O30144 (WTPC_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Molybdate/tungstate import ATP-binding protein WtpC
EC=3.6.3.-

Gene names

Name:	wtpC
Synonyms:	modC
Ordered Locus Names:	AF_0092

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system Probable.
Subunit structure	The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA). Ref.2
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Ligand	ATP-binding Molybdenum Nucleotide-binding
Molecular function	Hydrolase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 240

240

Molybdate/tungstate import ATP-binding protein WtpC

PRO_0000338501

Regions

Domain

2 – 227

226

ABC transporter

Nucleotide binding

31 – 38

8

ATP Probable

Secondary structure

1

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240

Helix Strand Turn

Details...

Beta strand

3 – 11

9

Beta strand

14 – 22

9

Beta strand

24 – 30

7

Helix

37 – 45

9

Beta strand

51 – 57

7

Turn

67 – 69

3

Helix

87 – 92

6

Helix

100 – 112

13

Turn

113 – 115

3

Turn

117 – 121

5

Helix

124 – 126

3

Helix

129 – 141

13

Beta strand

146 – 152

7

Helix

159 – 176

18

Beta strand

180 – 185

6

Helix

187 – 193

7

Beta strand

195 – 201

7

Beta strand

204 – 209

6

Helix

211 – 216

6

Helix

222 – 225

4

Helix

226 – 228

3

Helix

229 – 238

10

Sequences

	Sequence		Length	Mass (Da)
	O30144 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7F81725C51B69379	FASTA	240	27,027
	10 20 30 40 50 60 MFLKVRAEKR LGNFRLNVDF EMGRDYCVLL GPTGAGKSVF LELIAGIVKP DRGEVRLNGA 70 80 90 100 110 120 DITPLPPERR GIGFVPQDYA LFPHLSVYRN IAYGLRNVER VERDRRVREM AEKLGIAHLL 130 140 150 160 170 180 DRKPARLSGG ERQRVALARA LVIQPRLLLL DEPLSAVDLK TKGVLMEELR FVQREFDVPI 190 200 210 220 230 240 LHVTHDLIEA AMLADEVAVM LNGRIVEKGK LKELFSAKNG EVAEFLSARN LLLKVSKILD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]	"Structure of an ABC transporter in complex with its binding protein." Hollenstein K., Frei D.C., Locher K.P. Nature 446:213-216(2007) [PubMed: 17322901] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF COMPLEX WITH PHOSPHATE; WTPA AND WTPB, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE000782 Genomic DNA. Translation: AAB91137.1.

PIR

D69261.

RefSeq

NP_068933.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ONK	X-ray	3.10	A/B/F/G	1-240	[»]

ProteinModelPortal

O30144.

SMR

O30144. Positions 1-240.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1483304.

GenomeReviews

Gene locus AF_0092 in contig AE000782_GR.

KEGG

afu:AF0092.

TIGR

AF_0092.

Phylogenomic databases

eggNOG

COG3839.

KO

K15497.

OMA

NDNEYLI.

Enzyme and pathway databases

BioCyc

AFUL224325:AF_0092-MONOMER.

Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
[Graphical view]

Pfam

PF00005. ABC_tran. 1 hit.
[Graphical view]

SMART

SM00382. AAA. 1 hit.
[Graphical view]

PROSITE

PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O30144.

Entry information

Entry name

WTPC_ARCFU

Accession

Primary (citable) accession number: O30144

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	January 1, 1998
Last modified:	May 16, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program