Acetyl-CoA decarbonylase/synthase complex subunit beta - Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Acetyl-CoA decarbonylase/synthase complex subunit beta
Short name=ACDS complex subunit beta
EC=2.3.1.-

Alternative name(s):
ACDS complex acyltransferase

Gene names

Name:	cdhC
Ordered Locus Names:	AF_0379

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO₂ By similarity. HAMAP MF_01138
Catalytic activity	Acetyl-CoA + [acetyl-CoA decarbonylase/synthase complex beta subunit] = CoA + acetyl-[acetyl-CoA decarbonylase/synthase complex beta subunit]. HAMAP MF_01138
Cofactor	Binds 1 nickel-iron-sulfur cluster By similarity. HAMAP MF_01138
Subunit structure	Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha₂epsilon₂)(4)-beta(8)-(gamma₁delta₁)₈ Potential.
Sequence similarities	Belongs to the CdhC family.

Ontologies

Keywords
Ligand	Iron Iron-sulfur Metal-binding Nickel
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbon-monoxide dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: InterPro iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed Ref.2

Chain

2 – 524

523

Acetyl-CoA decarbonylase/synthase complex subunit beta HAMAP MF_01138

PRO_0000155098

Regions

Compositional bias

438 – 450

13

Glu-rich HAMAP MF_01138

Sites

Metal binding

212

1

Nickel-iron-sulfur Potential

Metal binding

215

1

Nickel-iron-sulfur Potential

Metal binding

301

1

Nickel-iron-sulfur Potential

Metal binding

303

1

Nickel-iron-sulfur Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O29868 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 634ACE1C34A83F6A
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FASTA

524

58,576

        10         20         30         40         50         60 
MVERKRIEIP EGVKVKESVG EEAEFPFDIS PMYEGERIRK GDMYVELGGP TQPGFELVMA 

        70         80         90        100        110        120 
LPMDQVEDMK VTLIGPDLDE MEEGQAYPYA MIYYIAGEMV ETDLEPVIER RNHDFQNYIE 

       130        140        150        160        170        180 
GYMHLNQRYD IWIRIGKNAI KKGLKSLIQI AKATMMLYKN ELPFIEKIEA VYITDKDLVE 

       190        200        210        220        230        240 
KLLNELAMPI FEERDARVEA LSDEDVDEFY SCTLCQSFAP TNVCIVSPDR PSLCGAITWF 

       250        260        270        280        290        300 
DGRAAAKVDP EGPNRAVPKG ELLDPIGGEY SGVNEFAKQE SGGEYERIKL HSFFEYPHTS 

       310        320        330        340        350        360 
CGCFEVIGFY MPEVDGIGWV HRGYAEPAPN GLTFSTMAGQ TGGGKQVVGF LGIGIAYFRS 

       370        380        390        400        410        420 
KKFIQADGGW YRTVWMPKEL KERVAKYIPD DIRDKIATEE DAKTLDELRE FLKKVDHPVV 

       430        440        450        460        470        480 
KGVVRPVDGK KITNGWVEEE EEEAEEVAEE AAAEAAPAAQ PAQAAQPMAM QPMPMQMPGF 

       490        500        510        520 
QLPALQMPAA SAAPAGVKLV IKDAKITIEK VIIKKAEKEK KGGK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
[2]	"Acetyl-CoA decarbonylase/synthase complex from Archaeoglobus fulgidus." Dai Y.R., Reed D.W., Millstein J.H., Hartzell P.L., Grahame D.A., DeMoll E. Arch. Microbiol. 169:525-529(1998) [PubMed: 9575239] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-23. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90857.1.
PIR	C69297.
RefSeq	NP_069215.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29868.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483594.
GenomeReviews	Gene locus AF_0379 in contig AE000782_GR.
KEGG	afu:AF0379.
NMPDR	fig\|224325.1.peg.374.
TIGR	AF_0379.
Phylogenomic databases
HOGENOM	HBG456963.
OMA	CPHTSCG.
ProtClustDB	PRK04456.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0379-MONOMER.
Family and domain databases
HAMAP	MF_01138. CdhC. [Tree]
InterPro	IPR004461. CO_DH/Ac-CoA_synth_bsu. IPR023432. CO_DH/Ac-CoA_synth_bsu_arc. IPR011254. Prismane-like. [Graphical view]
KO	K00193.
Pfam	PF03598. CdhC. 1 hit. [Graphical view]
SUPFAM	SSF56821. Prismane_like. 1 hit.
TIGRFAMs	TIGR00316. CdhC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDB_ARCFU

Accession

Primary (citable) accession number: O29868

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 70 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents