O30129 (PYRI_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase regulatory chain

Gene names

Name:	pyrI
Ordered Locus Names:	AF_0107

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in allosteric regulation of aspartate carbamoyltransferase By similarity. HAMAP MF_00002
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00002
Subunit structure	Contains catalytic and regulatory chains.
Sequence similarities	Belongs to the pyrI family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	aspartate carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	Aspartate carbamoyltransferase regulatory chain HAMAP MF_00002		PRO_0000142327
Sites
	Metal binding	107	1	Zinc By similarity
	Metal binding	112	1	Zinc By similarity
	Metal binding	138	1	Zinc By similarity
	Metal binding	141	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	O30129 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 0E677FD0ABC09FF6	FASTA	153	17,255
	10 20 30 40 50 60 MRELVVSKIK EGTVIDHINA GKALLVLKIL KIQPGTDLTV SMAMNVPSSK MGKKDIVKVE 70 80 90 100 110 120 GMFIRDEELN KIALISPNAT INLIRDYEIE RKFKVSPPEV VEGVLKCPNH ACISNAEREP 130 140 150 ITPKFYIKTE EMRATARCHY CGRKIENLDN YIS

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB91124.1.
PIR	C69263.
RefSeq	NP_068948.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O30129.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483319.
GenomeReviews	Gene locus AF_0107 in contig AE000782_GR.
KEGG	afu:AF0107.
NMPDR	fig|224325.1.peg.107.
TIGR	AF_0107.
Phylogenomic databases
HOGENOM	HBG305327.
OMA	TVIDHIT.
PhylomeDB	O30129.
ProtClustDB	PRK00893.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0107-MONOMER.
Family and domain databases
HAMAP	MF_00002. Asp_carb_tr_reg. [Tree]
InterPro	IPR020545. Asp_carbamoyltransf_reg_N. IPR002801. Asp_carbamoylTrfase_reg. IPR020542. Asp_carbamoyltrfase_reg_C. [Graphical view]
Gene3D	G3DSA:2.30.30.20. PyrI. 1 hit. G3DSA:3.30.70.140. PyrI. 1 hit.
KO	K00610.
Pfam	PF01948. PyrI. 1 hit. PF02748. PyrI_C. 1 hit. [Graphical view]
ProDom	PD006194. Asp_carbamoylTrfase_reg. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF54893. Asp_carbamoylTrfase_reg. 1 hit. SSF57825. Asp_transf_reg_C. 1 hit.
TIGRFAMs	TIGR00240. ATCase_reg. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PYRI_ARCFU

Accession

Primary (citable) accession number: O30129

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program