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Protein

Molybdate/tungstate-binding protein WtpA

Gene

wtpA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi41 – 411Molybdate or tungstate; via amide nitrogen
Metal bindingi42 – 421Molybdate or tungstate
Metal bindingi70 – 701Molybdate or tungstate
Metal bindingi153 – 1531Molybdate or tungstate
Metal bindingi155 – 1551Molybdate or tungstate; via amide nitrogen
Metal bindingi218 – 2181Molybdate or tungstate
Metal bindingi236 – 2361Molybdate or tungstate

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-98-MONOMER.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate/tungstate-binding protein WtpA
Gene namesi
Name:wtpA
Synonyms:modA
Ordered Locus Names:AF_0094
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 342318Molybdate/tungstate-binding protein WtpAPRO_0000159717Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (WtpC), two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).1 Publication

Protein-protein interaction databases

DIPiDIP-60274N.
STRINGi224325.AF0094.

Structurei

Secondary structure

1
342
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 407Combined sources
Helixi41 – 433Combined sources
Helixi44 – 5714Combined sources
Beta strandi62 – 687Combined sources
Helixi70 – 789Combined sources
Beta strandi85 – 917Combined sources
Helixi93 – 997Combined sources
Turni100 – 1034Combined sources
Beta strandi108 – 1125Combined sources
Beta strandi115 – 1195Combined sources
Turni124 – 1285Combined sources
Turni131 – 1333Combined sources
Helixi134 – 1385Combined sources
Beta strandi145 – 1484Combined sources
Turni150 – 1523Combined sources
Helixi154 – 16916Combined sources
Helixi175 – 1795Combined sources
Helixi181 – 1833Combined sources
Beta strandi188 – 1914Combined sources
Beta strandi194 – 1985Combined sources
Helixi202 – 2043Combined sources
Turni209 – 2113Combined sources
Beta strandi212 – 2176Combined sources
Helixi219 – 2268Combined sources
Beta strandi231 – 2366Combined sources
Helixi237 – 2426Combined sources
Beta strandi246 – 2494Combined sources
Turni252 – 2543Combined sources
Helixi259 – 2613Combined sources
Helixi262 – 2654Combined sources
Beta strandi268 – 2714Combined sources
Turni273 – 2753Combined sources
Beta strandi277 – 2793Combined sources
Beta strandi284 – 2885Combined sources
Helixi296 – 30712Combined sources
Helixi309 – 3179Combined sources
Beta strandi322 – 3309Combined sources
Helixi333 – 3353Combined sources
Turni336 – 3383Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10E/J32-342[»]
2ONRX-ray1.60A32-342[»]
2ONSX-ray1.55A32-342[»]
3CIJX-ray1.07A/B32-323[»]
ProteinModelPortaliO30142.
SMRiO30142. Positions 32-342.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO30142.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
KOiK15495.
OMAiSPNDDPC.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O30142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIGGGVVKI RILILLMLAL FLLGCSSNVN TNVKLKVFHA GSLTEPMKAF
60 70 80 90 100
KRAFEEKHPN VEVQTEAAGS AATIRKVTEL GRKADVIATA DYTLIQKMMY
110 120 130 140 150
PEFANWTIMF AKNQIVLAYR NDSRYADEIN SQNWYEILKR PDVRFGFSNP
160 170 180 190 200
NDDPCGYRSL MAIQLAELYY NDPTIFDELV AKNSNLRFSE DNGSYVLRMP
210 220 230 240 250
SSERIEINKS KIMIRSMEME LIHLVESGEL DYFFIYKSVA KQHGFNFVEL
260 270 280 290 300
PVEIDLSSPD YAELYSKVKV VLANGKEVTG KPIVYGITIP KNAENRELAV
310 320 330 340
EFVKLVISEE GQEILRELGQ EPLVPPRADT AVPSLKAMVE VS
Length:342
Mass (Da):38,630
Last modified:January 1, 1998 - v1
Checksum:i2DACAF169A074406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91135.1.
PIRiF69261.
RefSeqiWP_010877608.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB91135; AAB91135; AF_0094.
GeneIDi1483306.
KEGGiafu:AF_0094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91135.1.
PIRiF69261.
RefSeqiWP_010877608.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ONKX-ray3.10E/J32-342[»]
2ONRX-ray1.60A32-342[»]
2ONSX-ray1.55A32-342[»]
3CIJX-ray1.07A/B32-323[»]
ProteinModelPortaliO30142.
SMRiO30142. Positions 32-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60274N.
STRINGi224325.AF0094.

Protein family/group databases

TCDBi3.A.1.6.8. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB91135; AAB91135; AF_0094.
GeneIDi1483306.
KEGGiafu:AF_0094.

Phylogenomic databases

eggNOGiarCOG00219. Archaea.
COG0725. LUCA.
KOiK15495.
OMAiSPNDDPC.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-98-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO30142.

Family and domain databases

InterProiIPR022498. ABC_trnspt_W-bd_WtpA.
[Graphical view]
TIGRFAMsiTIGR03730. tungstate_WtpA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWTPA_ARCFU
AccessioniPrimary (citable) accession number: O30142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.