Reviewed, UniProtKB/Swiss-Prot O29730 (AROK_ARCFU)

Names and origin

Protein names

Recommended name:
    Shikimate kinase
      Short name=SK
    EC=2.7.1.71

Gene names

Name:	aroK
Ordered Locus Names:	AF_0520

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP MF_00370
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP MF_00370
Subcellular location	Cytoplasm Probable HAMAP MF_00370.
Sequence similarities	Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP shikimate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Shikimate kinase HAMAP MF_00370		PRO_0000141571
Regions
	Nucleotide binding	74 – 84	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	O29730-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 968F51E6FF8643D1	FASTA	280	30,614
	10 20 30 40 50 60 MMRAKAYAAG TVLNALPTGI GSAFGIEMHT IVKLRPSDEL KVFVNGVERR SIVAERILNS 70 80 90 100 110 120 MDVTAEVIVE SEIPGGSGLG SSSAFVNALI CAVKKMKGEE LNAFEILRSN ARFSLEAGIS 130 140 150 160 170 180 YTGAFDDASA SMLGGFVVSD NRKMRLIRTD EFEGYSAVLI PKFSRGKVDW RRLRERASEV 190 200 210 220 230 240 EGAVEAAMRG EYCKAMKLNT EYICKMLGYP LEIAEKGWEK GICCGISGNG PSYVAFGSKN 250 260 270 280 EMEALAETWG EYGRVYVRRV ADEPAEDVVI PTPFFRKLDG

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90713.1.
PIR	H69314.
RefSeq	NP_069356.1.
3D structure databases
SMR	O29730. Positions 64-259.
ModBase	Search...
Genome annotation databases
GeneID	1483737.
GenomeReviews	Gene locus AF_0520 in contig AE000782_GR.
KEGG	afu:AF0520.
NMPDR	fig|224325.1.peg.515.
TIGR	AF_0520.
Phylogenomic databases
HOGENOM	HBG646614.
OMA	VTGAYDD.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0520-MONOMER.
BRENDA	2.7.1.71. 7576.
Family and domain databases
HAMAP	MF_00370. Shik_kinase_arch. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR006203. GHMP_knse_ATP_bd_CS. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR010189. SK_arc. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF005758. Shikimt_kin_arch. 1 hit.
TIGRFAMs	TIGR01920. Shik_kin_archae. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROK_ARCFU

Accession

Primary (citable) accession number: O29730

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	January 1, 1998
Last modified:	February 9, 2010
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)