Reviewed, UniProtKB/Swiss-Prot O30409 (TYCC_BREPA)

Names and origin

Protein names

Recommended name:
    Tyrocidine synthetase 3
Alternative name(s):
    Tyrocidine synthetase III
Including the following 6 domains:
    1- Recommended name:
            ATP-dependent asparagine adenylase
                Short name=AsnA
        Alternative name(s):
            Asparagine activase
    2- Recommended name:
            ATP-dependent glutamine adenylase
                Short name=GlnA
        Alternative name(s):
            Glutamine activase
    3- Recommended name:
            ATP-dependent tyrosine adenylase
                Short name=TyrA
        Alternative name(s):
            Tyrosine activase
    4- Recommended name:
            ATP-dependent valine adenylase
                Short name=ValA
        Alternative name(s):
            Valine activase
    5- Recommended name:
            ATP-dependent ornithine adenylase
                Short name=OrnA
        Alternative name(s):
            Ornithine activase
    6- Recommended name:
            ATP-dependent leucine adenylase
                Short name=LeuA
        Alternative name(s):
            Leucine activase

Gene names

Name:

tycC

Organism

Brevibacillus parabrevis

Taxonomic identifier

54914 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Paenibacillaceae › Brevibacillus

Protein attributes

Sequence length	6486 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product.
Cofactor	Binds 6 phosphopantetheines covalently By similarity.
Pathway	Antibiotic biosynthesis; tyrocidine biosynthesis.
Subunit structure	Large multienzyme complex of tycA, tycB and tycC.
Domain	Consists of six modules, and harbors a putative thioesterase domain at its C-terminal end. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).
Miscellaneous	Tyrocidine is a mixture of four cyclic decapeptides, tyrocidine A (D-Phe-Pro-Phe-D-Phe-Asn-Gln-Tyr-Val-Orn-Leu), B, C, and D, in which Phe, at positions 3, 4, and Tyr residues are gradually replaced by Trp, depending on the relative concentrations of these amino acids in the growth medium.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. Contains 6 acyl carrier domains.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Domain	Repeat
Ligand	Phosphopantetheine
Molecular function	Ligase
Technical term	3D-structure Multifunctional enzyme
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 6486

6486

Tyrocidine synthetase 3

PRO_0000193095

Regions

Domain

970 – 1037

68

Acyl carrier 1

Domain

2007 – 2074

68

Acyl carrier 2

Domain

3045 – 3112

68

Acyl carrier 3

Domain

4080 – 4147

68

Acyl carrier 4

Domain

5124 – 5191

68

Acyl carrier 5

Domain

6167 – 6234

68

Acyl carrier 6

Region

466 – 1038

573

Domain 1 (asparagine-activating)

Region

1521 – 2070

550

Domain 2 (glutamine-activating)

Region

2536 – 3113

578

Domain 3 (tyrosine-activating)

Region

3590 – 4149

560

Domain 4 (valine-activating)

Region

4606 – 5203

598

Domain 5 (ornithine-activating)

Region

5658 – 6245

588

Domain 6 (leucine-activating)

Amino acid modifications

Modified residue

1000

1

O-(pantetheine 4'-phosphoryl)serine By similarity

Modified residue

2037

1

O-(pantetheine 4'-phosphoryl)serine By similarity

Modified residue

3075

1

O-(pantetheine 4'-phosphoryl)serine

Modified residue

4110

1

O-(pantetheine 4'-phosphoryl)serine By similarity

Modified residue

5154

1

O-(pantetheine 4'-phosphoryl)serine By similarity

Modified residue

6197

1

O-(pantetheine 4'-phosphoryl)serine By similarity

Secondary structure

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6486

Helix Strand Turn

Details...

