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Protein

Tyrocidine synthase 3

Gene

tycC

Organism
Brevibacillus parabrevis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.

Cofactori

pantetheine 4'-phosphateBy similarityNote: Binds 6 phosphopantetheines covalently.By similarity

Pathwayi: tyrocidine biosynthesis

This protein is involved in the pathway tyrocidine biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway tyrocidine biosynthesis and in Antibiotic biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

SABIO-RKO30409.
UniPathwayiUPA00180.

Protein family/group databases

ESTHERibacbr-tycc. Thioesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrocidine synthase 3
Alternative name(s):
Tyrocidine synthase III
Including the following 6 domains:
ATP-dependent asparagine adenylase
Short name:
AsnA
Alternative name(s):
Asparagine activase
ATP-dependent glutamine adenylase
Short name:
GlnA
Alternative name(s):
Glutamine activase
ATP-dependent tyrosine adenylase
Short name:
TyrA
Alternative name(s):
Tyrosine activase
ATP-dependent valine adenylase
Short name:
ValA
Alternative name(s):
Valine activase
ATP-dependent ornithine adenylase
Short name:
OrnA
Alternative name(s):
Ornithine activase
ATP-dependent leucine adenylase
Short name:
LeuA
Alternative name(s):
Leucine activase
Gene namesi
Name:tycC
OrganismiBrevibacillus parabrevis
Taxonomic identifieri54914 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001930951 – 6486Tyrocidine synthase 3Add BLAST6486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1000O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2037O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3075O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1
Modified residuei4110O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5154O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6197O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRIDEiO30409.

Interactioni

Subunit structurei

Large multienzyme complex of TycA, TycB and TycC.

Protein-protein interaction databases

DIPiDIP-29492N.

Structurei

Secondary structure

16486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3044 – 3057Combined sources14
Turni3064 – 3067Combined sources4
Turni3068 – 3072Combined sources5
Helixi3075 – 3089Combined sources15
Helixi3095 – 3100Combined sources6
Helixi3104 – 3112Combined sources9
Helixi5123 – 5136Combined sources14
Turni5147 – 5151Combined sources5
Helixi5154 – 5168Combined sources15
Helixi5174 – 5179Combined sources6
Helixi5183 – 5192Combined sources10
Beta strandi5208 – 5211Combined sources4
Helixi5214 – 5225Combined sources12
Turni5229 – 5232Combined sources4
Beta strandi5236 – 5242Combined sources7
Helixi5246 – 5259Combined sources14
Helixi5261 – 5264Combined sources4
Beta strandi5265 – 5270Combined sources6
Beta strandi5273 – 5278Combined sources6
Beta strandi5287 – 5290Combined sources4
Helixi5293 – 5302Combined sources10
Beta strandi5315 – 5323Combined sources9
Beta strandi5326 – 5334Combined sources9
Helixi5335 – 5337Combined sources3
Helixi5340 – 5354Combined sources15
Helixi5366 – 5376Combined sources11
Helixi5380 – 5392Combined sources13
Beta strandi5415 – 5422Combined sources8
Helixi5425 – 5438Combined sources14
Helixi5442 – 5458Combined sources17
Beta strandi5463 – 5469Combined sources7
Helixi5475 – 5477Combined sources3
Beta strandi5486 – 5492Combined sources7
Helixi5500 – 5516Combined sources17
Helixi5522 – 5528Combined sources7
Beta strandi5542 – 5548Combined sources7
Beta strandi5558 – 5564Combined sources7
Beta strandi5575 – 5584Combined sources10
Beta strandi5589 – 5596Combined sources8
Turni5597 – 5599Combined sources3
Helixi5602 – 5621Combined sources20
Helixi5627 – 5629Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DNYNMR-A3032-3113[»]
2GDWNMR-A3032-3113[»]
2GDXNMR-A3032-3113[»]
2GDYNMR-A3032-3113[»]
2GE1model-B3033-3113[»]
2JGPX-ray1.85A5116-5633[»]
2K2QNMR-A3033-3112[»]
2MD9NMR-A3032-3113[»]
4MRTX-ray2.00C3038-3113[»]
ProteinModelPortaliO30409.
SMRiO30409.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini970 – 1037Acyl carrier 1PROSITE-ProRule annotationAdd BLAST68
Domaini2007 – 2074Acyl carrier 2PROSITE-ProRule annotationAdd BLAST68
Domaini3045 – 3112Acyl carrier 3PROSITE-ProRule annotationAdd BLAST68
Domaini4080 – 4147Acyl carrier 4PROSITE-ProRule annotationAdd BLAST68
Domaini5124 – 5191Acyl carrier 5PROSITE-ProRule annotationAdd BLAST68
Domaini6167 – 6234Acyl carrier 6PROSITE-ProRule annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni466 – 1038Domain 1 (asparagine-activating)Add BLAST573
Regioni1521 – 2070Domain 2 (glutamine-activating)Add BLAST550
Regioni2536 – 3113Domain 3 (tyrosine-activating)Add BLAST578
Regioni3590 – 4149Domain 4 (valine-activating)Add BLAST560
Regioni4606 – 5203Domain 5 (ornithine-activating)Add BLAST598
Regioni5658 – 6245Domain 6 (leucine-activating)Add BLAST588

