Skip Header

Contribute Send feedback
Read comments (?) or add your own

O29986 (GUAAB_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing] subunit B

EC=6.3.5.2
Alternative name(s):
GMP synthetase
Gene names
Name:guaAB
Synonyms:guaA-1
Ordered Locus Names:AF_0253
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of GMP from XMP By similarity. HAMAP MF_00345

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. HAMAP MF_00345

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1. HAMAP MF_00345

Subunit structure

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B) Potential.

Sequence similarities

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GMP synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303GMP synthase [glutamine-hydrolyzing] subunit B HAMAP MF_00345
PRO_0000140237

Regions

Domain1 – 183183GMPS ATP-PPase
Nucleotide binding28 – 347ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
O29986 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: FC6259333E624BC2

FASTA30334,119
        10         20         30         40         50         60 
MDVEKFVENA IKEIRERVKD GKAIIALSGG VDSSVCTVLA HKALGDRLIP VFVDTGLMRE 

        70         80         90        100        110        120 
GEPEKIKEIF GNMGLVFIDA KEEFFKALKG VTDPEEKRKV IGELFVRIFE RVAEEHNAEY 

       130        140        150        160        170        180 
LIQGTIYPDI IESQGGIKSH HNVGGFPTSY KFKDVIEPLR ELYKDEVREV ARYLGLPKEI 

       190        200        210        220        230        240 
SERMPFPGPG LAVRIVGEVT PEKVEIVRKA NKIVEEELAD YDKWQCFAAL IGKATGVKGD 

       250        260        270        280        290        300 
VRVWGYIIAV RAVESRDGMT ADPIKIDYDR LRRIALRITG EIDKVSRVVY DITPKPPATI 


EYE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90977.1.
PIRE69281.
RefSeqNP_069091.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29986.
SMRO29986. Positions 1-303.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1483464.
GenomeReviewsGene locus AF_0253 in contig AE000782_GR.
KEGGafu:AF0253.
NMPDRfig|224325.1.peg.250.
TIGRAF_0253.

Phylogenomic databases

HOGENOMHBG391775.
OMAQGTIAPD.
ProtClustDBPRK00919.

Enzyme and pathway databases

BioCycAFUL224325:AF_0253-MONOMER.

Family and domain databases

HAMAPMF_00345. GMP_synthase_B.
[Tree]
InterProIPR001674. GMP_synth_C.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
PROSITEPS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAAB_ARCFU
AccessionPrimary (citable) accession number: O29986
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families