Helix

3044 – 3057

14

Helix

3076 – 3088

13

Helix

3095 – 3100

6

Helix

3104 – 3112

9

Helix

5123 – 5136

14

Turn

5147 – 5151

5

Helix

5154 – 5168

15

Helix

5174 – 5179

6

Helix

5183 – 5192

10

Beta strand

5208 – 5211

4

Helix

5214 – 5225

12

Turn

5229 – 5232

4

Beta strand

5236 – 5242

7

Helix

5246 – 5259

14

Helix

5261 – 5264

4

Beta strand

5265 – 5270

6

Beta strand

5273 – 5278

6

Beta strand

5287 – 5290

4

Helix

5293 – 5302

10

Beta strand

5315 – 5323

9

Beta strand

5326 – 5334

9

Helix

5335 – 5337

3

Helix

5340 – 5354

15

Helix

5366 – 5376

11

Helix

5380 – 5392

13

Beta strand

5415 – 5422

8

Helix

5425 – 5438

14

Helix

5442 – 5458

17

Beta strand

5463 – 5469

7

Helix

5475 – 5477

3

Beta strand

5486 – 5492

7

Helix

5500 – 5516

17

Helix

5522 – 5528

7

Beta strand

5542 – 5548

7

Beta strand

5558 – 5564

7

Beta strand

5575 – 5584

10

Beta strand

5589 – 5596

8

Turn

5597 – 5599

3

Helix

5602 – 5621

20

Helix

5627 – 5629

3

Sequences

	Sequence		Length	Mass (Da)
	O30409-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4934900AF07DF786	FASTA	6,486	724,033
	10 20 30 40 50 60 MKKQENIAKI YPLTPLQEGM LFHAVTDTGS SAYCLQMSAT IEGDFHLPLF EKSLNKLVEN 70 80 90 100 110 120 YEVLRTAFVY QNMQRPRQVV FKERKVTVPC ENIAHLPSAE QDAYIQAYTK QHHAFDLTKD 130 140 150 160 170 180 NLMKAAIFQT AENKYRLVWA FHHIIVDGWT LGVLLHKLLT YYAALRKGEP IPREATKPYS 190 200 210 220 230 240 EYIKWLDKQN KDEALAYWQN YLAGYDHQAA FPKKKLGTEA SRYEHVEAMF TIAPEKTQQL 250 260 270 280 290 300 IQIANQNQAT MSSVFQALWG ILASTYKNAD DVVFGSVVSG RPPQIQGIES MVGLFINTIP 310 320 330 340 350 360 TRVQTNKQQT FSELLQTVQK QALASATYDF APLYEIQSTT VLKQELIDHL VTFENYPDHS 370 380 390 400 410 420 MKHLEESLGF QFTVESGDEQ TSYDLNVVVA LAPSNELYVK LSYNAAVYES SFVNRIEGHL 430 440 450 460 470 480 RTVIDQVIGN PHVHLHEIGI ITEEEKQQLL VAYNDTAAEY PRDKTIFELI AEQASRTPAK 490 500 510 520 530 540 AAVVCGEDTL TYQELMERSA QLANALREKG IASGSIVSIM AEHSLELIVA IMAVLRSGAA 550 560 570 580 590 600 YLPIDPEYPQ DRIQYLLDDS QTTLLLTQSH LQPNIRFAGS VLYLDDRSLY EGGSTSFAPE 610 620 630 640 650 660 SKPDDLAYMI YTSGSTGNPK GAMITHQGLV NYIWWANKVY VQGEAVDFPL YSSISFDLTV 670 680 690 700 710 720 TSIFTPLLSG NTIHVYRGAD KVQVILDIIK DNKVGIIKLT PTHLKLIEHI DGKASSIRRF 730 740 750 760 770 780 IVGGENLPTK LAKQIYDHFG ENVQIFNEYG PTETVVGCMI YLYDPQTTTQ ESVPIGVPAD 790 800 810 820 830 840 NVQLYLLDAS MQPVPVGSLG EMYIAGDGVA KGYFNRPELT KEKFIDNPFR PGTKMYRTGD 850 860 870 880 890 900 LAKWLPDGNM EYAGRMDYQV KIRGHRIEMG EIETRLTQHE AVKEAVVIVE KDESGQNVLY 910 920 930 940 950 960 AYLVSERELT VAELREFLGR TLPSYMIPSF FIRLAEIPLT ANGKVERKKL PKPAGAVVTG 970 980 990 1000 1010 1020 TAYAAPQNEI EAKLAEIWQQ VLGISQVGIH DDFFDLGGHS LKAMTVVFQV SKALEVELPV 1030 1040 1050 1060 1070 1080 KALFEHPTVA ELARFLSRSE KTEYTAIQPV AAQEFYPVSS AQKRMYILQQ FEGNGISYNI 1090 1100 1110 1120 1130 1140 SGAILLEGKL DYARFASAVQ QLAERHEALR TSFHRIDGEP VQKVHEEVEV PLFMLEAPED 1150 1160 1170 1180 1190 1200 QAEKIMREFV RPFDLGVAPL MRTGLLKLGK DRHLFLLDMH HIISDGVSSQ ILLREFAELY 1210 1220 1230 1240 1250 1260 QGADLQPLSL QYKDFAAWQN ELFQTEAYKK QEQHWLNTFA DEIPLLNLPT DYPRPSVQSF 1270 1280 1290 1300 1310 1320 AGDLVLFAAG KELLERLQQV ASETGTTLYM ILLAAYNVLL SKYTGQEDII VGTPVAGRSH 1330 1340 1350 1360 1370 1380 ADVENIMGIF VNTLALRNQP ASSKTFAQFL QEVKQNALAA YDHQDYPFEE LVEKLAIQRD 1390 1400 1410 1420 1430 1440 ISRNPLFDTL FSLENANQQS LAIAELTASP YELFNKISKF DLALNASESP ADIQFQLTFA 1450 1460 1470 1480 1490 1500 TKLFKKETVE RMARHYLEIL RWISEQPTAS LADIDMMTEA EKRTLLLNVN DTFVERTAAT 1510 1520 1530 1540 1550 1560 ALHQLVEEQA ARTPDEVAVV YEEYALTYRE LNARANQLAR LLRSHGTGPD TLIGIMVDRS 1570 1580 1590 1600 1610 1620 PGMVVGMLAV LKAGGAYTPI DPSYPPERIQ YMLSDSQAPI LLTQRHLQEL AAYQGEIIDV 1630 1640 1650 1660 1670 1680 DEEAIYTGAD TNLDNVAGKD DLAYVIYTSG STGNPKGVMI SHQAICNHML WMRETFPLTT 1690 1700 1710 1720 1730 1740 EDAVLQKTPF SFDASVWEFY LPLITGGQLV LAKPDGHRDI AYMTRLIRDE KITTLQMVPS 1750 1760 1770 1780 1790 1800 LLDLVMTDPG WSACTSLQRV FCGGEALTPA LVSRFYETQQ AQLINLYGPT ETTIDATYWP 1810 1820 1830 1840 1850 1860 CPRQQEYSAI PIGKPIDNVR LYVVNASNQL QPVGVAGELC IAGDGLARGY WQREELTKAS 1870 1880 1890 1900 1910 1920 FVDNPFEPGG TMYRTGDMVR YLPDGHIEYL GRIDHQVKIR GHRIELGEIE ATLLQHEAVK 1930 1940 1950 1960 1970 1980 AVVVMARQDG KGQNSLYAYV VAEQDIQTAE LRTYLSATLP AYMVPSAFVF LEQLPLSANG 1990 2000 2010 2020 2030 2040 KVDRKALPQP EDAAASAAVY VAPRNEWEAK LAAIWESVLG VEPIGVHDHF FELGGHSLKA 2050 2060 2070 2080 2090 2100 MHVISLLQRS FQVDVPLKVL FESPTIAGLA PLVAAARKGT YTAIPPVEKQ EYYPVSAAQK 2110 2120 2130 2140 2150 2160 RMFILQQMEG AGISYNMPGF MYLDGKLDTE RLQQALKSLV QRHESLRTSF HSVQGETVQR 2170 2180 2190 2200 2210 2220 VHDDVDLAIS FGEATEAETR QIAEQFIQPF