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Protein

Putative methylthioribose-1-phosphate isomerase

Gene

AF_0370

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86SubstrateUniRule annotation1
Sitei152Transition state stabilizerUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Active sitei232Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
MTNA-like proteinUniRule annotation
Short name:
aMTNAUniRule annotation
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Ordered Locus Names:AF_0370
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560851 – 339Putative methylthioribose-1-phosphate isomeraseAdd BLAST339

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0370.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Helixi15 – 17Combined sources3
Turni18 – 20Combined sources3
Beta strandi24 – 27Combined sources4
Helixi30 – 38Combined sources9
Helixi45 – 59Combined sources15
Helixi68 – 83Combined sources16
Helixi90 – 103Combined sources14
Helixi109 – 139Combined sources31
Beta strandi147 – 150Combined sources4
Beta strandi155 – 162Combined sources8
Helixi165 – 174Combined sources10
Beta strandi180 – 184Combined sources5
Turni187 – 190Combined sources4
Helixi191 – 194Combined sources4
Helixi196 – 202Combined sources7
Beta strandi206 – 210Combined sources5
Helixi212 – 214Combined sources3
Helixi215 – 220Combined sources6
Beta strandi225 – 229Combined sources5
Beta strandi232 – 235Combined sources4
Beta strandi238 – 242Combined sources5
Helixi245 – 254Combined sources10
Beta strandi259 – 262Combined sources4
Helixi265 – 267Combined sources3
Helixi274 – 276Combined sources3
Helixi285 – 288Combined sources4
Beta strandi305 – 311Combined sources7
Helixi312 – 314Combined sources3
Beta strandi316 – 320Combined sources5
Beta strandi323 – 325Combined sources3
Helixi329 – 336Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5OX-ray1.90A/B/C/D2-339[»]
ProteinModelPortaliO29877.
SMRiO29877.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29877.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 45Substrate bindingUniRule annotation3
Regioni241 – 242Substrate bindingUniRule annotation2

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
KOiK08963.
OMAiFYNPAFD.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

O29877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIFWDDGL KLIDQTKLPE KLEVIECRNV EELADAIKKL AVRGAPALEA
60 70 80 90 100
AGAYGIALAA REREFADVDE LKEHLKKAAD FLASTRPTAV NLFVGIERAL
110 120 130 140 150
NAALKGESVE EVKELALREA EKLAEEDVER NRKMGEYGAE LLEDGDVVLT
160 170 180 190 200
YCNAGRLATV DWGTALGVVR SAVEQGKEIR VIACETRPLN QGSRLTCWEL
210 220 230 240 250
MEDGIDVTLI TDSMVGIVMQ KGMVDKVIVG ADRIVRDAVF NKIGTYTVSV
260 270 280 290 300
VAKHHNIPFY VAAPKATFDW ERTAKDVVIE ERPREELIFC GKRQIAPLNV
310 320 330
KVYNPAFDPT PLENVTALIT EYGVIYPPYE VNVPKVLKF
Length:339
Mass (Da):37,631
Last modified:January 1, 1998 - v1
Checksum:i79BC6636690F763F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90865.1.
PIRiB69296.
RefSeqiWP_010877877.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90865; AAB90865; AF_0370.
GeneIDi24793909.
KEGGiafu:AF_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90865.1.
PIRiB69296.
RefSeqiWP_010877877.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T5OX-ray1.90A/B/C/D2-339[»]
ProteinModelPortaliO29877.
SMRiO29877.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0370.

Protocols and materials databases

DNASUi1483585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90865; AAB90865; AF_0370.
GeneIDi24793909.
KEGGiafu:AF_0370.

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
KOiK08963.
OMAiFYNPAFD.

Miscellaneous databases

EvolutionaryTraceiO29877.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_ARCFU
AccessioniPrimary (citable) accession number: O29877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.