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O29876

- OGG1_ARCFU

UniProt

O29876 - OGG1_ARCFU

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Protein

Probable N-glycosylase/DNA lyase

Gene
ogg, AF_0371
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei122 – 1221 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-381-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:AF_0371
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Probable N-glycosylase/DNA lyaseUniRule annotationPRO_0000159563Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0371.

Structurei

3D structure databases

ProteinModelPortaliO29876.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
KOiK03653.
OMAiSEACFCI.

Family and domain databases

Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

O29876-1 [UniParc]FASTAAdd to Basket

« Hide

MIEKAISRRI KEFRQLGEKG EVEFDFRPFL DFSVKATIRT ELAFCISTAN    50
SSATAGLKFQ RLLGQGVGVK EALTLAGVRF HNRKAEYIRE AFKSFKLVEK 100
ALEAESSKAR EILLKIKGLG MKEASHFLRN VGREDVAIID RHILRWLERQ 150
GYEVPGTMTA KKYLEVEKIL MEISEERGES LAEMDLRIWA EMTGKVLK 198
Length:198
Mass (Da):22,639
Last modified:January 1, 1998 - v1
Checksum:i3A5C033AA12F3FFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB90876.1.
PIRiC69296.
RefSeqiNP_069207.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90876; AAB90876; AF_0371.
GeneIDi1483586.
KEGGiafu:AF0371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000782 Genomic DNA. Translation: AAB90876.1 .
PIRi C69296.
RefSeqi NP_069207.1. NC_000917.1.

3D structure databases

ProteinModelPortali O29876.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224325.AF0371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB90876 ; AAB90876 ; AF_0371 .
GeneIDi 1483586.
KEGGi afu:AF0371.

Phylogenomic databases

eggNOGi COG1059.
KOi K03653.
OMAi SEACFCI.

Enzyme and pathway databases

BioCyci AFUL224325:GJBC-381-MONOMER.

Family and domain databases

Gene3Di 1.10.340.30. 1 hit.
HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiOGG1_ARCFU
AccessioniPrimary (citable) accession number: O29876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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