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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.B5 414
4.2.99.18 414

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:AF_0371
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595631 – 198Probable N-glycosylase/DNA lyaseAdd BLAST198

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0371

Structurei

3D structure databases

ProteinModelPortaliO29876
SMRiO29876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiarCOG04357 Archaea
COG1059 LUCA
KOiK03653
OMAiGYKEASH
OrthoDBiPOG093Z0AOL

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 1 hit
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

O29876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEKAISRRI KEFRQLGEKG EVEFDFRPFL DFSVKATIRT ELAFCISTAN
60 70 80 90 100
SSATAGLKFQ RLLGQGVGVK EALTLAGVRF HNRKAEYIRE AFKSFKLVEK
110 120 130 140 150
ALEAESSKAR EILLKIKGLG MKEASHFLRN VGREDVAIID RHILRWLERQ
160 170 180 190
GYEVPGTMTA KKYLEVEKIL MEISEERGES LAEMDLRIWA EMTGKVLK
Length:198
Mass (Da):22,639
Last modified:January 1, 1998 - v1
Checksum:i3A5C033AA12F3FFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90876.1
PIRiC69296
RefSeqiWP_010877878.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB90876; AAB90876; AF_0371
GeneIDi24793910
KEGGiafu:AF_0371

Similar proteinsi

Entry informationi

Entry nameiOGG1_ARCFU
AccessioniPrimary (citable) accession number: O29876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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