDDRSLY EGGSTSFAPE 

       610        620        630        640        650        660 
SKPDDLAYMI YTSGSTGNPK GAMITHQGLV NYIWWANKVY VQGEAVDFPL YSSISFDLTV 

       670        680        690        700        710        720 
TSIFTPLLSG NTIHVYRGAD KVQVILDIIK DNKVGIIKLT PTHLKLIEHI DGKASSIRRF 

       730        740        750        760        770        780 
IVGGENLPTK LAKQIYDHFG ENVQIFNEYG PTETVVGCMI YLYDPQTTTQ ESVPIGVPAD 

       790        800        810        820        830        840 
NVQLYLLDAS MQPVPVGSLG EMYIAGDGVA KGYFNRPELT KEKFIDNPFR PGTKMYRTGD 

       850        860        870        880        890        900 
LAKWLPDGNM EYAGRMDYQV KIRGHRIEMG EIETRLTQHE AVKEAVVIVE KDESGQNVLY 

       910        920        930        940        950        960 
AYLVSERELT VAELREFLGR TLPSYMIPSF FIRLAEIPLT ANGKVERKKL PKPAGAVVTG 

       970        980        990       1000       1010       1020 
TAYAAPQNEI EAKLAEIWQQ VLGISQVGIH DDFFDLGGHS LKAMTVVFQV SKALEVELPV 

      1030       1040       1050       1060       1070       1080 
KALFEHPTVA ELARFLSRSE KTEYTAIQPV AAQEFYPVSS AQKRMYILQQ FEGNGISYNI 

      1090       1100       1110       1120       1130       1140 
SGAILLEGKL DYARFASAVQ QLAERHEALR TSFHRIDGEP VQKVHEEVEV PLFMLEAPED 

      1150       1160       1170       1180       1190       1200 
QAEKIMREFV RPFDLGVAPL MRTGLLKLGK DRHLFLLDMH HIISDGVSSQ ILLREFAELY 

      1210       1220       1230       1240       1250       1260 
QGADLQPLSL QYKDFAAWQN ELFQTEAYKK QEQHWLNTFA DEIPLLNLPT DYPRPSVQSF 

      1270       1280       1290       1300       1310       1320 
AGDLVLFAAG KELLERLQQV ASETGTTLYM ILLAAYNVLL SKYTGQEDII VGTPVAGRSH 

      1330       1340       1350       1360       1370       1380 
ADVENIMGIF VNTLALRNQP ASSKTFAQFL QEVKQNALAA YDHQDYPFEE LVEKLAIQRD 

      1390       1400       1410       1420       1430       1440 
ISRNPLFDTL FSLENANQQS LAIAELTASP YELFNKISKF DLALNASESP ADIQFQLTFA 

      1450       1460       1470       1480       1490       1500 
TKLFKKETVE RMARHYLEIL RWISEQPTAS LADIDMMTEA EKRTLLLNVN DTFVERTAAT 

      1510       1520       1530       1540       1550       1560 
ALHQLVEEQA ARTPDEVAVV YEEYALTYRE LNARANQLAR LLRSHGTGPD TLIGIMVDRS 

      1570       1580       1590       1600       1610       1620 
PGMVVGMLAV LKAGGAYTPI DPSYPPERIQ YMLSDSQAPI LLTQRHLQEL AAYQGEIIDV 

      1630       1640       1650       1660       1670       1680 
DEEAIYTGAD TNLDNVAGKD DLAYVIYTSG STGNPKGVMI SHQAICNHML WMRETFPLTT 

      1690       1700       1710       1720       1730       1740 
EDAVLQKTPF SFDASVWEFY LPLITGGQLV LAKPDGHRDI AYMTRLIRDE KITTLQMVPS 

      1750       1760       1770       1780       1790       1800 
LLDLVMTDPG WSACTSLQRV FCGGEALTPA LVSRFYETQQ AQLINLYGPT ETTIDATYWP 

      1810       1820       1830       1840       1850       1860 
CPRQQEYSAI PIGKPIDNVR LYVVNASNQL QPVGVAGELC IAGDGLARGY WQREELTKAS 

      1870       1880       1890       1900       1910       1920 
FVDNPFEPGG TMYRTGDMVR YLPDGHIEYL GRIDHQVKIR GHRIELGEIE ATLLQHEAVK 

