O30027 (HISX_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol dehydrogenase
Short name=HDH
EC=1.1.1.23

Gene names

Name:	hisD
Ordered Locus Names:	AF_0212

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01024
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Histidinol dehydrogenase HAMAP MF_01024		PRO_0000135890
Sites
	Active site	300	1	Proton acceptor By similarity
	Active site	301	1	Proton acceptor By similarity
	Metal binding	244	1	Zinc By similarity
	Metal binding	247	1	Zinc By similarity
	Metal binding	334	1	Zinc By similarity
	Metal binding	393	1	Zinc By similarity
	Binding site	114	1	NAD By similarity
	Binding site	176	1	NAD By similarity
	Binding site	199	1	NAD By similarity
	Binding site	222	1	Substrate By similarity
	Binding site	244	1	Substrate By similarity
	Binding site	247	1	Substrate By similarity
	Binding site	301	1	Substrate By similarity
	Binding site	334	1	Substrate By similarity
	Binding site	388	1	Substrate By similarity
	Binding site	393	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O30027 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 344264D010F20966	FASTA	404	44,152
	10 20 30 40 50 60 MEEILRLRRS VSIDDYIEKV KPIVEAVKRE GDKAVIRFTR DLDGVELDSL RVTEDEFEKA 70 80 90 100 110 120 YDAVDDGLID ALEVAKENIY RFHYVTSVER DMKVEFEDCV MGKIYTPIEK VGAYIPGGRA 130 140 150 160 170 180 SYPSTALMIG VPAKIAGVEK LVACTPPNKD GKVNPLTLVA LDIAEFDEVY KAGGAQAIAA 190 200 210 220 230 240 MAYGTETVEK VYKIVGPGNI YVTAAKLLVA KDVAIDMPAG PSEILVIADE TANADFIACD 250 260 270 280 290 300 CLAQLEHDPM AVAVVLTTSR KVADEVEKKV KSEGDFSNFA VFVVEDLAEA FEISNEFAPE 310 320 330 340 350 360 HLTVAVKNPE EWLGKVRNAG SVFLGNFSPV AAGDYASGTN HVLPTAGYAK IYGGLSVESF 370 380 390 400 LKHFTFQMLS EESMRRIGGD VVKIAEAEGL RWHAESVRKR LEKI

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB91021.1.
PIR	D69276.
RefSeq	NP_069050.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O30027.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483423.
GenomeReviews	Gene locus AF_0212 in contig AE000782_GR.
KEGG	afu:AF0212.
NMPDR	fig|224325.1.peg.209.
TIGR	AF_0212.
Phylogenomic databases
HOGENOM	HBG329596.
OMA	IMTKNPR.
PhylomeDB	O30027.
ProtClustDB	CLSK2746336.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0212-MONOMER.
Family and domain databases
HAMAP	MF_01024. HisD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR001692. Histidinol_DH_CS. IPR022695. Histidinol_DH_monofunct. IPR012131. Hstdl_DH. [Graphical view]
KO	K00013.
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000099. Histidinol_dh. 1 hit.
PRINTS	PR00083. HOLDHDRGNASE.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00069. HisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX_ARCFU

Accession

Primary (citable) accession number: O30027

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program