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Protein

Geranylgeranylglyceryl phosphate synthase

Gene

AF_0403

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. To a much lesser extent, is also able to use heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) as the prenyl donor.4 Publications

Catalytic activityi

Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation4 Publications

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei11Glycerol-1-phosphateUniRule annotationCombined sources1 Publication1
Metal bindingi13MagnesiumUniRule annotation1
Metal bindingi39MagnesiumUniRule annotation1
Binding sitei195Glycerol-1-phosphate; via amide nitrogenUniRule annotationCombined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranylglyceryl phosphate synthaseUniRule annotationCurated (EC:2.5.1.41UniRule annotation4 Publications)
Short name:
AfGGGPS1 Publication
Short name:
GGGP synthase1 PublicationUniRule annotation
Short name:
GGGPSUniRule annotationCurated
Alternative name(s):
(S)-3-O-geranylgeranylglyceryl phosphate synthaseUniRule annotationCurated
Phosphoglycerol geranylgeranyltransferaseUniRule annotationCurated
Gene namesi
Ordered Locus Names:AF_0403
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99W → A: Increased efficiency with HepPP as substrate, wich becomes similar to that of B.subtilis PcrB. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001387281 – 231Geranylgeranylglyceryl phosphate synthaseAdd BLAST231

Interactioni

Subunit structurei

Homodimer.3 Publications

Protein-protein interaction databases

STRINGi224325.AF0403.

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi8 – 12Combined sources5
Helixi20 – 27Combined sources8
Turni28 – 30Combined sources3
Beta strandi32 – 36Combined sources5
Helixi44 – 54Combined sources11
Beta strandi61 – 63Combined sources3
Beta strandi75 – 83Combined sources9
Beta strandi86 – 88Combined sources3
Turni89 – 93Combined sources5
Helixi94 – 101Combined sources8
Helixi102 – 106Combined sources5
Helixi107 – 115Combined sources9
Beta strandi119 – 126Combined sources8
Helixi132 – 136Combined sources5
Helixi145 – 157Combined sources13
Beta strandi162 – 167Combined sources6
Helixi175 – 184Combined sources10
Beta strandi186 – 194Combined sources9
Helixi199 – 208Combined sources10
Beta strandi209 – 214Combined sources6
Helixi216 – 221Combined sources6
Helixi223 – 227Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F6UX-ray1.55A/B1-231[»]
2F6XX-ray2.00A/B1-231[»]
ProteinModelPortaliO29844.
SMRiO29844.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29844.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 170Glycerol-1-phosphate bindingUniRule annotationCombined sources1 Publication6
Regioni215 – 216Glycerol-1-phosphate bindingUniRule annotationCombined sources1 Publication2

Sequence similaritiesi

Belongs to the GGGP/HepGP synthase family. Group I subfamily.UniRule annotation1 Publication

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
KOiK17104.
OMAiIVYIEYS.

Family and domain databases

CDDicd02812. PcrB_like. 1 hit.
Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR026438. GGGP_synthase_archaea.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01768. GGGP-family. 1 hit.
TIGR04146. GGGPS_Afulg. 1 hit.

Sequencei

Sequence statusi: Complete.

O29844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWRKWRHIT KLDPDRTNTD EIIKAVADSG TDAVMISGTQ NVTYEKARTL
60 70 80 90 100
IEKVSQYGLP IVVEPSDPSN VVYDVDYLFV PTVLNSADGD WITGKHAQWV
110 120 130 140 150
RMHYENLQKF TEIIESEFIQ IEGYIVLNPD SAVARVTKAL CNIDKELAAS
160 170 180 190 200
YALVGEKLFN LPIIYIEYSG TYGNPELVAE VKKVLDKARL FYGGGIDSRE
210 220 230
KAREMLRYAD TIIVGNVIYE KGIDAFLETL P
Length:231
Mass (Da):26,144
Last modified:January 1, 1998 - v1
Checksum:i935D2D657550ABDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90827.1.
PIRiC69300.
RefSeqiWP_010877910.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90827; AAB90827; AF_0403.
GeneIDi24793941.
KEGGiafu:AF_0403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90827.1.
PIRiC69300.
RefSeqiWP_010877910.1. NC_000917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F6UX-ray1.55A/B1-231[»]
2F6XX-ray2.00A/B1-231[»]
ProteinModelPortaliO29844.
SMRiO29844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0403.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90827; AAB90827; AF_0403.
GeneIDi24793941.
KEGGiafu:AF_0403.

Phylogenomic databases

eggNOGiarCOG01085. Archaea.
COG1646. LUCA.
KOiK17104.
OMAiIVYIEYS.

Enzyme and pathway databases

UniPathwayiUPA00940.

Miscellaneous databases

EvolutionaryTraceiO29844.

Family and domain databases

CDDicd02812. PcrB_like. 1 hit.
Gene3Di3.20.20.390. 1 hit.
HAMAPiMF_00112. GGGP_HepGP_synthase. 1 hit.
InterProiIPR008205. GGGP_HepGP_synthase.
IPR026438. GGGP_synthase_archaea.
[Graphical view]
PfamiPF01884. PcrB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01768. GGGP-family. 1 hit.
TIGR04146. GGGPS_Afulg. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGGGPS_ARCFU
AccessioniPrimary (citable) accession number: O29844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.