      1930       1940       1950       1960       1970       1980 
AVVVMARQDG KGQNSLYAYV VAEQDIQTAE LRTYLSATLP AYMVPSAFVF LEQLPLSANG 

      1990       2000       2010       2020       2030       2040 
KVDRKALPQP EDAAASAAVY VAPRNEWEAK LAAIWESVLG VEPIGVHDHF FELGGHSLKA 

      2050       2060       2070       2080       2090       2100 
MHVISLLQRS FQVDVPLKVL FESPTIAGLA PLVAAARKGT YTAIPPVEKQ EYYPVSAAQK 

      2110       2120       2130       2140       2150       2160 
RMFILQQMEG AGISYNMPGF MYLDGKLDTE RLQQALKSLV QRHESLRTSF HSVQGETVQR 

      2170       2180       2190       2200       2210       2220 
VHDDVDLAIS FGEATEAETR QIAEQFIQPF DLGTAPLLRA GLIKLAPERH LFMLDLHHIV 

      2230       2240       2250       2260       2270       2280 
VDGVSIGLLI EEFAQLYHGE ELPALRIQYK DFAKWQQDWF QTEEFAEQEA YWLNTFTGEI 

      2290       2300       2310       2320       2330       2340 
PVLNLPTDYP RPSVKSFAGD RFVFGSGTAL PKQLHQLAQE TGTTLYMVLL AAYNVLLSKY 

      2350       2360       2370       2380       2390       2400 
SRQEDIIVGA PTAGRSHAET ESIVGMFVNT LALRNEPAGG KTFRDFLAEV KINTLGAFEH 

      2410       2420       2430       2440       2450       2460 
QDYPLDELVD KLDMQRDLSR NPLFDTVFIL QNMEQKPFEM EQLTITPYSA EVKQAKFDLS 

      2470       2480       2490       2500       2510       2520 
LEAYEENAEI IFSLDYSTKL FSRETIEKIA THFIQILRAV IAEPEMPLSE ITMLTEAEKQ 

      2530       2540       2550       2560       2570       2580 
RLLVDFNGAH KDFPQNKTLQ ALFEEQAEKS PQATAVEISG QPLSYQELNE RANQLAATLR 

      2590       2600       2610       2620       2630       2640 
ERGVQPDQPV GIMANRSVEM VVGILAILKA GGAYVPIDPE YPEERVAYML TDCQARLVLT 

      2650       2660       2670       2680       2690       2700 
QKHLGAKLGS SVTAECLYLD DESNYGVHRS NLQPINTASD LAYIIYTSGT TGKPKGVMVE 

      2710       2720       2730       2740       2750       2760 
HRGIVNNVLW KKAEYQMKVG DRSLLSLSFA FDAFVLSFFT PVLSGATVVL AEDEEAKDPV 

      2770       2780       2790       2800       2810       2820 
SLKKLIAASR CTLMTGVPSL FQAILECSTP ADIRPLQTVT LGGEKITAQL VEKCKQLNPD 

      2830       2840       2850       2860       2870       2880 
LVIVNEYGPT ESSVVATWQR LAGPDAAITI GRPIANTSLY IVNQYHQLQP IGVVGEICIG 

      2890       2900       2910       2920       2930       2940 
GRGLARGYWN KPALTEEKFV SHPFAAGERM YKTGDLGKWL PDGTIEYIGR IDEQVKVRGY 

      2950       2960       2970       2980       2990       3000 
RIEIGEIESA LLAAEKLTAA VVVVYEDQLG QSALAAYFTA DEQLDVTKLW SHLSKRLPSY 

      3010       3020       3030       3040       3050       3060 
MIPAHFVQLD QLPLTPNGKV DKKALPKPEG KPVTEAQYVA PTNAVESKLA EIWERVLGVS 

      3070       3080       3090       3100       3110       3120 
GIGILDNFFQ IGGHSLKAMA VAAQVHREYQ VELPLKVLFA QPTIKALAQY VATSGKETYV 

      3130       3140       3150       3160       3170       3180 
PIEPAPLQEY YPVSSAQKRM YVLRQFADTG TVYNMPSALY IEGDLDRKRF EAAIHGLVER 

