Acetyl-CoA decarbonylase/synthase complex subunit alpha 2

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Reviewed, UniProtKB/Swiss-Prot O30274 (ACDA2_ARCFU)

Last modified June 16, 2009. Version 61. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Acetyl-CoA decarbonylase/synthase complex subunit alpha 2
      Short name=ACDS complex subunit alpha 2
    EC=1.2.99.2
Alternative name(s):
    ACDS complex carbon monoxide dehydrogenase 2
      Short name=ACDS CODH 2

Gene names

Name:	cdhA2
Ordered Locus Names:	AF_2397

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

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Protein attributes

Sequence length	798 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO₂ By similarity.
Catalytic activity	CO + H₂O + A = CO₂ + AH₂. HAMAP MF_01137
Cofactor	Binds 7 4Fe-4S clusters per heterotetramer Potential. Binds 2 nickel-iron-sulfur clusters per heterotetramer Potential.
Subunit structure	Heterotetramer of two alpha and two epsilon chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha₂epsilon₂)(4)-beta(8)-(gamma₁delta₁)₈ Potential.
Domain	Cluster B is an all-cysteinyl-liganded 4Fe4S cluster; cluster C is a mixed Ni-Fe-S cluster which appears to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe4S cluster that bridges the two subunits of the CODH dimer. May contain two additional 4Fe-4S clusters, dubbed E and F, that might reroute electron transfer along different paths. HAMAP MF_01137
Sequence similarities	Belongs to the Ni-containing carbon monoxide dehydrogenase family. Contains 2 4Fe-4S ferredoxin-type domains.

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Ontologies

Keywords
Domain	Repeat
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding Nickel
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro generation of precursor metabolites and energy Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW carbon-monoxide dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nickel ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 798

798

Acetyl-CoA decarbonylase/synthase complex subunit alpha 2 HAMAP MF_01137

PRO_0000155073

Regions

Domain

395 – 424

4Fe-4S ferredoxin-type 1

Domain

434 – 463

4Fe-4S ferredoxin-type 2

Sites

Metal binding

Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity

Metal binding

Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

246

Nickel-iron-sulfur By similarity

Metal binding

274

Nickel-iron-sulfur By similarity

Metal binding

313

Nickel-iron-sulfur By similarity

Metal binding

405

Iron-sulfur 3 (4Fe-4S) Potential

Metal binding

408

Iron-sulfur 3 (4Fe-4S) Potential

Metal binding

411

Iron-sulfur 3 (4Fe-4S) Potential

Metal binding

415

Iron-sulfur 3 (4Fe-4S) Potential

Metal binding

443

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

446

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

449

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

453

Iron-sulfur 4 (4Fe-4S) Potential

Metal binding

511

Nickel-iron-sulfur By similarity

Metal binding

540

Nickel-iron-sulfur By similarity

Metal binding

575

Nickel-iron-sulfur By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

O30274-1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: FC3CBCCB41BD30A0
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FASTA

798

88,378

        10         20         30         40         50         60 
MVLEFGKGAF VVDDLRNVTI KIGEIAEEEE EWAPMGPTPM PGIATLRDWD FFLLKRYKPF 

        70         80         90        100        110        120 
YAPACDMCCL CTMGKCDLTG NKRGACGIDL AAQTGRIVTI ACSIGVSAHT GHARHMLHDI 

       130        140        150        160        170        180 
EHMTGKKLSE IPVDLGPEID EVAPLTELIT GIKPKTLEDL ERALRYAEEQ IVQVVDAVHT 

       190        200        210        220        230        240 
GQEGSYLDYE SKALHLGMLD SLGKEIADIA QICAFGYPKG EDNQPLIEVG MGVMDRSKAM 

       250        260        270        280        290        300 
ILVIGHHAPP VLNIADYIEE NGLEDEVDLG GICCTANDMT RYYQKAKIVS ALGRQLKVIR 

       310        320        330        340        350        360 
AGLADVIVID EQCIRADILY HTKKLGIPVI CTNEKAMHAL PDMTKEEPKN IIKYLLDGNP 

       370        380        390        400        410        420 
GCVILDPLKV GEVAVEVARA RRKQRGDDIG PRLTEEQFME YARACTQCGN CTIACPQGIR 

       430        440        450        460        470        480 
IGEAMEAAEN GDRSKLEKEW DVCIACGRCE QVCPKGIPII DMYNYAAWNL IVNEKGKLRR 

       490        500        510        520        530        540 
GRGPIRDSEI RNVGAPIVLG TIPGIIAVIG CGNYPNGTRD AYTIMDEFAS RNYIVVTTGC 

       550        560        570        580        590        600 
MAFDAALYKD EEGQTVYEKY HDRFDGGGVV QIGSCVANAH IHGAAIKVAR IFAKRNIRAN 

       610        620        630        640        650        660 
YEEIADYILN RVGACGVAWG AYSQKAASIA TGFNRLGIPA VVGPHGSKYR RAFLGRPYND 

       670        680        690        700        710        720 
EDWMVYDART GEKVRIEPAP QDLLVAAETI EEAIPLMAKL CFRPNDTTQG RSIKLTHYID 

       730        740        750        760        770        780 
LSLKYLKRMP DDWHLFVRTE ADLPLAKKEE LLKELEDKHG WKIDWQKKKI VEGPIRGYHA 

       790 
GFNPTNLERC LRDGFMTV

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References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.

Venter J.C.
Nature 390:364-370(1997) [PubMed: 9389475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

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Cross-references

Sequence databases
	AE000782 Genomic DNA. Translation: AAB91266.1.
PIR	F69549.
RefSeq	NP_071219.1.
3D structure databases
HSSP	HSSP built from PDB template 1FCA based on UniProtKB P00198.
ModBase	Search...
Genome annotation databases
GeneID	1485627.
GenomeReviews	Gene locus AF_2397 in contig AE000782_GR.
KEGG	afu:AF2397.
NMPDR	fig\|224325.1.peg.2381.
TIGR	AF_2397.
Phylogenomic databases
HOGENOM	O30274.
OMA	O30274. ICCTAID.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_2397-MON.
BRENDA	1.2.99.2. 7576.
Family and domain databases
HAMAP	MF_01137. [Tree]
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR001450. 4Fe4S_Fe_S_bd_subgr. IPR017900. 4Fe4S_Fe_S_CS. IPR004460. CO_DH/Ac-CoA_synth_asu. IPR016101. CO_DH_a-bundle. IPR004137. Prismane. IPR016099. Prismane-like_a/b-sand. [Graphical view]
Gene3D	G3DSA:1.20.1270.30. CO_DH_a-bundle. 1 hit. G3DSA:3.40.50.2030. Prismane-like_a/b-sand. 2 hits.
Pfam	PF00037. Fer4. 2 hits. PF03063. Prismane. 1 hit. [Graphical view]
TIGRFAMs	TIGR00314. cdhA. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 2 hits. PS51379. 4FE4S_FER_2. 2 hits. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

ACDA2_ARCFU

Accession

Primary (citable) accession number: O30274

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents