O29999 (ADEC_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	AF_0240

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Adenine deaminase HAMAP MF_01518		PRO_0000142438

Sequences

	Sequence		Length	Mass (Da)
	O29999 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B3E3440A09F86A79	FASTA	556	60,764
	10 20 30 40 50 60 MSSPTADVEK LRRIIEVARG DRRADFVVKN AQIVDLVNEE IFEGDIAVAE GFIAGIGSYS 70 80 90 100 110 120 GVEECEASNL VAVPGLIDAH THIEMSMLTV SEFARLVVPR GTTGVVADPH EIANVLGKDG 130 140 150 160 170 180 VMLMLEEARS TPLRFYCMVP SCVPSSPLET SGARIGVEEI RELLEEEEVL GLAEMMNFPG 190 200 210 220 230 240 VVSADREVLE KIVLAGIVDG HAPGLRGKKL NAYIAAGASS DHETTSFEEG KEKLRLGMWV 250 260 270 280 290 300 MIREGSAARN LVALKGLTGN RHTMLVTDGD RSVKDIIEEG YLDHVFRRAI EEGIDEIKAL 310 320 330 340 350 360 QMLTLNPAEY FGINAGLIAP SRLADIVLLK NLRKFEVRDV FVGGRRPEFK RFNHPEWAKK 370 380 390 400 410 420 TVKARKITPE SIQLKTGRVR VIEVYDGEIV TGEAIEEVQG VDVERDILKA VVVERHIRSG 430 440 450 460 470 480 RVGKAYVRGF GLKRGAIAQS IAHDAHNIVC VGVDDGSICA AVNRVIELQG GIVVADAEVR 490 500 510 520 530 540 AELPLPIAGI MSDERAERVL ERLSEIEEEV RKLGCRLKSP VITLSFIALP VIPKLKLTDL 550 GLVDVEAFRV VDLQAD

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90993.1.
PIR	H69279.
RefSeq	NP_069078.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29999.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483451.
GenomeReviews	Gene locus AF_0240 in contig AE000782_GR.
KEGG	afu:AF0240.
NMPDR	fig|224325.1.peg.237.
TIGR	AF_0240.
Phylogenomic databases
HOGENOM	HBG725357.
OMA	VGLGEMM.
PhylomeDB	O29999.
ProtClustDB	CLSK2746354.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0240-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_ARCFU

Accession

Primary (citable) accession number: O29999

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program