O29573 (DHSD_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase hydrophobic membrane anchor subunit

Gene names

Name:	sdhD
Ordered Locus Names:	AF_0684

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Membrane-anchoring subunit of succinate dehydrogenase (SDH) By similarity.
Cofactor	Heme group. The heme is bound between the two transmembrane subunits By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, sdhC and sdhD By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the CH-CH group of donors Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 117	117	Succinate dehydrogenase hydrophobic membrane anchor subunit		PRO_0000158679
Regions
	Topological domain	1 – 15	15	Cytoplasmic Potential
	Transmembrane	16 – 36	21	Helical; Potential
	Topological domain	37 – 61	25	Extracellular Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Topological domain	83 – 92	10	Cytoplasmic Potential
	Transmembrane	93 – 115	23	Helical; Potential
Sites
	Metal binding	73	1	Iron (heme axial ligand); shared with second transmembrane subunit By similarity

Sequences

	Sequence		Length	Mass (Da)
	O29573 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 7289CF814F52B7D3	FASTA	117	13,100
	10 20 30 40 50 60 MVEMESAKSV LEPLAWLMQM ITGLLMILLV TAHFYVTHMT THDALRYAEV VERVAQPEFK 70 80 90 100 110 ALYALLLLAV SFHAFNGLRA ILLDTNAGMR KKGAVSALTT LAFLLAFFYG LYLLFSI

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90554.1.
PIR	D69335.
RefSeq	NP_069518.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29573.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1483902.
GenomeReviews	Gene locus AF_0684 in contig AE000782_GR.
KEGG	afu:AF0684.
NMPDR	fig|224325.1.peg.677.
TIGR	AF_0684.
Phylogenomic databases
ProtClustDB	CLSK2746543.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0684-MONOMER.
Family and domain databases
InterPro	IPR000701. Succ_DH_Fumarate_Rdtase_TM-su. [Graphical view]
KO	K00242.
Pfam	PF01127. Sdh_cyt. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSD_ARCFU

Accession

Primary (citable) accession number: O29573

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program