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O29689 (ISCS2_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cysteine desulfurase 2
EC=2.8.1.7
Gene names
Name:iscS2
Ordered Locus Names:AF_0564
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus ›

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the removal of elemental sulfur from cysteine to produce alanine By similarity. HAMAP-Rule MF_00331

Catalytic activity

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor. HAMAP-Rule MF_00331

Cofactor

Pyridoxal phosphate By similarity.

Sequence similarities

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

Caution

The conserved pyridoxal-binding site Lys at position 199 is replaced by an Asp.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Probable cysteine desulfurase 2 HAMAP-Rule MF_00331
PRO_0000150288

Sites

Active site3211Cysteine persulfide intermediate By similarity

Secondary structure

1 .......................................................... 382
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O29689 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 3B2A25229124C02A

FASTA38241,824
        10         20         30         40         50         60 
MAYFDYTSAK PVDERVLEAM LPYMTESFGN PSSVHSYGFK AREAVQEARE KVAKLVNGGG 

        70         80         90        100        110        120 
GTVVFTSGAT EANNLAIIGY AMRNARKGKH ILVSAVEHMS VINPAKFLQK QGFEVEYIPV 

       130        140        150        160        170        180 
GKYGEVDVSF IDQKLRDDTI LVSVQHANNE IGTIQPVEEI SEVLAGKAAL HIDATASVGQ 

       190        200        210        220        230        240 
IEVDVEKIGA DMLTISSNDI YGPKGVGALW IRKEAKLQPV ILGGGQENGL RSGSENVPSI 

       250        260        270        280        290        300 
VGFGKAAEIT AMEWREEAER LRRLRDRIID NVLKIEESYL NGHPEKRLPN NVNVRFSYIE 

       310        320        330        340        350        360 
GESIVLSLDM AGIQASTGSA CSSKTLQPSH VLMACGLKHE EAHGTLLLTL GRYNTDEDVD 

       370        380 
RLLEVLPGVI ERLRSMSPLY RR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB90671.1.
PIRD69320.
RefSeqNP_069398.1. NC_000917.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4EB5X-ray2.53A/B1-382[»]
4EB7X-ray2.75A/B1-382[»]
4HVKX-ray1.43A1-382[»]
ProteinModelPortalO29689.
ModBaseSearch...

Protein-protein interaction databases

STRING224325.AF0564.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90671; AAB90671; AF_0564.
GeneID1483780.
KEGGafu:AF0564.

Phylogenomic databases

eggNOGCOG1104.
KOK04487.
OMADAQGIAC.
ProtClustDBCLSK541355.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-577-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00331. Cys_desulf_aminotr_5.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF005572. NifS. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00595. AA_TRANSFER_CLASS_5. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISCS2_ARCFU
AccessionPrimary (citable) accession number: O29689
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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