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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi3.1.26.4. 414.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:AF_0335
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491921 – 245DNA polymerase sliding clampAdd BLAST245

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF0335.

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi8 – 19Combined sources12
Beta strandi23 – 30Combined sources8
Beta strandi33 – 39Combined sources7
Beta strandi43 – 52Combined sources10
Helixi53 – 55Combined sources3
Beta strandi56 – 63Combined sources8
Beta strandi65 – 70Combined sources6
Helixi71 – 78Combined sources8
Beta strandi85 – 101Combined sources17
Beta strandi104 – 109Combined sources6
Helixi113 – 115Combined sources3
Beta strandi128 – 134Combined sources7
Helixi135 – 146Combined sources12
Beta strandi150 – 157Combined sources8
Beta strandi160 – 166Combined sources7
Beta strandi171 – 176Combined sources6
Helixi178 – 180Combined sources3
Beta strandi181 – 184Combined sources4
Beta strandi189 – 194Combined sources6
Helixi195 – 201Combined sources7
Helixi202 – 204Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi217 – 219Combined sources3
Beta strandi221 – 227Combined sources7
Turni228 – 231Combined sources4
Beta strandi232 – 238Combined sources7
Beta strandi241 – 243Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RWZX-ray1.80A1-245[»]
1RXMX-ray2.80A1-245[»]
1RXZX-ray2.00A1-245[»]
3P83X-ray3.05A/B/C1-245[»]
ProteinModelPortaliO29912.
SMRiO29912.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29912.

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
KOiK04802.
OMAiTIYLGNN.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O29912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDVIMTGEL LKTVTRAIVA LVSEARIHFL EKGLHSRAVD PANVAMVIVD
60 70 80 90 100
IPKDSFEVYN IDEEKTIGVD MDRIFDISKS ISTKDLVELI VEDESTLKVK
110 120 130 140 150
FGSVEYKVAL IDPSAIRKEP RIPELELPAK IVMDAGEFKK AIAAADKISD
160 170 180 190 200
QVIFRSDKEG FRIEAKGDVD SIVFHMTETE LIEFNGGEAR SMFSVDYLKE
210 220 230 240
FCKVAGSGDL LTIHLGTNYP VRLVFELVGG RAKVEYILAP RIESE
Length:245
Mass (Da):27,267
Last modified:January 1, 1998 - v1
Checksum:i5665CDA0EA393CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90899.1.
PIRiG69291.
RefSeqiWP_010877842.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90899; AAB90899; AF_0335.
GeneIDi24793874.
KEGGiafu:AF_0335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90899.1.
PIRiG69291.
RefSeqiWP_010877842.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RWZX-ray1.80A1-245[»]
1RXMX-ray2.80A1-245[»]
1RXZX-ray2.00A1-245[»]
3P83X-ray3.05A/B/C1-245[»]
ProteinModelPortaliO29912.
SMRiO29912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90899; AAB90899; AF_0335.
GeneIDi24793874.
KEGGiafu:AF_0335.

Phylogenomic databases

eggNOGiarCOG00488. Archaea.
COG0592. LUCA.
KOiK04802.
OMAiTIYLGNN.

Enzyme and pathway databases

BRENDAi3.1.26.4. 414.

Miscellaneous databases

EvolutionaryTraceiO29912.

Family and domain databases

HAMAPiMF_00317. DNApol_clamp_arch. 1 hit.
InterProiIPR000730. Pr_cel_nuc_antig.
IPR022649. Pr_cel_nuc_antig_C.
IPR022659. Pr_cel_nuc_antig_CS.
IPR022648. Pr_cel_nuc_antig_N.
[Graphical view]
PANTHERiPTHR11352. PTHR11352. 1 hit.
PfamiPF02747. PCNA_C. 1 hit.
PF00705. PCNA_N. 1 hit.
[Graphical view]
PRINTSiPR00339. PCNACYCLIN.
PROSITEiPS01251. PCNA_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCNA_ARCFU
AccessioniPrimary (citable) accession number: O29912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.