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O30120 (HEM4_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Ordered Locus Names:AF_0116
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Putative uroporphyrinogen-III synthase
PRO_0000135248

Sequences

Sequence LengthMass (Da)Tools
O30120 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 8BB11FDA86D3D1AD

FASTA22625,856
        10         20         30         40         50         60 
MKVLILRPAE LLSETIRRFR EEGFDAYGCP FIKLIYTDFD VPEHDFAIVT SQNAARVLRE 

        70         80         90        100        110        120 
RGVRLKRVIA IGKKTAELIE AEEVLLPSKF DSETLYEEFA EMLRGKRVVA FRSNAGSEAV 

       130        140        150        160        170        180 
KRLSEVADFR EIQVYRIEKL QGEEQRREVE KVREGFYDAI VFSSSMIARS LLELCDEKCL 

       190        200        210        220 
EALKNIFVVA IGPPTAKVLA EKGIRAEIPE EYTFDGVIEL LKSKKM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB91112.1.
PIRD69264.
RefSeqNP_068957.1. NC_000917.1.

3D structure databases

ProteinModelPortalO30120.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF0116.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB91112; AAB91112; AF_0116.
GeneID1483328.
KEGGafu:AF0116.

Phylogenomic databases

eggNOGCOG1587.
KOK01719.
ProtClustDBCLSK2746312.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-120-MONOMER.
UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_ARCFU
AccessionPrimary (citable) accession number: O30120
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways