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Protein

Putative uroporphyrinogen-III synthase

Gene

AF_0116

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Delta-aminolevulinic acid dehydratase (hemB)
  2. Probable porphobilinogen deaminase (hemC)
  3. Putative uroporphyrinogen-III synthase (AF_0116)
  4. no protein annotated in this organism
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Ordered Locus Names:AF_0116
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352481 – 226Putative uroporphyrinogen-III synthaseAdd BLAST226

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0116.

Structurei

3D structure databases

ProteinModelPortaliO30120.
SMRiO30120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG02048. Archaea.
COG1587. LUCA.
KOiK01719.
OrthoDBiPOG093Z0AQY.

Family and domain databases

CDDicd06578. HemD. 1 hit.
InterProiView protein in InterPro
IPR036108. 4pyrrol_syn_uPrphyn_synt_sf.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
PfamiView protein in Pfam
PF02602. HEM4. 1 hit.
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

O30120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLILRPAE LLSETIRRFR EEGFDAYGCP FIKLIYTDFD VPEHDFAIVT
60 70 80 90 100
SQNAARVLRE RGVRLKRVIA IGKKTAELIE AEEVLLPSKF DSETLYEEFA
110 120 130 140 150
EMLRGKRVVA FRSNAGSEAV KRLSEVADFR EIQVYRIEKL QGEEQRREVE
160 170 180 190 200
KVREGFYDAI VFSSSMIARS LLELCDEKCL EALKNIFVVA IGPPTAKVLA
210 220
EKGIRAEIPE EYTFDGVIEL LKSKKM
Length:226
Mass (Da):25,856
Last modified:January 1, 1998 - v1
Checksum:i8BB11FDA86D3D1AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB91112.1.
PIRiD69264.
RefSeqiWP_010877630.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB91112; AAB91112; AF_0116.
GeneIDi24793670.
KEGGiafu:AF_0116.

Similar proteinsi

Entry informationi

Entry nameiHEM4_ARCFU
AccessioniPrimary (citable) accession number: O30120
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families