      3190       3200       3210       3220       3230       3240 
HESLRTSFHT VNGEPVQRVH EHVELNVQYA EVTEAQVEPT VESFVQAFDL TKAPLLRVGL 

      3250       3260       3270       3280       3290       3300 
FKLAAKRHLF LLDMHHIISD GVSAGIIMEE FSKLYRGEEL PALSVHYKDF AVWQSELFQS 

      3310       3320       3330       3340       3350       3360 
DVYTEHENYW LNAFSGDIPV LNLPADFSRP LTQSFEGDCV SFQADKALLD DLHKLAQESQ 

      3370       3380       3390       3400       3410       3420 
STLFMVLLAA YNVLLAKYSG QEDIVVGTPI AGRSHADIEN VLGMFVNTLA LRNYPVETKH 

      3430       3440       3450       3460       3470       3480 
FQAFLEEVKQ NTLQAYAHQD YPFEALVEKL DIQRDLSRNP LFDTMFILQN LDQKAYELDG 

      3490       3500       3510       3520       3530       3540 
LKLEAYPAQA GNAKFDLTLE AHEDETGIHF ALVYSTKLFQ RESIERMAGH FLQVLRQVVA 

      3550       3560       3570       3580       3590       3600 
DQATALREIS LLSEEERRIV TVDFNNTFAA YPRDLTIQEL FEQQAAKTPE HAAVVMDGQM 

      3610       3620       3630       3640       3650       3660 
LTYRELNEKA NQLAHVLRQN GVGKESIVGL LADRSLEMIT GIMGILKAGG AYLGLDPEHP 

      3670       3680       3690       3700       3710       3720 
SERLAYMLED GGVKVVLVQK HLLPLVGEGL MPIVLEEESL RPEDCGNPAI VNGASDLAYV 

      3730       3740       3750       3760       3770       3780 
MYTSGSTGKP KGVMVEHRNV TRLVMHTNYV QVRESDRMIQ TGAIGFDAMT FEIFGALLHG 

      3790       3800       3810       3820       3830       3840 
ASLYLVSKDV LLDAEKLGDF LRTNQITTMW LTSPLFNQLS QDNPAMFDSL RALIVGGEAL 

      3850       3860       3870       3880       3890       3900 
SPKHINRVKS ALPDLEIWNG YGPTENTTFS TCYLIEQHFE EQIPIGKPIA NSTAYIVDGN 

      3910       3920       3930       3940       3950       3960 
NQPQPIGVPG ELCVGGDGVA RGYVNKPELT AEKFVPNPFA PGETMYRTGD LARWLPDGTI 

      3970       3980       3990       4000       4010       4020 
EYLGRIDQQV KIRGYRIELG EIETVLSQQA QVKEAVVAVI EEANGQKALC AYFVPEQAVD 

      4030       4040       4050       4060       4070       4080 
AAELREAMSK QLPGYMVPAY YVQMEKLPLT ANGKVDRRAL PQPSGERTTG SAFVAAQNDT 

      4090       4100       4110       4120       4130       4140 
EAKLQQIWQE VLGIPAIGIH DNFFEIGGHS LKAMNVITQV HKTFQVELPL KALFATPTIH 

      4150       4160       4170       4180       4190       4200 
ELAAHIAESA FEQFETIQPV EPAAFYPVSF AQKRMYILHQ FEGSGISYNV PSVLVLEGKL 

      4210       4220       4230       4240       4250       4260 
DYDRFAAAIQ SLVKRHESLR TSFHSVNGEP LQRVHPDVEL PVRLLEATED QSESLIQELI 

      4270       4280       4290       4300       4310       4320 
QPFDLEIAPL FRVNLIKLGA ERHLFFMDMH HIISDGVSLA VIVEEIASLY AGKQLSDLRI 

      4330       4340       4350       4360       4370       4380 
QYKDFAVWQT KLAQSDRFQK QEDFWTRTFA GEIPLLNLPH DYPRPSVQSF DGDTVALGTG 

      4390       4400       4410       4420       4430       4440 
HHLLEQLRKL AAETGTTLFM VLLAAYHVLL SKYAGQEEIV VGTPIAGRSH ADVERIVGMF 