DLGTAPLLRA GLIKLAPERH LFMLDLHHIV 2230 2240 2250 2260 2270 2280 VDGVSIGLLI EEFAQLYHGE ELPALRIQYK DFAKWQQDWF QTEEFAEQEA YWLNTFTGEI 2290 2300 2310 2320 2330 2340 PVLNLPTDYP RPSVKSFAGD RFVFGSGTAL PKQLHQLAQE TGTTLYMVLL AAYNVLLSKY 2350 2360 2370 2380 2390 2400 SRQEDIIVGA PTAGRSHAET ESIVGMFVNT LALRNEPAGG KTFRDFLAEV KINTLGAFEH 2410 2420 2430 2440 2450 2460 QDYPLDELVD KLDMQRDLSR NPLFDTVFIL QNMEQKPFEM EQLTITPYSA EVKQAKFDLS 2470 2480 2490 2500 2510 2520 LEAYEENAEI IFSLDYSTKL FSRETIEKIA THFIQILRAV IAEPEMPLSE ITMLTEAEKQ 2530 2540 2550 2560 2570 2580 RLLVDFNGAH KDFPQNKTLQ ALFEEQAEKS PQATAVEISG QPLSYQELNE RANQLAATLR 2590 2600 2610 2620 2630 2640 ERGVQPDQPV GIMANRSVEM VVGILAILKA GGAYVPIDPE YPEERVAYML TDCQARLVLT 2650 2660 2670 2680 2690 2700 QKHLGAKLGS SVTAECLYLD DESNYGVHRS NLQPINTASD LAYIIYTSGT TGKPKGVMVE 2710 2720 2730 2740 2750 2760 HRGIVNNVLW KKAEYQMKVG DRSLLSLSFA FDAFVLSFFT PVLSGATVVL AEDEEAKDPV 2770 2780 2790 2800 2810 2820 SLKKLIAASR CTLMTGVPSL FQAILECSTP ADIRPLQTVT LGGEKITAQL VEKCKQLNPD 2830 2840 2850 2860 2870 2880 LVIVNEYGPT ESSVVATWQR LAGPDAAITI GRPIANTSLY IVNQYHQLQP IGVVGEICIG 2890 2900 2910 2920 2930 2940 GRGLARGYWN KPALTEEKFV SHPFAAGERM YKTGDLGKWL PDGTIEYIGR IDEQVKVRGY 2950 2960 2970 2980 2990 3000 RIEIGEIESA LLAAEKLTAA VVVVYEDQLG QSALAAYFTA DEQLDVTKLW SHLSKRLPSY 3010 3020 3030 3040 3050 3060 MIPAHFVQLD QLPLTPNGKV DKKALPKPEG KPVTEAQYVA PTNAVESKLA EIWERVLGVS 3070 3080 3090 3100 3110 3120 GIGILDNFFQ IGGHSLKAMA VAAQVHREYQ VELPLKVLFA QPTIKALAQY VATSGKETYV 3130 3140 3150 3160 3170 3180 PIEPAPLQEY YPVSSAQKRM YVLRQFADTG TVYNMPSALY IEGDLDRKRF EAAIHGLVER 3190 3200 3210 3220 3230 3240 HESLRTSFHT VNGEPVQRVH EHVELNVQYA EVTEAQVEPT VESFVQAFDL TKAPLLRVGL 3250 3260 3270 3280 3290 3300 FKLAAKRHLF LLDMHHIISD GVSAGIIMEE FSKLYRGEEL PALSVHYKDF AVWQSELFQS 3310 3320 3330 3340 3350 3360 DVYTEHENYW LNAFSGDIPV LNLPADFSRP LTQSFEGDCV SFQADKALLD DLHKLAQESQ 3370 3380 3390 3400 3410 3420 STLFMVLLAA YNVLLAKYSG QEDIVVGTPI AGRSHADIEN VLGMFVNTLA LRNYPVETKH 3430 3440 3450 3460 3470 3480 FQAFLEEVKQ NTLQAYAHQD YPFEALVEKL DIQRDLSRNP LFDTMFILQN LDQKAYELDG 3490 3500 3510 3520 3530 3540 LKLEAYPAQA GNAKFDLTLE AHEDETGIHF ALVYSTKLFQ RESIERMAGH FLQVLRQVVA 3550 3560 3570 3580 3590 3600 DQATALREIS LLSEEERRIV TVDFNNTFAA YPRDLTIQEL FEQQAAKTPE HAAVVMDGQM 3610 3620 3630 3640 3650 3660 LTYRELNEKA NQLAHVLRQN