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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi107 – 111GTPBy similarity5
Nucleotide bindingi163 – 166GTPBy similarity4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gamma
Alternative name(s):
aIF2-gamma
eIF-2-gamma
Gene namesi
Name:eif2g
Ordered Locus Names:AF_0592
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374501 – 424Translation initiation factor 2 subunit gammaAdd BLAST424

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.By similarity

Protein-protein interaction databases

STRINGi224325.AF0592.

Structurei

3D structure databases

ProteinModelPortaliO29663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 220tr-type GAdd BLAST198

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 39G1By similarity8
Regioni60 – 64G2By similarity5
Regioni107 – 110G3By similarity4
Regioni163 – 166G4By similarity4
Regioni198 – 200G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O29663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRNPSTFKY IPLRIDFMSE VPLPEVNIGL VGHVDHGKTT LVAALSGVWT
60 70 80 90 100
DRHSEELKRG ISIKLGYADA TFRKCPECEP PEAYTVEEIC PIHGVETEIL
110 120 130 140 150
RTVSFVDSPG HEMLMATMLS GAAIMDGAVL VIAANEKCPR PQTKEHLMAL
160 170 180 190 200
QIIGIDKIVI AQNKIDIVSR ERVLENYQEI KEFVKGTVAE NAPIIPISAQ
210 220 230 240 250
QKVNMDALIE AIEETIPTPE RDLDSPPLMH VARSFDVNKP GTPPEKLLGG
260 270 280 290 300
VLGGSLSRGR IRVGDEIEIR PGVKDERGNW NPLFTEVQSI VASGRFVDEA
310 320 330 340 350
TPGGLVGIAT KLDPTLTKSD ALVGNVVGHP GNLPDVLTSF TMEVNLLERV
360 370 380 390 400
VGLDEEMEVE KIKMNEPLML AVGTAITLGV VTSARDDIVE VKLRRPVCAD
410 420
KGSRVAISRR VGSRWRLIGA GIIR
Length:424
Mass (Da):46,271
Last modified:January 1, 1998 - v1
Checksum:iC138F922A637CE15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90649.1.
PIRiH69323.

Genome annotation databases

EnsemblBacteriaiAAB90649; AAB90649; AF_0592.
KEGGiafu:AF_0592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90649.1.
PIRiH69323.

3D structure databases

ProteinModelPortaliO29663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90649; AAB90649; AF_0592.
KEGGiafu:AF_0592.

Phylogenomic databases

eggNOGiarCOG01563. Archaea.
COG5257. LUCA.
KOiK03242.
OMAiWTDRHSE.

Family and domain databases

CDDicd15490. eIF2_gamma_III. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00119. eIF_2_gamma. 1 hit.
InterProiIPR004161. EFTu-like_2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR022424. TIF2_gsu.
IPR015256. TIF2_gsu_C.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF09173. eIF2_C. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03680. eif2g_arch. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF2G_ARCFU
AccessioniPrimary (citable) accession number: O29663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.