      4450       4460       4470       4480       4490       4500 
VNTLALKNTA AGSLSFRAFL EDVKQNALHA FEHQDYPFEH LVEKLQVRRD LSRNPLFDTM 

      4510       4520       4530       4540       4550       4560 
FSLGLAESAE GEVADLKVSP YPVNGHIAKF DLSLDAMEKQ DGLLVQFSYC TKLFAKETVD 

      4570       4580       4590       4600       4610       4620 
RLAAHYVQLL QTITADPDIE LARISVLSKA ETEHMLHSFL ATKTAYPTDK TFQKLFEEQV 

      4630       4640       4650       4660       4670       4680 
EKTPNEIAVL FGNEQLTYQE LNAKANQLAR VLRRKGVKPE STVGILVDRS LYMVIGMLAV 

      4690       4700       4710       4720       4730       4740 
LKAGGTFVPI DPDYPLERQA FMLEDSEAKL LLTLQKMNSQ VAFPYETFYL DTETVDQEET 

      4750       4760       4770       4780       4790       4800 
GNLEHVAQPE NVAYIIYTSG TTGKPKGVVI EHRSYANVAF AWKDEYHLDS FPVRLLQMAS 

      4810       4820       4830       4840       4850       4860 
FAFDVSTGDF ARALLTGGQL VICPNGVKMD PASLYETIRR HEITIFEATP ALIMPLMHYV 

      4870       4880       4890       4900       4910       4920 
YENELDMSQM KLLILGADSC PAEDFKTLLA RFGQKMRIIN SYGVTEACID TSYYEETDVT 

      4930       4940       4950       4960       4970       4980 
AIRSGTVPIG KPLPNMTMYV VDAHLNLQPV GVVGELCIGG AGVARGYLNR PELTEEKFVP 

      4990       5000       5010       5020       5030       5040 
NPFAPGERLY RTGDLAKWRA DGNVEFLGRN DHQVKIRGVR IELGEIETQL RKLDGITEAV 

      5050       5060       5070       5080       5090       5100 
VVAREDRGQE KELCAYVVAD HKLDTAELRA NLLKELPQAM IPAYFVTLDA LPLTANGKVD 

      5110       5120       5130       5140       5150       5160 
RRSLPAPDVT MLRTTEYVAP RSVWEARLAQ VWEQVLNVPQ VGALDDFFAL GGHSLRAMRV 

      5170       5180       5190       5200       5210       5220 
LSSMHNEYQV DIPLRILFEK PTIQELAAFI EETAKGNVFS IEPVQKQAYY PVSSAQKRMY 

      5230       5240       5250       5260       5270       5280 
ILDQFEGVGI SYNMPSTMLI EGKLERTRVE AAFQRLIARH ESLRTSFAVV NGEPVQNIHE 

      5290       5300       5310       5320       5330       5340 
DVPFALAYSE VTEQEARELV SSLVQPFDLE VAPLIRVSLL KIGEDRYVLF TDMHHSISDG 

      5350       5360       5370       5380       5390       5400 
VSSGILLAEW VQLYQGDVLP ELRIQYKDFA VWQQEFSQSA AFHKQEAYWL QTFADDIPVL 

      5410       5420       5430       5440       5450       5460 
NLPTDFTRPS TQSFAGDQCT IGAGKALTEG LHQLAQATGT TLYMVLLAAY NVLLAKYAGQ 

      5470       5480       5490       5500       5510       5520 
EDIIVGTPIT GRSHADLEPI VGMFVNTLAM RNKPQREKTF SEFLQEVKQN ALDAYGHQDY 

      5530       5540       5550       5560       5570       5580 
PFEELVEKLA IARDLSRNPL FDTVFTFQNS TEEVMTLPEC TLAPFMTDET GQHAKFDLTF 

      5590       5600       5610       5620       5630       5640 
SATEEREEMT IGVEYSTSLF TRETMERFSR HFLTIAASIV QNPHIRLGEI DMLLPEEKQQ 

      5650       5660       5670       5680       5690       5700 
ILAGFNDTAV SYALDKTLHQ LFEEQVDKTP DQAALLFSEQ SLTYSELNER ANRLARVLRA 