GVGKESIVGL LADRSLEMIT GIMGILKAGG AYLGLDPEHP 3670 3680 3690 3700 3710 3720 SERLAYMLED GGVKVVLVQK HLLPLVGEGL MPIVLEEESL RPEDCGNPAI VNGASDLAYV 3730 3740 3750 3760 3770 3780 MYTSGSTGKP KGVMVEHRNV TRLVMHTNYV QVRESDRMIQ TGAIGFDAMT FEIFGALLHG 3790 3800 3810 3820 3830 3840 ASLYLVSKDV LLDAEKLGDF LRTNQITTMW LTSPLFNQLS QDNPAMFDSL RALIVGGEAL 3850 3860 3870 3880 3890 3900 SPKHINRVKS ALPDLEIWNG YGPTENTTFS TCYLIEQHFE EQIPIGKPIA NSTAYIVDGN 3910 3920 3930 3940 3950 3960 NQPQPIGVPG ELCVGGDGVA RGYVNKPELT AEKFVPNPFA PGETMYRTGD LARWLPDGTI 3970 3980 3990 4000 4010 4020 EYLGRIDQQV KIRGYRIELG EIETVLSQQA QVKEAVVAVI EEANGQKALC AYFVPEQAVD 4030 4040 4050 4060 4070 4080 AAELREAMSK QLPGYMVPAY YVQMEKLPLT ANGKVDRRAL PQPSGERTTG SAFVAAQNDT 4090 4100 4110 4120 4130 4140 EAKLQQIWQE VLGIPAIGIH DNFFEIGGHS LKAMNVITQV HKTFQVELPL KALFATPTIH 4150 4160 4170 4180 4190 4200 ELAAHIAESA FEQFETIQPV EPAAFYPVSF AQKRMYILHQ FEGSGISYNV PSVLVLEGKL 4210 4220 4230 4240 4250 4260 DYDRFAAAIQ SLVKRHESLR TSFHSVNGEP LQRVHPDVEL PVRLLEATED QSESLIQELI 4270 4280 4290 4300 4310 4320 QPFDLEIAPL FRVNLIKLGA ERHLFFMDMH HIISDGVSLA VIVEEIASLY AGKQLSDLRI 4330 4340 4350 4360 4370 4380 QYKDFAVWQT KLAQSDRFQK QEDFWTRTFA GEIPLLNLPH DYPRPSVQSF DGDTVALGTG 4390 4400 4410 4420 4430 4440 HHLLEQLRKL AAETGTTLFM VLLAAYHVLL SKYAGQEEIV VGTPIAGRSH ADVERIVGMF 4450 4460 4470 4480 4490 4500 VNTLALKNTA AGSLSFRAFL EDVKQNALHA FEHQDYPFEH LVEKLQVRRD LSRNPLFDTM 4510 4520 4530 4540 4550 4560 FSLGLAESAE GEVADLKVSP YPVNGHIAKF DLSLDAMEKQ DGLLVQFSYC TKLFAKETVD 4570 4580 4590 4600 4610 4620 RLAAHYVQLL QTITADPDIE LARISVLSKA ETEHMLHSFL ATKTAYPTDK TFQKLFEEQV 4630 4640 4650 4660 4670 4680 EKTPNEIAVL FGNEQLTYQE LNAKANQLAR VLRRKGVKPE STVGILVDRS LYMVIGMLAV 4690 4700 4710 4720 4730 4740 LKAGGTFVPI DPDYPLERQA FMLEDSEAKL LLTLQKMNSQ VAFPYETFYL DTETVDQEET 4750 4760 4770 4780 4790 4800 GNLEHVAQPE NVAYIIYTSG TTGKPKGVVI EHRSYANVAF AWKDEYHLDS FPVRLLQMAS 4810 4820 4830 4840 4850 4860 FAFDVSTGDF ARALLTGGQL VICPNGVKMD PASLYETIRR HEITIFEATP ALIMPLMHYV 4870 4880 4890 4900 4910 4920 YENELDMSQM KLLILGADSC PAEDFKTLLA RFGQKMRIIN SYGVTEACID TSYYEETDVT 4930 4940 4950 4960 4970 4980 AIRSGTVPIG KPLPNMTMYV VDAHLNLQPV GVVGELCIGG AGVARGYLNR PELTEEKFVP 4990 5000 5010 5020 5030 5040 NPFAPGERLY RTGDLAKWRA DGNVEFLGRN DHQVKIRGVR IELGEIETQL RKLDGITEAV 5050 5060 5070 5080 5090 