O29666 (KPRS1_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-phosphate pyrophosphokinase 1
Short name=RPPK 1
EC=2.7.6.1

Alternative name(s):
Phosphoribosyl pyrophosphate synthase 1
Short name=P-Rib-PP synthase 1
Short name=PRPP synthase 1

Gene names

Name:	prs1
Synonyms:	prsA-1
Ordered Locus Names:	AF_0589

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_A
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_A
Pathway	Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_A
Subcellular location	Cytoplasm By similarity HAMAP MF_00583_A.
Sequence similarities	Belongs to the ribose-phosphate pyrophosphokinase family.
Sequence caution	The sequence AAB90651.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro ribose phosphate diphosphokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	Ribose-phosphate pyrophosphokinase 1 HAMAP MF_00583_A		PRO_0000141234
Regions
	Region	205 – 217	13	Binding of phosphoribosylpyrophosphate Potential
Sites
	Metal binding	124	1	Magnesium Potential
	Metal binding	126	1	Magnesium Potential

Sequences

	Sequence		Length	Mass (Da)
	O29666 [UniParc]. Last modified October 25, 2002. Version 2. Checksum: 2003F65B6CC8CA0B	FASTA	284	30,791
	10 20 30 40 50 60 MVILVGGTNG LMALKVAKIS GLPLCYSHVD RYPDGEKYFR FASNIDGEDV VIFNSMHPNP 70 80 90 100 110 120 DEIIFETLLI AETAYSNGAR SVTCVFPYFA YARSLDTVKG EALPIKTVVK VLKAAGVKKI 130 140 150 160 170 180 ITVDFHLQEN VFGVEHVDLT GMEKLAEYCL EEFSDSFTVL APDEKAAFWA EKFAAKANCD 190 200 210 220 230 240 VVALRKIRID AENVIIDDLR TGVEGDVVIV DDIVSTGGTV CQAARIAKRA GARRVFVACT 250 260 270 280 HAILARDAMM RILESGIEDI VSTDTILSPV SHVSVADVIA SALS

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90651.1. Different initiation.
PIR	E69323.
RefSeq	NP_069423.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29666.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483806.
GenomeReviews	Gene locus AF_0589 in contig AE000782_GR.
KEGG	afu:AF0589.
NMPDR	fig|224325.1.peg.582.
TIGR	AF_0589.
Phylogenomic databases
HOGENOM	HBG519284.
OMA	ATRILAC.
ProtClustDB	CLSK2746495.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0589-MONOMER.
Family and domain databases
HAMAP	MF_00583_A. RibP_PPkinase_A. [Tree]
InterPro	IPR000836. PRibTrfase. IPR005946. Rib-P_diPkinase. [Graphical view]
KO	K00948.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01251. RibP_PPkin. 1 hit.
PROSITE	PS00114. PRPP_SYNTHASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPRS1_ARCFU

Accession

Primary (citable) accession number: O29666

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	October 25, 2002
Last modified:	November 16, 2011
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program