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Protein

Molybdate/tungstate transport system permease protein WtpB

Gene

wtpB

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane (Probable).Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Molybdenum

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate transport system permease protein WtpB
Gene namesi
Name:wtpB
Synonyms:modB
Ordered Locus Names:AF_0093
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2Cytoplasmic1 Publication2
Transmembranei3 – 28Helical; Name=1Add BLAST26
Topological domaini29 – 46Extracellular1 PublicationAdd BLAST18
Transmembranei47 – 76Helical; Name=2Add BLAST30
Topological domaini77 – 85Cytoplasmic1 Publication9
Transmembranei86 – 110Helical; Name=3Add BLAST25
Topological domaini111 – 123Extracellular1 PublicationAdd BLAST13
Transmembranei124 – 154Helical; Name=4Add BLAST31
Topological domaini155 – 184Cytoplasmic1 PublicationAdd BLAST30
Transmembranei185 – 209Helical; Name=5Add BLAST25
Topological domaini210 – 230Extracellular1 PublicationAdd BLAST21
Transmembranei231 – 251Helical; Name=6Add BLAST21
Topological domaini252 – 261Cytoplasmic1 Publication10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003384961 – 261Molybdate/tungstate transport system permease protein WtpBAdd BLAST261

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).1 Publication

Protein-protein interaction databases

DIPiDIP-60273N.
STRINGi224325.AF0093.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 29Combined sources28
Turni30 – 34Combined sources5
Helixi35 – 43Combined sources9
Helixi45 – 77Combined sources33
Helixi84 – 96Combined sources13
Helixi99 – 110Combined sources12
Turni115 – 119Combined sources5
Helixi128 – 153Combined sources26
Helixi156 – 164Combined sources9
Helixi169 – 175Combined sources7
Helixi177 – 198Combined sources22
Helixi201 – 204Combined sources4
Helixi213 – 224Combined sources12
Helixi226 – 228Combined sources3
Helixi230 – 249Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10C/D/H/I1-261[»]
ProteinModelPortaliO30143.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30143.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 247ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 107Gate 1Add BLAST15
Regioni193 – 203Gate 2Add BLAST11

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00164. Archaea.
COG0555. LUCA.
KOiK15496.
OMAiVDNFWGI.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O30143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLFSALLA LLSSIILLFV LLPVAATVTL QLFNFDEFLK AASDPAVWKV
60 70 80 90 100
VLTTYYAALI STLIAVIFGT PLAYILARKS FPGKSVVEGI VDLPVVIPHT
110 120 130 140 150
VAGIALLVVF GSSGLIGSFS PLKFVDALPG IVVAMLFVSV PIYINQAKEG
160 170 180 190 200
FASVDVRLEH VARTLGSSPL RVFFTVSLPL SVRHIVAGAI MSWARGISEF
210 220 230 240 250
GAVVVIAYYP MIAPTLIYER YLSEGLSAAM PVAAILILLS LAVFVALRII
260
VGREDVSEGQ G
Length:261
Mass (Da):27,833
Last modified:January 1, 1998 - v1
Checksum:iC11342F58293B77F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91136.1.
PIRiE69261.
RefSeqiWP_010877607.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB91136; AAB91136; AF_0093.
GeneIDi24793648.
KEGGiafu:AF_0093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91136.1.
PIRiE69261.
RefSeqiWP_010877607.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10C/D/H/I1-261[»]
ProteinModelPortaliO30143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60273N.
STRINGi224325.AF0093.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91136; AAB91136; AF_0093.
GeneIDi24793648.
KEGGiafu:AF_0093.

Phylogenomic databases

eggNOGiarCOG00164. Archaea.
COG0555. LUCA.
KOiK15496.
OMAiVDNFWGI.

Miscellaneous databases

EvolutionaryTraceiO30143.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR000515. MetI-like.
[Graphical view]
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWTPB_ARCFU
AccessioniPrimary (citable) accession number: O30143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.