O30405 (GLPQ_TREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerophosphoryl diester phosphodiesterase
Short name=Glycerophosphodiester phosphodiesterase
EC=3.1.4.46

Gene names

Name:	glpQ
Synonyms:	glp
Ordered Locus Names:	TP_0257

Organism

Treponema pallidum (strain Nichols) [Complete proteome] [HAMAP]

Taxonomic identifier

243276 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Treponema

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols By similarity.
Catalytic activity	A glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.
Subcellular location	Cell outer membrane; Lipid-anchor.
Sequence similarities	Belongs to the glycerophosphoryl diester phosphodiesterase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal
Molecular function	Hydrolase
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycerophosphodiester phosphodiesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 356	336	Glycerophosphoryl diester phosphodiesterase		PRO_0000012596
Amino acid modifications
	Lipidation	21	1	N-palmitoyl cysteine By similarity
	Lipidation	21	1	S-diacylglycerol cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O30405 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7AD414E70A4C799A	FASTA	356	41,014
	10 20 30 40 50 60 MRGTYCVTLW GGVFAALVAG CASERMIVAY RGAAGYVPEH TFASKVLAFA QGADYLQQDV 70 80 90 100 110 120 VLSKDNQLIV AQSHILDNMT DVAEKFPRRQ RADGHFYVID FTVEELSLLR ATNSFYTRGK 130 140 150 160 170 180 RHTPVYGQRF PLWKPGFRLH TFEEELQFIR GLEQTTGKKI GIYSEIKVPW FHHQEGKDIA 190 200 210 220 230 240 ALTLALLKKY GYQSRSDLVY VQTYDFNELK RIKRELLPKY EMNVKLIQRV AYTDQRETQE 250 260 270 280 290 300 KDSRGKWINY NYNWMFEPGG MQKIAKYADG VGPDWRMLIE NEWSKVGAVR LSPMVSAIQD 310 320 330 340 350 AKLECHVHTV RKETLPSYAR TMDEMFSILF KQTGANVVLT DFPDLGVKFL GKPARY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase homologue." Stebeck C.E., Shaffer J.M., Arroll T.W., Lukehart S.A., van Voorhis W.C. FEMS Microbiol. Lett. 154:303-310(1997) [PubMed: 9311129] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Nichols.
[2]	"Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete." Shevchenko D.V., Akins D.R., Robinson E.J., Li M., Shevchenko O.V., Radolf J.D. Infect. Immun. 65:4179-4189(1997) [PubMed: 9317025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete genome sequence of Treponema pallidum, the syphilis spirochete." Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K. , Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C. Science 281:375-388(1998) [PubMed: 9665876] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nichols.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF004286 Genomic DNA. Translation: AAB81591.1. U95744 Genomic DNA. Translation: AAC08323.1. AE000520 Genomic DNA. Translation: AAC65246.1.
PIR	F71346.
RefSeq	NP_218698.1. NC_000919.1.
3D structure databases
ProteinModelPortal	O30405.
SMR	O30405. Positions 24-350.
ModBase	Search...
Protein-protein interaction databases
IntAct	O30405. 3 interactions.
MINT	MINT-6481004.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2611763.
GenomeReviews	Gene locus TP_0257 in contig AE000520_GR.
KEGG	tpa:TP0257.
PATRIC	20530503. VBITrePal57110_0277.
TIGR	TP_0257.
Phylogenomic databases
HOGENOM	HBG725117.
OMA	YSYDWMF.
ProtClustDB	PRK11143.
Enzyme and pathway databases
BioCyc	TPAL243276:TP_0257-MONOMER.
Family and domain databases
InterPro	IPR004129. GlyceroP-diester-Pdiesterase. IPR017946. PLC-like_Pdiesterase_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
KO	K01126.
PANTHER	PTHR23344. GDPD. 1 hit.
Pfam	PF03009. GDPD. 1 hit. [Graphical view]
SUPFAM	SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS51257. PROKAR_LIPOPROTEIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPQ_TREPA

Accession

Primary (citable) accession number: O30405

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program