Domaini

Consists of six modules, and harbors a putative thioesterase domain at its C-terminal end. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

Sequence similaritiesi

Contains 6 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 6 hits.
PF13193. AMP-binding_C. 6 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 6 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O30409-1 [UniParc]FASTAAdd to basket

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        10         20         30         40         50
MKKQENIAKI YPLTPLQEGM LFHAVTDTGS SAYCLQMSAT IEGDFHLPLF
60 70 80 90 100
EKSLNKLVEN YEVLRTAFVY QNMQRPRQVV FKERKVTVPC ENIAHLPSAE
110 120 130 140 150
QDAYIQAYTK QHHAFDLTKD NLMKAAIFQT AENKYRLVWA FHHIIVDGWT
160 170 180 190 200
LGVLLHKLLT YYAALRKGEP IPREATKPYS EYIKWLDKQN KDEALAYWQN
210 220 230 240 250
YLAGYDHQAA FPKKKLGTEA SRYEHVEAMF TIAPEKTQQL IQIANQNQAT
260 270 280 290 300
MSSVFQALWG ILASTYKNAD DVVFGSVVSG RPPQIQGIES MVGLFINTIP
310 320 330 340 350
TRVQTNKQQT FSELLQTVQK QALASATYDF APLYEIQSTT VLKQELIDHL
360 370 380 390 400
VTFENYPDHS MKHLEESLGF QFTVESGDEQ TSYDLNVVVA LAPSNELYVK
410 420 430 440 450
LSYNAAVYES SFVNRIEGHL RTVIDQVIGN PHVHLHEIGI ITEEEKQQLL
460 470 480 490 500
VAYNDTAAEY PRDKTIFELI AEQASRTPAK AAVVCGEDTL TYQELMERSA
510 520 530 540 550
QLANALREKG IASGSIVSIM AEHSLELIVA IMAVLRSGAA YLPIDPEYPQ
560 570 580 590 600
DRIQYLLDDS QTTLLLTQSH LQPNIRFAGS VLYLDDRSLY EGGSTSFAPE
610 620 630 640 650
SKPDDLAYMI YTSGSTGNPK GAMITHQGLV NYIWWANKVY VQGEAVDFPL
660 670 680 690 700
YSSISFDLTV TSIFTPLLSG NTIHVYRGAD KVQVILDIIK DNKVGIIKLT
710 720 730 740 750
PTHLKLIEHI DGKASSIRRF IVGGENLPTK LAKQIYDHFG ENVQIFNEYG
760 770 780 790 800
PTETVVGCMI YLYDPQTTTQ ESVPIGVPAD NVQLYLLDAS MQPVPVGSLG
810 820 830 840 850
EMYIAGDGVA KGYFNRPELT KEKFIDNPFR PGTKMYRTGD LAKWLPDGNM
860 870 880 890 900
EYAGRMDYQV KIRGHRIEMG EIETRLTQHE AVKEAVVIVE KDESGQNVLY
910 920 930 940 950
AYLVSERELT VAELREFLGR TLPSYMIPSF FIRLAEIPLT ANGKVERKKL
960 970 980 990 1000
PKPAGAVVTG TAYAAPQNEI EAKLAEIWQQ VLGISQVGIH DDFFDLGGHS
1010 1020 1030 1040 1050