      5710       5720       5730       5740       5750       5760 
KGVGPDRLVA IMAERSPEMV IGILGILKAG GAYVPVDPGY PQERIQYLLE DSNAALLLSQ 

      5770       5780       5790       5800       5810       5820 
AHLLPLLAQV SSELPECLDL NAELDAGLSG SNLPAVNQPT DLAYVIYTSG TTGKPKGVMI 

      5830       5840       5850       5860       5870       5880 
PHQGIVNCLQ WRRDEYGFGP SDKALQVFSF AFDGFVASLF APLLGGATCV LPQEAAAKDP 

      5890       5900       5910       5920       5930       5940 
VALKKLMAAT EVTHYYGVPS LFQAILDCST TTDFNQLRCV TLGGEKLPVQ LVQKTKEKHP 

      5950       5960       5970       5980       5990       6000 
AIEINNEYGP TENSVVTTIS RSIEAGQAIT IGRPLANVQV YIVDEQHHLQ PIGVVGELCI 

      6010       6020       6030       6040       6050       6060 
GGAGLARGYL NKPELTAEKF VANPFRPGER MYKTGDLVKW RTDGTIEYIG RADEQVKVRG 

      6070       6080       6090       6100       6110       6120 
YRIEIGEIES AVLAYQGIDQ AVVVARDDDA TAGSYLCAYF VAATAVSVSG LRSHLAKELP 

      6130       6140       6150       6160       6170       6180 
AYMIPSYFVE LDQLPLSANG KVDRKALPKP QQSDATTREY VAPRNATEQQ LAAIWQEVLG 

      6190       6200       6210       6220       6230       6240 
VEPIGITDQF FELGGHSLKA TLLIAKVYEY MQIELPLNLI FQYPTIEKVA DFITHKRFES 

      6250       6260       6270       6280       6290       6300 
RYGTAILLNQ ETARNVFCFT PIGAQSVYYQ KLAAEIQGVS LYSFDFIQDD NRMEQYIAAI 

      6310       6320       6330       6340       6350       6360 
TAIDPSGPYT LMGYSSGGNL AFEVAKELEE RGYGVTDIIL FDSYWKDKAI ERTVAETEND 

      6370       6380       6390       6400       6410       6420 
IAQLFAEIGE NTEMFNMTQE DFQLYAANEF VKQSFVRKTV SYVMFHNNLV NTGMTTAAIH 

      6430       6440       6450       6460       6470       6480 
LIQSELEADE EAPVAAKWNE SAWANATQRL LTYSGHGIHS RMLAGDYASQ NASILQNILQ 


ELFILK

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References

[1]"The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains."
Mootz H.D., Marahiel M.A.
J. Bacteriol. 179:6843-6850(1997) [PubMed: 9352938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 8185 / DSM 362 / JCM 20017 / NBRC 3331 / NCDO 717 / NCIMB 8598 / IAM 1031.
[2]"Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases."
Weber T., Baumgartner R., Renner C., Marahiel M.A., Holak T.A.
Structure 8:407-418(2000) [PubMed: 10801488] [Abstract]
Cited for: STRUCTURE BY NMR OF 3032-3113.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF004835 Genomic DNA. Translation: AAC45930.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DNYNMR-A3032-3113[»]
2GDWNMR-A3033-3113[»]
2GDXNMR-A3033-3113[»]
2GDYNMR-A3033-3113[»]
2GE1model-B3033-3113[»]
2JGPX-ray1.85A5116-5633[»]
2K2QNMR-A3033-3112[»]
ProteinModelPortalO30409.
SMRO30409. Positions 1999-2514, 3033-3113, 4069-4147, 5115-5633.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29492N.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR006163. Phsphopanteth-bd.
IPR020806. PKS_PP-bd.
IPR006162. PPantetheine_attach_site.
IPR001031. Thioesterase.
[Graphical view]
Gene3DG3DSA:1.10.1200.10. ACP_like. 6 hits.
PfamPF00501. AMP-binding. 6 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 6 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTSM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMSSF47336. ACP_like. 6 hits.
TIGRFAMsTIGR01733. AA-adenyl-dom. 6 hits.
PROSITEPS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYCC_BREPA
AccessionPrimary (citable) accession number: O30409
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 21, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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