5100 VVAREDRGQE KELCAYVVAD HKLDTAELRA NLLKELPQAM IPAYFVTLDA LPLTANGKVD 5110 5120 5130 5140 5150 5160 RRSLPAPDVT MLRTTEYVAP RSVWEARLAQ VWEQVLNVPQ VGALDDFFAL GGHSLRAMRV 5170 5180 5190 5200 5210 5220 LSSMHNEYQV DIPLRILFEK PTIQELAAFI EETAKGNVFS IEPVQKQAYY PVSSAQKRMY 5230 5240 5250 5260 5270 5280 ILDQFEGVGI SYNMPSTMLI EGKLERTRVE AAFQRLIARH ESLRTSFAVV NGEPVQNIHE 5290 5300 5310 5320 5330 5340 DVPFALAYSE VTEQEARELV SSLVQPFDLE VAPLIRVSLL KIGEDRYVLF TDMHHSISDG 5350 5360 5370 5380 5390 5400 VSSGILLAEW VQLYQGDVLP ELRIQYKDFA VWQQEFSQSA AFHKQEAYWL QTFADDIPVL 5410 5420 5430 5440 5450 5460 NLPTDFTRPS TQSFAGDQCT IGAGKALTEG LHQLAQATGT TLYMVLLAAY NVLLAKYAGQ 5470 5480 5490 5500 5510 5520 EDIIVGTPIT GRSHADLEPI VGMFVNTLAM RNKPQREKTF SEFLQEVKQN ALDAYGHQDY 5530 5540 5550 5560 5570 5580 PFEELVEKLA IARDLSRNPL FDTVFTFQNS TEEVMTLPEC TLAPFMTDET GQHAKFDLTF 5590 5600 5610 5620 5630 5640 SATEEREEMT IGVEYSTSLF TRETMERFSR HFLTIAASIV QNPHIRLGEI DMLLPEEKQQ 5650 5660 5670 5680 5690 5700 ILAGFNDTAV SYALDKTLHQ LFEEQVDKTP DQAALLFSEQ SLTYSELNER ANRLARVLRA 5710 5720 5730 5740 5750 5760 KGVGPDRLVA IMAERSPEMV IGILGILKAG GAYVPVDPGY PQERIQYLLE DSNAALLLSQ 5770 5780 5790 5800 5810 5820 AHLLPLLAQV SSELPECLDL NAELDAGLSG SNLPAVNQPT DLAYVIYTSG TTGKPKGVMI 5830 5840 5850 5860 5870 5880 PHQGIVNCLQ WRRDEYGFGP SDKALQVFSF AFDGFVASLF APLLGGATCV LPQEAAAKDP 5890 5900 5910 5920 5930 5940 VALKKLMAAT EVTHYYGVPS LFQAILDCST TTDFNQLRCV TLGGEKLPVQ LVQKTKEKHP 5950 5960 5970 5980 5990 6000 AIEINNEYGP TENSVVTTIS RSIEAGQAIT IGRPLANVQV YIVDEQHHLQ PIGVVGELCI 6010 6020 6030 6040 6050 6060 GGAGLARGYL NKPELTAEKF VANPFRPGER MYKTGDLVKW RTDGTIEYIG RADEQVKVRG 6070 6080 6090 6100 6110 6120 YRIEIGEIES AVLAYQGIDQ AVVVARDDDA TAGSYLCAYF VAATAVSVSG LRSHLAKELP 6130 6140 6150 6160 6170 6180 AYMIPSYFVE LDQLPLSANG KVDRKALPKP QQSDATTREY VAPRNATEQQ LAAIWQEVLG 6190 6200 6210 6220 6230 6240 VEPIGITDQF FELGGHSLKA TLLIAKVYEY MQIELPLNLI FQYPTIEKVA DFITHKRFES 6250 6260 6270 6280 6290 6300 RYGTAILLNQ ETARNVFCFT PIGAQSVYYQ KLAAEIQGVS LYSFDFIQDD NRMEQYIAAI 6310 6320 6330 6340 6350 6360 TAIDPSGPYT LMGYSSGGNL AFEVAKELEE RGYGVTDIIL FDSYWKDKAI ERTVAETEND 6370 6380 6390 6400 6410 6420 IAQLFAEIGE NTEMFNMTQE DFQLYAANEF VKQSFVRKTV SYVMFHNNLV NTGMTTAAIH 6430 6440 6450 6460 6470 6480 LIQSELEADE EAPVAAKWNE SAWANATQRL LTYSGHGIHS RMLAGDYASQ NASILQNILQ ELFILK

References

[1]	"The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains." Mootz H.D., Marahiel M.A. J. Bacteriol. 179:6843-6850(1997) [PubMed: 9352938] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 8185 / IAM 1031 / IFO 3331 / NCDO 717 / NCIB 8598.
[2]	"Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases." Weber T., Baumgartner R., Renner C., Marahiel M.A., Holak T.A. Structure 8:407-418(2000) [PubMed: 10801488] [Abstract] Cited for: STRUCTURE BY NMR OF 3032-3113.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF004835 Genomic DNA. Translation: AAC45930.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DNY	NMR	-	A	3032-3113	[»]
2GDW	NMR	-	A	3033-3113	[»]
2GDX	NMR	-	A	3033-3113	[»]
2GDY	NMR	-	A	3033-3113	[»]
2GE1	model	-	B	3033-3113	[»]
2JGP	X-ray	1.85	A	5116-5633	[»]
2K2Q	NMR	-	A	3033-3112	[»]

ModBase

Search...

Family and domain databases

InterPro

IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR006163. Phsphopanteth_bd.
IPR006162. Ppantne_S.
IPR001031. Thioesterase.
[Graphical view]

Pfam

PF00501. AMP-binding. 6 hits.
PF00668. Condensation. 6 hits.
PF00550. PP-binding. 6 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01733. AA-adenyl-dom. 6 hits.

PROSITE

PS50075. ACP_DOMAIN. 6 hits.
PS00455. AMP_BINDING. 6 hits.
PS00012. PHOSPHOPANTETHEINE. 6 hits.
[Graphical view]

ProtoNet

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Entry information

Entry name

TYCC_BREPA

Accession

Primary (citable) accession number: O30409

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)