LKAMTVVFQV SKALEVELPV KALFEHPTVA ELARFLSRSE KTEYTAIQPV
1060 1070 1080 1090 1100
AAQEFYPVSS AQKRMYILQQ FEGNGISYNI SGAILLEGKL DYARFASAVQ
1110 1120 1130 1140 1150
QLAERHEALR TSFHRIDGEP VQKVHEEVEV PLFMLEAPED QAEKIMREFV
1160 1170 1180 1190 1200
RPFDLGVAPL MRTGLLKLGK DRHLFLLDMH HIISDGVSSQ ILLREFAELY
1210 1220 1230 1240 1250
QGADLQPLSL QYKDFAAWQN ELFQTEAYKK QEQHWLNTFA DEIPLLNLPT
1260 1270 1280 1290 1300
DYPRPSVQSF AGDLVLFAAG KELLERLQQV ASETGTTLYM ILLAAYNVLL
1310 1320 1330 1340 1350
SKYTGQEDII VGTPVAGRSH ADVENIMGIF VNTLALRNQP ASSKTFAQFL
1360 1370 1380 1390 1400
QEVKQNALAA YDHQDYPFEE LVEKLAIQRD ISRNPLFDTL FSLENANQQS
1410 1420 1430 1440 1450
LAIAELTASP YELFNKISKF DLALNASESP ADIQFQLTFA TKLFKKETVE
1460 1470 1480 1490 1500
RMARHYLEIL RWISEQPTAS LADIDMMTEA EKRTLLLNVN DTFVERTAAT
1510 1520 1530 1540 1550
ALHQLVEEQA ARTPDEVAVV YEEYALTYRE LNARANQLAR LLRSHGTGPD
1560 1570 1580 1590 1600
TLIGIMVDRS PGMVVGMLAV LKAGGAYTPI DPSYPPERIQ YMLSDSQAPI
1610 1620 1630 1640 1650
LLTQRHLQEL AAYQGEIIDV DEEAIYTGAD TNLDNVAGKD DLAYVIYTSG
1660 1670 1680 1690 1700
STGNPKGVMI SHQAICNHML WMRETFPLTT EDAVLQKTPF SFDASVWEFY
1710 1720 1730 1740 1750
LPLITGGQLV LAKPDGHRDI AYMTRLIRDE KITTLQMVPS LLDLVMTDPG
1760 1770 1780 1790 1800
WSACTSLQRV FCGGEALTPA LVSRFYETQQ AQLINLYGPT ETTIDATYWP
1810 1820 1830 1840 1850
CPRQQEYSAI PIGKPIDNVR LYVVNASNQL QPVGVAGELC IAGDGLARGY
1860 1870 1880 1890 1900
WQREELTKAS FVDNPFEPGG TMYRTGDMVR YLPDGHIEYL GRIDHQVKIR
1910 1920 1930 1940 1950
GHRIELGEIE ATLLQHEAVK AVVVMARQDG KGQNSLYAYV VAEQDIQTAE
1960 1970 1980 1990 2000
LRTYLSATLP AYMVPSAFVF LEQLPLSANG KVDRKALPQP EDAAASAAVY
2010 2020 2030 2040 2050
VAPRNEWEAK LAAIWESVLG VEPIGVHDHF FELGGHSLKA MHVISLLQRS
2060 2070 2080 2090 2100
FQVDVPLKVL FESPTIAGLA PLVAAARKGT YTAIPPVEKQ EYYPVSAAQK
2110 2120 2130 2140 2150
RMFILQQMEG AGISYNMPGF MYLDGKLDTE RLQQALKSLV QRHESLRTSF
2160 2170 2180 2190 2200
HSVQGETVQR VHDDVDLAIS FGEATEAETR QIAEQFIQPF DLGTAPLLRA
2210 2220 2230 2240 2250
GLIKLAPERH LFMLDLHHIV VDGVSIGLLI EEFAQLYHGE ELPALRIQYK
2260 2270 2280 2290 2300
DFAKWQQDWF QTEEFAEQEA YWLNTFTGEI PVLNLPTDYP RPSVKSFAGD
2310 2320 2330 2340 2350
