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O30298 (SUHB_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Inositol-1-monophosphatase
Short name=I-1-Pase
Short name=IMPase
Short name=Inositol-1-phosphatase
EC=3.1.3.25
Gene names
Name:suhB
Ordered Locus Names:AF_2372
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Myo-inositol phosphate + H2O = myo-inositol + phosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the inositol monophosphatase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Inositol-1-monophosphatase
PRO_0000142579

Sites

Metal binding671Magnesium 1
Metal binding821Magnesium 1
Metal binding821Magnesium 2
Metal binding841Magnesium 1; via carbonyl oxygen
Metal binding851Magnesium 2
Metal binding2001Magnesium 2
Binding site851Substrate
Binding site1551Substrate
Binding site1671Substrate
Binding site1911Substrate

Secondary structure

1 ................................................ 252
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O30298 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: EF48983721AEA687

FASTA25227,967
        10         20         30         40         50         60 
MDERDALRIS REIAGEVRKA IASMPLRERV KDVGMGKDGT PTKAADRVAE DAALEILRKE 

        70         80         90        100        110        120 
RVTVVTEESG VLGEGDVFVA LDPLDGTFNA TRGIPVYSVS LCFSYSDKLK DAFFGYVYNL 

       130        140        150        160        170        180 
ATGDEYYADS SGAYRNGERI EVSDAEELYC NAIIYYPDRK FPFKRMRIFG SAATELCFFA 

       190        200        210        220        230        240 
DGSFDCFLDI RPGKMLRIYD AAAGVFIAEK AGGKVTELDG ESLGNKKFDM QERLNIVAAN 

       250 
EKLHPKLLEL IK

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. expand/collapse author list , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
Nature 390:364-370(1997) [PubMed: 9389475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]"Overexpression, purification, and analysis of complementation behavior of E. coli SuhB protein: comparison with bacterial and archaeal inositol monophosphatases."
Chen L., Roberts M.F.
Biochemistry 39:4145-4153(2000) [PubMed: 10747806] [Abstract]
Cited for: CHARACTERIZATION.
[3]"Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop."
Stieglitz K.A., Johnson K.A., Yang H., Roberts M.F., Seaton B.A., Head J.F., Stec B.
J. Biol. Chem. 277:22863-22874(2002) [PubMed: 11940584] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) IN COMPLEX WITH SUBSTRATE AND METAL IONS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB91288.1.
PIRD69546.
RefSeqNP_071195.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LBVX-ray1.80A/B1-252[»]
1LBWX-ray2.00A/B1-252[»]
1LBXX-ray2.40A/B1-252[»]
1LBYX-ray2.25A/B1-252[»]
1LBZX-ray2.20A/B1-252[»]
ProteinModelPortalO30298.
SMRO30298. Positions 1-252.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1485602.
GenomeReviewsGene locus AF_2372 in contig AE000782_GR.
KEGGafu:AF2372.
NMPDRfig|224325.1.peg.2356.
TIGRAF_2372.

Phylogenomic databases

HOGENOMHBG730251.
OMAYSVSLCF.
ProtClustDBCLSK2747293.

Enzyme and pathway databases

BioCycAFUL224325:AF_2372-MONOMER.
BRENDA3.1.3.25. 414.

Family and domain databases

InterProIPR000760. Inositol_monophosphatase.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
KOK01092.
PANTHERPTHR20854. Inositol_P. 1 hit.
PfamPF00459. Inositol_P. 1 hit.
[Graphical view]
PRINTSPR00377. IMPHPHTASES.
PROSITEPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUHB_ARCFU
AccessionPrimary (citable) accession number: O30298
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 1, 1998
Last modified: November 16, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents