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Protein

Molybdate/tungstate import ATP-binding protein WtpC

Gene

wtpC

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system (Probable).Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 388ATPCurated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Molybdenum, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-96-MONOMER.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate import ATP-binding protein WtpC (EC:3.6.3.-)
Gene namesi
Name:wtpC
Synonyms:modC
Ordered Locus Names:AF_0092
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Molybdate/tungstate import ATP-binding protein WtpCPRO_0000338501Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).1 Publication

Protein-protein interaction databases

DIPiDIP-60272N.
STRINGi224325.AF0092.

Structurei

Secondary structure

1
240
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 119Combined sources
Beta strandi14 – 229Combined sources
Beta strandi24 – 307Combined sources
Helixi37 – 459Combined sources
Beta strandi51 – 577Combined sources
Turni67 – 693Combined sources
Helixi87 – 926Combined sources
Helixi100 – 11213Combined sources
Turni113 – 1153Combined sources
Turni117 – 1215Combined sources
Helixi124 – 1263Combined sources
Helixi129 – 14113Combined sources
Beta strandi146 – 1527Combined sources
Helixi159 – 17618Combined sources
Beta strandi180 – 1856Combined sources
Helixi187 – 1937Combined sources
Beta strandi195 – 2017Combined sources
Beta strandi204 – 2096Combined sources
Helixi211 – 2166Combined sources
Helixi222 – 2254Combined sources
Helixi226 – 2283Combined sources
Helixi229 – 23810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10A/B/F/G1-240[»]
ProteinModelPortaliO30144.
SMRiO30144. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30144.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 227226ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiarCOG00180. Archaea.
COG3839. LUCA.
KOiK15497.
OMAiNERQRAK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030283. WtpC.
[Graphical view]
PANTHERiPTHR24220:SF421. PTHR24220:SF421. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O30144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLKVRAEKR LGNFRLNVDF EMGRDYCVLL GPTGAGKSVF LELIAGIVKP
60 70 80 90 100
DRGEVRLNGA DITPLPPERR GIGFVPQDYA LFPHLSVYRN IAYGLRNVER
110 120 130 140 150
VERDRRVREM AEKLGIAHLL DRKPARLSGG ERQRVALARA LVIQPRLLLL
160 170 180 190 200
DEPLSAVDLK TKGVLMEELR FVQREFDVPI LHVTHDLIEA AMLADEVAVM
210 220 230 240
LNGRIVEKGK LKELFSAKNG EVAEFLSARN LLLKVSKILD
Length:240
Mass (Da):27,027
Last modified:January 1, 1998 - v1
Checksum:i7F81725C51B69379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91137.1.
PIRiD69261.
RefSeqiWP_010877606.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB91137; AAB91137; AF_0092.
GeneIDi1483304.
KEGGiafu:AF_0092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91137.1.
PIRiD69261.
RefSeqiWP_010877606.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10A/B/F/G1-240[»]
ProteinModelPortaliO30144.
SMRiO30144. Positions 1-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60272N.
STRINGi224325.AF0092.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91137; AAB91137; AF_0092.
GeneIDi1483304.
KEGGiafu:AF_0092.

Phylogenomic databases

eggNOGiarCOG00180. Archaea.
COG3839. LUCA.
KOiK15497.
OMAiNERQRAK.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-96-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO30144.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR030283. WtpC.
[Graphical view]
PANTHERiPTHR24220:SF421. PTHR24220:SF421. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
  2. "Structure of an ABC transporter in complex with its binding protein."
    Hollenstein K., Frei D.C., Locher K.P.
    Nature 446:213-216(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF COMPLEX WITH PHOSPHATE; WTPA AND WTPB, SUBUNIT.

Entry informationi

Entry nameiWTPC_ARCFU
AccessioniPrimary (citable) accession number: O30144
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: January 20, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.