RFVFGSGTAL PKQLHQLAQE TGTTLYMVLL AAYNVLLSKY SRQEDIIVGA
2360 2370 2380 2390 2400
PTAGRSHAET ESIVGMFVNT LALRNEPAGG KTFRDFLAEV KINTLGAFEH
2410 2420 2430 2440 2450
QDYPLDELVD KLDMQRDLSR NPLFDTVFIL QNMEQKPFEM EQLTITPYSA
2460 2470 2480 2490 2500
EVKQAKFDLS LEAYEENAEI IFSLDYSTKL FSRETIEKIA THFIQILRAV
2510 2520 2530 2540 2550
IAEPEMPLSE ITMLTEAEKQ RLLVDFNGAH KDFPQNKTLQ ALFEEQAEKS
2560 2570 2580 2590 2600
PQATAVEISG QPLSYQELNE RANQLAATLR ERGVQPDQPV GIMANRSVEM
2610 2620 2630 2640 2650
VVGILAILKA GGAYVPIDPE YPEERVAYML TDCQARLVLT QKHLGAKLGS
2660 2670 2680 2690 2700
SVTAECLYLD DESNYGVHRS NLQPINTASD LAYIIYTSGT TGKPKGVMVE
2710 2720 2730 2740 2750
HRGIVNNVLW KKAEYQMKVG DRSLLSLSFA FDAFVLSFFT PVLSGATVVL
2760 2770 2780 2790 2800
AEDEEAKDPV SLKKLIAASR CTLMTGVPSL FQAILECSTP ADIRPLQTVT
2810 2820 2830 2840 2850
LGGEKITAQL VEKCKQLNPD LVIVNEYGPT ESSVVATWQR LAGPDAAITI
2860 2870 2880 2890 2900
GRPIANTSLY IVNQYHQLQP IGVVGEICIG GRGLARGYWN KPALTEEKFV
2910 2920 2930 2940 2950
SHPFAAGERM YKTGDLGKWL PDGTIEYIGR IDEQVKVRGY RIEIGEIESA
2960 2970 2980 2990 3000
LLAAEKLTAA VVVVYEDQLG QSALAAYFTA DEQLDVTKLW SHLSKRLPSY
3010 3020 3030 3040 3050
MIPAHFVQLD QLPLTPNGKV DKKALPKPEG KPVTEAQYVA PTNAVESKLA
3060 3070 3080 3090 3100
EIWERVLGVS GIGILDNFFQ IGGHSLKAMA VAAQVHREYQ VELPLKVLFA
3110 3120 3130 3140 3150
QPTIKALAQY VATSGKETYV PIEPAPLQEY YPVSSAQKRM YVLRQFADTG
3160 3170 3180 3190 3200
TVYNMPSALY IEGDLDRKRF EAAIHGLVER HESLRTSFHT VNGEPVQRVH
3210 3220 3230 3240 3250
EHVELNVQYA EVTEAQVEPT VESFVQAFDL TKAPLLRVGL FKLAAKRHLF
3260 3270 3280 3290 3300
LLDMHHIISD GVSAGIIMEE FSKLYRGEEL PALSVHYKDF AVWQSELFQS
3310 3320 3330 3340 3350
DVYTEHENYW LNAFSGDIPV LNLPADFSRP LTQSFEGDCV SFQADKALLD
3360 3370 3380 3390 3400
DLHKLAQESQ STLFMVLLAA YNVLLAKYSG QEDIVVGTPI AGRSHADIEN
3410 3420 3430 3440 3450
VLGMFVNTLA LRNYPVETKH FQAFLEEVKQ NTLQAYAHQD YPFEALVEKL
3460 3470 3480 3490 3500
DIQRDLSRNP LFDTMFILQN LDQKAYELDG LKLEAYPAQA GNAKFDLTLE
3510 3520 3530 3540 3550
AHEDETGIHF ALVYSTKLFQ RESIERMAGH FLQVLRQVVA DQATALREIS
3560 3570 3580 3590 3600
LLSEEERRIV TVDFNNTFAA YPRDLTIQEL FEQQAAKTPE HAAVVMDGQM
3610 3620 3630 3640 3650
LTYRELNEKA NQLAHVLRQN GVGKESIVGL LADRSLEMIT GIMGILKAGG
3660 3670 3680 3690 3700
AYLGLDPEHP SERLAYMLED GGVKVVLVQK HLLPLVGEGL MPIVLEEESL
3710 3720 3730 3740 3750
RPEDCGNPAI VNGASDLAYV MYTSGSTGKP KGVMVEHRNV TRLVMHTNYV
3760 3770 3780 3790 3800
QVRESDRMIQ TGAIGFDAMT FEIFGALLHG ASLYLVSKDV LLDAEKLGDF
3810 3820 3830 3840 3850
LRTNQITTMW LTSPLFNQLS QDNPAMFDSL RALIVGGEAL SPKHINRVKS
3860 3870 3880 3890 3900
ALPDLEIWNG YGPTENTTFS TCYLIEQHFE EQIPIGKPIA NSTAYIVDGN
3910 3920 3930 3940 3950
NQPQPIGVPG ELCVGGDGVA RGYVNKPELT AEKFVPNPFA PGETMYRTGD
3960 3970 3980 3990 4000
LARWLPDGTI EYLGRIDQQV KIRGYRIELG EIETVLSQQA QVKEAVVAVI
4010 4020 4030 4040 4050
EEANGQKALC AYFVPEQAVD AAELREAMSK QLPGYMVPAY YVQMEKLPLT
4060 4070 4080 4090 4100
ANGKVDRRAL PQPSGERTTG SAFVAAQNDT EAKLQQIWQE VLGIPAIGIH
4110 4120 4130 4140 4150
DNFFEIGGHS LKAMNVITQV HKTFQVELPL KALFATPTIH ELAAHIAESA
4160 4170 4180 4190 4200
FEQFETIQPV EPAAFYPVSF AQKRMYILHQ FEGSGISYNV PSVLVLEGKL
4210 4220 4230 4240 4250
DYDRFAAAIQ SLVKRHESLR TSFHSVNGEP LQRVHPDVEL PVRLLEATED
4260 4270 4280 4290 4300
QSESLIQELI QPFDLEIAPL FRVNLIKLGA ERHLFFMDMH HIISDGVSLA
4310 4320 4330 4340 4350
VIVEEIASLY AGKQLSDLRI QYKDFAVWQT KLAQSDRFQK QEDFWTRTFA
4360 4370 4380 4390 4400
GEIPLLNLPH DYPRPSVQSF DGDTVALGTG HHLLEQLRKL AAETGTTLFM
4410 4420 4430 4440 4450
VLLAAYHVLL SKYAGQEEIV VGTPIAGRSH ADVERIVGMF VNTLALKNTA
4460 4470 4480 4490 4500
AGSLSFRAFL EDVKQNALHA FEHQDYPFEH LVEKLQVRRD LSRNPLFDTM
4510 4520 4530 4540 4550
FSLGLAESAE GEVADLKVSP YPVNGHIAKF DLSLDAMEKQ DGLLVQFSYC
4560 4570 4580 4590 4600
TKLFAKETVD RLAAHYVQLL QTITADPDIE LARISVLSKA ETEHMLHSFL
4610 4620 4630 4640 4650
ATKTAYPTDK TFQKLFEEQV EKTPNEIAVL FGNEQLTYQE LNAKANQLAR
4660 4670 4680 4690 4700
VLRRKGVKPE STVGILVDRS LYMVIGMLAV LKAGGTFVPI DPDYPLERQA
4710 4720 4730 4740 4750
FMLEDSEAKL LLTLQKMNSQ VAFPYETFYL DTETVDQEET GNLEHVAQPE
4760 4770 4780 4790 4800
NVAYIIYTSG TTGKPKGVVI EHRSYANVAF AWKDEYHLDS FPVRLLQMAS
4810 4820 4830 4840 4850
FAFDVSTGDF ARALLTGGQL VICPNGVKMD PASLYETIRR HEITIFEATP
4860 4870 4880 4890 4900
ALIMPLMHYV YENELDMSQM KLLILGADSC PAEDFKTLLA RFGQKMRIIN
