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Protein

Molybdate/tungstate-binding protein WtpA

Gene

wtpA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Molybdate or tungstate; via amide nitrogen1
Metal bindingi42Molybdate or tungstate1
Metal bindingi70Molybdate or tungstate1
Metal bindingi153Molybdate or tungstate1
Metal bindingi155Molybdate or tungstate; via amide nitrogen1
Metal bindingi218Molybdate or tungstate1
Metal bindingi236Molybdate or tungstate1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Molybdenum

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate-binding protein WtpA
Gene namesi
Name:wtpA
Synonyms:modA
Ordered Locus Names:AF_0094
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000015971725 – 342Molybdate/tungstate-binding protein WtpAAdd BLAST318

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).1 Publication

Protein-protein interaction databases

DIPiDIP-60274N.
STRINGi224325.AF0094.

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 40Combined sources7
Helixi41 – 43Combined sources3
Helixi44 – 57Combined sources14
Beta strandi62 – 68Combined sources7
Helixi70 – 78Combined sources9
Beta strandi85 – 91Combined sources7
Helixi93 – 99Combined sources7
Turni100 – 103Combined sources4
Beta strandi108 – 112Combined sources5
Beta strandi115 – 119Combined sources5
Turni124 – 128Combined sources5
Turni131 – 133Combined sources3
Helixi134 – 138Combined sources5
Beta strandi145 – 148Combined sources4
Turni150 – 152Combined sources3
Helixi154 – 169Combined sources16
Helixi175 – 179Combined sources5
Helixi181 – 183Combined sources3
Beta strandi188 – 191Combined sources4
Beta strandi194 – 198Combined sources5
Helixi202 – 204Combined sources3
Turni209 – 211Combined sources3
Beta strandi212 – 217Combined sources6
Helixi219 – 226Combined sources8
Beta strandi231 – 236Combined sources6
Helixi237 – 242Combined sources6
Beta strandi246 – 249Combined sources4
Turni252 – 254Combined sources3
Helixi259 – 261Combined sources3
Helixi262 – 265Combined sources4
Beta strandi268 – 271Combined sources4
Turni273 – 275Combined sources3
Beta strandi277 – 279Combined sources3
Beta strandi284 – 288Combined sources5
Helixi296 – 307Combined sources12
Helixi309 – 317Combined sources9
Beta strandi322 – 330Combined sources9
Helixi333 – 335Combined sources3
Turni336 – 338Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10E/J32-342[»]
2ONRX-ray1.60A32-342[»]
2ONSX-ray1.55A32-342[»]
3CIJX-ray1.07A/B32-323[»]
ProteinModelPortaliO30142.
SMRiO30142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30142.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
KOiK15495.
OMAiSPNDDPC.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O30142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIGGGVVKI RILILLMLAL FLLGCSSNVN TNVKLKVFHA GSLTEPMKAF
60 70 80 90 100
KRAFEEKHPN VEVQTEAAGS AATIRKVTEL GRKADVIATA DYTLIQKMMY
110 120 130 140 150
PEFANWTIMF AKNQIVLAYR NDSRYADEIN SQNWYEILKR PDVRFGFSNP
160 170 180 190 200
NDDPCGYRSL MAIQLAELYY NDPTIFDELV AKNSNLRFSE DNGSYVLRMP
210 220 230 240 250
SSERIEINKS KIMIRSMEME LIHLVESGEL DYFFIYKSVA KQHGFNFVEL
260 270 280 290 300
PVEIDLSSPD YAELYSKVKV VLANGKEVTG KPIVYGITIP KNAENRELAV
310 320 330 340
EFVKLVISEE GQEILRELGQ EPLVPPRADT AVPSLKAMVE VS
Length:342
Mass (Da):38,630
Last modified:January 1, 1998 - v1
Checksum:i2DACAF169A074406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91135.1.
PIRiF69261.
RefSeqiWP_010877608.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB91135; AAB91135; AF_0094.
GeneIDi1483306.
KEGGiafu:AF_0094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91135.1.
PIRiF69261.
RefSeqiWP_010877608.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10E/J32-342[»]
2ONRX-ray1.60A32-342[»]
2ONSX-ray1.55A32-342[»]
3CIJX-ray1.07A/B32-323[»]
ProteinModelPortaliO30142.
SMRiO30142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60274N.
STRINGi224325.AF0094.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91135; AAB91135; AF_0094.
GeneIDi1483306.
KEGGiafu:AF_0094.

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
KOiK15495.
OMAiSPNDDPC.

Miscellaneous databases

EvolutionaryTraceiO30142.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWTPA_ARCFU
AccessioniPrimary (citable) accession number: O30142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.