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Protein

Proteasome subunit alpha

Gene

psmA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.973

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome alpha subunitUniRule annotation
Proteasome core protein PsmAUniRule annotation
Gene namesi
Name:psmAUniRule annotation
Ordered Locus Names:AF_0490
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241671 – 246Proteasome subunit alphaAdd BLAST246

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has probably a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is likely capped at one or both ends by the proteasome regulatory ATPase, PAN.1 Publication

Protein-protein interaction databases

IntActiO29760, 1 interactor
STRINGi224325.AF0490

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Helixi22 – 32Combined sources11
Beta strandi37 – 42Combined sources6
Beta strandi45 – 51Combined sources7
Helixi61 – 63Combined sources3
Beta strandi66 – 69Combined sources4
Beta strandi71 – 80Combined sources10
Helixi82 – 102Combined sources21
Beta strandi103 – 105Combined sources3
Helixi109 – 122Combined sources14
Turni123 – 125Combined sources3
Beta strandi127 – 129Combined sources3
Beta strandi134 – 150Combined sources17
Beta strandi156 – 165Combined sources10
Helixi168 – 178Combined sources11
Helixi185 – 200Combined sources16
Helixi206 – 208Combined sources3
Beta strandi209 – 215Combined sources7
Turni216 – 218Combined sources3
Helixi226 – 243Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2PX-ray2.60A/B/C/D/E/F/G1-246[»]
1J2QX-ray2.83A/B/C/D/E/F/G10-246[»]
ProteinModelPortaliO29760
SMRiO29760
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29760

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00971 Archaea
COG0638 LUCA
KOiK03432
OMAiFQVEYAR
OrthoDBiPOG093Z086S

Family and domain databases

CDDicd03756 proteasome_alpha_archeal, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00289_A Proteasome_A_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR019982 Proteasome_asu_arc
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03633 arc_protsome_A, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O29760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLPQMGYDR AITVFSPDGR LFQVEYAREA VKRGATAIGI KCKEGVILIA
60 70 80 90 100
DKRVGSKLLE ADTIEKIYKI DEHICAATSG LVADARVLID RARIEAQINR
110 120 130 140 150
LTYDEPITVK ELAKKICDFK QQYTQYGGVR PFGVSLLIAG VDEVPKLYET
160 170 180 190 200
DPSGALLEYK ATAIGMGRNA VTEFFEKEYR DDLSFDDAMV LGLVAMGLSI
210 220 230 240
ESELVPENIE VGYVKVDDRT FKEVSPEELK PYVERANERI RELLKK
Length:246
Mass (Da):27,599
Last modified:January 1, 1998 - v1
Checksum:i9F24A7F120ADBE5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90747.1
PIRiB69311
RefSeqiWP_010877997.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB90747; AAB90747; AF_0490
GeneIDi24794030
KEGGiafu:AF_0490

Similar proteinsi

Entry informationi

Entry nameiPSA_ARCFU
AccessioniPrimary (citable) accession number: O29760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health