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Protein

Putative methylthioribose-1-phosphate isomerase

Gene

AF_0370

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).UniRule annotation

Catalytic activityi

S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861SubstrateUniRule annotation
Sitei152 – 1521Transition state stabilizerUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Active sitei232 – 2321Proton donorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-380-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative methylthioribose-1-phosphate isomeraseUniRule annotation (EC:5.3.1.23UniRule annotation)
Short name:
M1PiUniRule annotation
Short name:
MTR-1-P isomeraseUniRule annotation
Alternative name(s):
MTNA-like proteinUniRule annotation
Short name:
aMTNAUniRule annotation
S-methyl-5-thioribose-1-phosphate isomeraseUniRule annotation
Gene namesi
Ordered Locus Names:AF_0370
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Putative methylthioribose-1-phosphate isomerasePRO_0000156085Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0370.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1311Combined sources
Helixi15 – 173Combined sources
Turni18 – 203Combined sources
Beta strandi24 – 274Combined sources
Helixi30 – 389Combined sources
Helixi45 – 5915Combined sources
Helixi68 – 8316Combined sources
Helixi90 – 10314Combined sources
Helixi109 – 13931Combined sources
Beta strandi147 – 1504Combined sources
Beta strandi155 – 1628Combined sources
Helixi165 – 17410Combined sources
Beta strandi180 – 1845Combined sources
Turni187 – 1904Combined sources
Helixi191 – 1944Combined sources
Helixi196 – 2027Combined sources
Beta strandi206 – 2105Combined sources
Helixi212 – 2143Combined sources
Helixi215 – 2206Combined sources
Beta strandi225 – 2295Combined sources
Beta strandi232 – 2354Combined sources
Beta strandi238 – 2425Combined sources
Helixi245 – 25410Combined sources
Beta strandi259 – 2624Combined sources
Helixi265 – 2673Combined sources
Helixi274 – 2763Combined sources
Helixi285 – 2884Combined sources
Beta strandi305 – 3117Combined sources
Helixi312 – 3143Combined sources
Beta strandi316 – 3205Combined sources
Beta strandi323 – 3253Combined sources
Helixi329 – 3368Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5OX-ray1.90A/B/C/D2-339[»]
ProteinModelPortaliO29877.
SMRiO29877. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29877.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni43 – 453Substrate bindingUniRule annotation
Regioni241 – 2422Substrate bindingUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
KOiK08963.
OMAiFYNPAFD.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.

Sequencei

Sequence statusi: Complete.

O29877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIFWDDGL KLIDQTKLPE KLEVIECRNV EELADAIKKL AVRGAPALEA
60 70 80 90 100
AGAYGIALAA REREFADVDE LKEHLKKAAD FLASTRPTAV NLFVGIERAL
110 120 130 140 150
NAALKGESVE EVKELALREA EKLAEEDVER NRKMGEYGAE LLEDGDVVLT
160 170 180 190 200
YCNAGRLATV DWGTALGVVR SAVEQGKEIR VIACETRPLN QGSRLTCWEL
210 220 230 240 250
MEDGIDVTLI TDSMVGIVMQ KGMVDKVIVG ADRIVRDAVF NKIGTYTVSV
260 270 280 290 300
VAKHHNIPFY VAAPKATFDW ERTAKDVVIE ERPREELIFC GKRQIAPLNV
310 320 330
KVYNPAFDPT PLENVTALIT EYGVIYPPYE VNVPKVLKF
Length:339
Mass (Da):37,631
Last modified:January 1, 1998 - v1
Checksum:i79BC6636690F763F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90865.1.
PIRiB69296.
RefSeqiWP_010877877.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90865; AAB90865; AF_0370.
GeneIDi24793909.
KEGGiafu:AF_0370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90865.1.
PIRiB69296.
RefSeqiWP_010877877.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T5OX-ray1.90A/B/C/D2-339[»]
ProteinModelPortaliO29877.
SMRiO29877. Positions 1-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0370.

Protocols and materials databases

DNASUi1483585.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90865; AAB90865; AF_0370.
GeneIDi24793909.
KEGGiafu:AF_0370.

Phylogenomic databases

eggNOGiarCOG01123. Archaea.
COG0182. LUCA.
KOiK08963.
OMAiFYNPAFD.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-380-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO29877.

Family and domain databases

Gene3Di1.20.120.420. 1 hit.
HAMAPiMF_01678. Salvage_MtnA. 1 hit.
InterProiIPR000649. IF-2B-related.
IPR005251. IF-M1Pi.
IPR011559. Initiation_fac_2B_a/b/d.
IPR027363. M1Pi_N.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00524. eIF-2B_rel. 1 hit.
TIGR00512. salvage_mtnA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTNA_ARCFU
AccessioniPrimary (citable) accession number: O29877
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.