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O30027 (HISX_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:AF_0212
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135890

Sites

Active site3001Proton acceptor By similarity
Active site3011Proton acceptor By similarity
Metal binding2441Zinc By similarity
Metal binding2471Zinc By similarity
Metal binding3341Zinc By similarity
Metal binding3931Zinc By similarity
Binding site1141NAD By similarity
Binding site1761NAD By similarity
Binding site1991NAD By similarity
Binding site2221Substrate By similarity
Binding site2441Substrate By similarity
Binding site2471Substrate By similarity
Binding site3011Substrate By similarity
Binding site3341Substrate By similarity
Binding site3881Substrate By similarity
Binding site3931Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O30027 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 344264D010F20966

FASTA40444,152
        10         20         30         40         50         60 
MEEILRLRRS VSIDDYIEKV KPIVEAVKRE GDKAVIRFTR DLDGVELDSL RVTEDEFEKA 

        70         80         90        100        110        120 
YDAVDDGLID ALEVAKENIY RFHYVTSVER DMKVEFEDCV MGKIYTPIEK VGAYIPGGRA 

       130        140        150        160        170        180 
SYPSTALMIG VPAKIAGVEK LVACTPPNKD GKVNPLTLVA LDIAEFDEVY KAGGAQAIAA 

       190        200        210        220        230        240 
MAYGTETVEK VYKIVGPGNI YVTAAKLLVA KDVAIDMPAG PSEILVIADE TANADFIACD 

       250        260        270        280        290        300 
CLAQLEHDPM AVAVVLTTSR KVADEVEKKV KSEGDFSNFA VFVVEDLAEA FEISNEFAPE 

       310        320        330        340        350        360 
HLTVAVKNPE EWLGKVRNAG SVFLGNFSPV AAGDYASGTN HVLPTAGYAK IYGGLSVESF 

       370        380        390        400 
LKHFTFQMLS EESMRRIGGD VVKIAEAEGL RWHAESVRKR LEKI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB91021.1.
PIRD69276.
RefSeqNP_069050.1. NC_000917.1.

3D structure databases

ProteinModelPortalO30027.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF0212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB91021; AAB91021; AF_0212.
GeneID1483423.
KEGGafu:AF0212.

Phylogenomic databases

eggNOGCOG0141.
KOK00013.
OMAPSEILII.
ProtClustDBCLSK2746336.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-216-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_ARCFU
AccessionPrimary (citable) accession number: O30027
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways