O29703 (SYT_ARCFU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 84.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Threonine--tRNA ligase EC=6.1.1.3 Alternative name(s): Threonyl-tRNA synthetase Short name=ThrRS | ||||
| Gene names |
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| Organism | Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) | ||||
| Taxonomic identifier | 224325 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus |
Protein attributes
| Sequence length | 619 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP MF_00184 |
| Cofactor | Binds 1 zinc ion per subunit By similarity. HAMAP MF_00184 |
| Subcellular location | |
| Sequence similarities | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Metal-binding Nucleotide-binding Zinc |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | threonyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW threonine-tRNA ligase activityInferred from electronic annotation. Source: EC zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 619 | 619 | Threonine--tRNA ligase HAMAP MF_00184 | PRO_0000101097 | |||||
Regions | |||||||||
| Region | 196 – 495 | 300 | Catalytic HAMAP MF_00184 | ||||||
Sites | |||||||||
| Metal binding | 288 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 340 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 464 | 1 | Zinc; catalytic By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. Venter J.C.Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000782 Genomic DNA. Translation: AAB90685.1. |
| PIR | D69318. |
| RefSeq | NP_069384.1. NC_000917.1. |
3D structure databases | |
| ProteinModelPortal | O29703. |
| SMR | O29703. Positions 1-134. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1483764. |
| GenomeReviews | Gene locus AF_0548 in contig AE000782_GR. |
| KEGG | afu:AF0548. |
| NMPDR | fig|224325.1.peg.543. |
| TIGR | AF_0548. |
Phylogenomic databases | |
| HOGENOM | HBG392335. |
| OMA | ETPVMYD. |
| ProtClustDB | PRK03991. |
Enzyme and pathway databases | |
| BioCyc | AFUL224325:AF_0548-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00184. Thr_tRNA_synth. [Tree] |
| InterPro | IPR002314. aa-tRNA-synt_IIb_cons-dom. IPR006195. aa-tRNA-synth_II. IPR004154. Anticodon-bd. IPR002320. Thr-tRNA-synth_IIa. IPR015011. Threonyl-tRNA_syn_edit_dom_arc. [Graphical view] |
| Gene3D | G3DSA:3.40.50.800. Anticodon_bd. 1 hit. |
| KO | K01868. |
| Pfam | PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF08915. tRNA-Thr_ED. 1 hit. [Graphical view] |
| PRINTS | PR01047. TRNASYNTHTHR. |
| ProDom | PD016189. Threonyl-tRNA_syntase_arc. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SUPFAM | SSF52954. Anticodon_bd. 1 hit. |
| TIGRFAMs | TIGR00418. ThrS. 1 hit. |
| PROSITE | PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYT_ARCFU | ||||||||
| Accession | Primary (citable) accession number: O29703 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

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