4910 4920 4930 4940 4950
SYGVTEACID TSYYEETDVT AIRSGTVPIG KPLPNMTMYV VDAHLNLQPV
4960 4970 4980 4990 5000
GVVGELCIGG AGVARGYLNR PELTEEKFVP NPFAPGERLY RTGDLAKWRA
5010 5020 5030 5040 5050
DGNVEFLGRN DHQVKIRGVR IELGEIETQL RKLDGITEAV VVAREDRGQE
5060 5070 5080 5090 5100
KELCAYVVAD HKLDTAELRA NLLKELPQAM IPAYFVTLDA LPLTANGKVD
5110 5120 5130 5140 5150
RRSLPAPDVT MLRTTEYVAP RSVWEARLAQ VWEQVLNVPQ VGALDDFFAL
5160 5170 5180 5190 5200
GGHSLRAMRV LSSMHNEYQV DIPLRILFEK PTIQELAAFI EETAKGNVFS
5210 5220 5230 5240 5250
IEPVQKQAYY PVSSAQKRMY ILDQFEGVGI SYNMPSTMLI EGKLERTRVE
5260 5270 5280 5290 5300
AAFQRLIARH ESLRTSFAVV NGEPVQNIHE DVPFALAYSE VTEQEARELV
5310 5320 5330 5340 5350
SSLVQPFDLE VAPLIRVSLL KIGEDRYVLF TDMHHSISDG VSSGILLAEW
5360 5370 5380 5390 5400
VQLYQGDVLP ELRIQYKDFA VWQQEFSQSA AFHKQEAYWL QTFADDIPVL
5410 5420 5430 5440 5450
NLPTDFTRPS TQSFAGDQCT IGAGKALTEG LHQLAQATGT TLYMVLLAAY
5460 5470 5480 5490 5500
NVLLAKYAGQ EDIIVGTPIT GRSHADLEPI VGMFVNTLAM RNKPQREKTF
5510 5520 5530 5540 5550
SEFLQEVKQN ALDAYGHQDY PFEELVEKLA IARDLSRNPL FDTVFTFQNS
5560 5570 5580 5590 5600
TEEVMTLPEC TLAPFMTDET GQHAKFDLTF SATEEREEMT IGVEYSTSLF
5610 5620 5630 5640 5650
TRETMERFSR HFLTIAASIV QNPHIRLGEI DMLLPEEKQQ ILAGFNDTAV
5660 5670 5680 5690 5700
SYALDKTLHQ LFEEQVDKTP DQAALLFSEQ SLTYSELNER ANRLARVLRA
5710 5720 5730 5740 5750
KGVGPDRLVA IMAERSPEMV IGILGILKAG GAYVPVDPGY PQERIQYLLE
5760 5770 5780 5790 5800
DSNAALLLSQ AHLLPLLAQV SSELPECLDL NAELDAGLSG SNLPAVNQPT
5810 5820 5830 5840 5850
DLAYVIYTSG TTGKPKGVMI PHQGIVNCLQ WRRDEYGFGP SDKALQVFSF
5860 5870 5880 5890 5900
AFDGFVASLF APLLGGATCV LPQEAAAKDP VALKKLMAAT EVTHYYGVPS
5910 5920 5930 5940 5950
LFQAILDCST TTDFNQLRCV TLGGEKLPVQ LVQKTKEKHP AIEINNEYGP
5960 5970 5980 5990 6000
TENSVVTTIS RSIEAGQAIT IGRPLANVQV YIVDEQHHLQ PIGVVGELCI
6010 6020 6030 6040 6050
GGAGLARGYL NKPELTAEKF VANPFRPGER MYKTGDLVKW RTDGTIEYIG
6060 6070 6080 6090 6100
RADEQVKVRG YRIEIGEIES AVLAYQGIDQ AVVVARDDDA TAGSYLCAYF
6110 6120 6130 6140 6150
VAATAVSVSG LRSHLAKELP AYMIPSYFVE LDQLPLSANG KVDRKALPKP
6160 6170 6180 6190 6200
QQSDATTREY VAPRNATEQQ LAAIWQEVLG VEPIGITDQF FELGGHSLKA
6210 6220 6230 6240 6250
TLLIAKVYEY MQIELPLNLI FQYPTIEKVA DFITHKRFES RYGTAILLNQ
6260 6270 6280 6290 6300
ETARNVFCFT PIGAQSVYYQ KLAAEIQGVS LYSFDFIQDD NRMEQYIAAI
6310 6320 6330 6340 6350
TAIDPSGPYT LMGYSSGGNL AFEVAKELEE RGYGVTDIIL FDSYWKDKAI
6360 6370 6380 6390 6400
ERTVAETEND IAQLFAEIGE NTEMFNMTQE DFQLYAANEF VKQSFVRKTV
6410 6420 6430 6440 6450
SYVMFHNNLV NTGMTTAAIH LIQSELEADE EAPVAAKWNE SAWANATQRL
6460 6470 6480
LTYSGHGIHS RMLAGDYASQ NASILQNILQ ELFILK
Length:6,486
Mass (Da):724,033
Last modified:January 1, 1998 - v1
Checksum:i4934900AF07DF786
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004835 Genomic DNA. Translation: AAC45930.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004835 Genomic DNA. Translation: AAC45930.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DNYNMR-A3032-3113[»]
2GDWNMR-A3032-3113[»]
2GDXNMR-A3032-3113[»]
2GDYNMR-A3032-3113[»]
2GE1model-B3033-3113[»]
2JGPX-ray1.85A5116-5633[»]
2K2QNMR-A3033-3112[»]
2MD9NMR-A3032-3113[»]
4MRTX-ray2.00C3038-3113[»]
ProteinModelPortaliO30409.
SMRiO30409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29492N.

Protein family/group databases

ESTHERibacbr-tycc. Thioesterase.

Proteomic databases

PRIDEiO30409.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00180.
SABIO-RKO30409.

Miscellaneous databases

EvolutionaryTraceiO30409.

Family and domain databases

Gene3Di1.10.1200.10. 6 hits.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 6 hits.
PF13193. AMP-binding_C. 6 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 6 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 6 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 6 hits.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 6 hits.
PROSITEiPS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYCC_BREPA
AccessioniPrimary (citable) accession number: O30409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino acids in the growth medium.

Keywords - Technical termi

3D-structure, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.