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O29876

- OGG1_ARCFU

UniProt

O29876 - OGG1_ARCFU

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.By similarity

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei122 – 1221By similarity

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciAFUL224325:GJBC-381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyase
    Including the following 2 domains:
    8-oxoguanine DNA glycosylase (EC:3.2.2.-)
    DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
    Short name:
    AP lyase
    Gene namesi
    Name:ogg
    Ordered Locus Names:AF_0371
    OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
    Taxonomic identifieri224325 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000002199: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Probable N-glycosylase/DNA lyasePRO_0000159563Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224325.AF0371.

    Structurei

    3D structure databases

    ProteinModelPortaliO29876.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.Curated

    Phylogenomic databases

    eggNOGiCOG1059.
    KOiK03653.
    OMAiSEACFCI.

    Family and domain databases

    Gene3Di1.10.340.30. 1 hit.
    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PfamiPF00730. HhH-GPD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O29876-1 [UniParc]FASTAAdd to Basket

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    MIEKAISRRI KEFRQLGEKG EVEFDFRPFL DFSVKATIRT ELAFCISTAN    50
    SSATAGLKFQ RLLGQGVGVK EALTLAGVRF HNRKAEYIRE AFKSFKLVEK 100
    ALEAESSKAR EILLKIKGLG MKEASHFLRN VGREDVAIID RHILRWLERQ 150
    GYEVPGTMTA KKYLEVEKIL MEISEERGES LAEMDLRIWA EMTGKVLK 198
    Length:198
    Mass (Da):22,639
    Last modified:January 1, 1998 - v1
    Checksum:i3A5C033AA12F3FFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB90876.1.
    PIRiC69296.
    RefSeqiNP_069207.1. NC_000917.1.

    Genome annotation databases

    EnsemblBacteriaiAAB90876; AAB90876; AF_0371.
    GeneIDi1483586.
    KEGGiafu:AF0371.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB90876.1 .
    PIRi C69296.
    RefSeqi NP_069207.1. NC_000917.1.

    3D structure databases

    ProteinModelPortali O29876.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224325.AF0371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB90876 ; AAB90876 ; AF_0371 .
    GeneIDi 1483586.
    KEGGi afu:AF0371.

    Phylogenomic databases

    eggNOGi COG1059.
    KOi K03653.
    OMAi SEACFCI.

    Enzyme and pathway databases

    BioCyci AFUL224325:GJBC-381-MONOMER.

    Family and domain databases

    Gene3Di 1.10.340.30. 1 hit.
    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    Pfami PF00730. HhH-GPD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
      Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
      , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
      Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

    Entry informationi

    Entry nameiOGG1_ARCFU
    AccessioniPrimary (citable) accession number: O29876
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3