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O30027

- HISX_ARCFU

UniProt

O30027 - HISX_ARCFU

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei114 – 1141NADBy similarity
    Binding sitei176 – 1761NADBy similarity
    Binding sitei199 – 1991NADBy similarity
    Binding sitei222 – 2221SubstrateBy similarity
    Metal bindingi244 – 2441ZincBy similarity
    Binding sitei244 – 2441SubstrateBy similarity
    Metal bindingi247 – 2471ZincBy similarity
    Binding sitei247 – 2471SubstrateBy similarity
    Active sitei300 – 3001Proton acceptorBy similarity
    Active sitei301 – 3011Proton acceptorBy similarity
    Binding sitei301 – 3011SubstrateBy similarity
    Metal bindingi334 – 3341ZincBy similarity
    Binding sitei334 – 3341SubstrateBy similarity
    Binding sitei388 – 3881SubstrateBy similarity
    Metal bindingi393 – 3931ZincBy similarity
    Binding sitei393 – 3931SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciAFUL224325:GJBC-216-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:AF_0212
    OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
    Taxonomic identifieri224325 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000002199: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Histidinol dehydrogenasePRO_0000135890Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224325.AF0212.

    Structurei

    3D structure databases

    ProteinModelPortaliO30027.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiYAAKLCG.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O30027-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEILRLRRS VSIDDYIEKV KPIVEAVKRE GDKAVIRFTR DLDGVELDSL    50
    RVTEDEFEKA YDAVDDGLID ALEVAKENIY RFHYVTSVER DMKVEFEDCV 100
    MGKIYTPIEK VGAYIPGGRA SYPSTALMIG VPAKIAGVEK LVACTPPNKD 150
    GKVNPLTLVA LDIAEFDEVY KAGGAQAIAA MAYGTETVEK VYKIVGPGNI 200
    YVTAAKLLVA KDVAIDMPAG PSEILVIADE TANADFIACD CLAQLEHDPM 250
    AVAVVLTTSR KVADEVEKKV KSEGDFSNFA VFVVEDLAEA FEISNEFAPE 300
    HLTVAVKNPE EWLGKVRNAG SVFLGNFSPV AAGDYASGTN HVLPTAGYAK 350
    IYGGLSVESF LKHFTFQMLS EESMRRIGGD VVKIAEAEGL RWHAESVRKR 400
    LEKI 404
    Length:404
    Mass (Da):44,152
    Last modified:January 1, 1998 - v1
    Checksum:i344264D010F20966
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB91021.1.
    PIRiD69276.
    RefSeqiNP_069050.1. NC_000917.1.
    WP_010877723.1. NC_000917.1.

    Genome annotation databases

    EnsemblBacteriaiAAB91021; AAB91021; AF_0212.
    GeneIDi1483423.
    KEGGiafu:AF0212.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB91021.1 .
    PIRi D69276.
    RefSeqi NP_069050.1. NC_000917.1.
    WP_010877723.1. NC_000917.1.

    3D structure databases

    ProteinModelPortali O30027.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224325.AF0212.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB91021 ; AAB91021 ; AF_0212 .
    GeneIDi 1483423.
    KEGGi afu:AF0212.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi YAAKLCG.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci AFUL224325:GJBC-216-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
      Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
      , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
      Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

    Entry informationi

    Entry nameiHISX_ARCFU
    AccessioniPrimary (citable) accession number: O30027
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3