Reviewed, UniProtKB/Swiss-Prot O29525 (THIL_ARCFU)

Names and origin

Protein names

Recommended name:
    Probable thiamine-monophosphate kinase
      Short name=Thiamine-phosphate kinase
    EC=2.7.4.16

Gene names

Name:	thiL
Ordered Locus Names:	AF_0733

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + thiamine phosphate = ADP + thiamine diphosphate.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.
Sequence similarities	Belongs to the thiamine-monophosphate kinase family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin phosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Probable thiamine-monophosphate kinase		PRO_0000096200

Sequences

	Sequence		Length	Mass (Da)
	O29525-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 409D5FECC306E18C	FASTA	296	32,784
	10 20 30 40 50 60 MFYANMKEFE LIKLVERLFG DEDVITPAGK HDAAYVKIGN RLIVLTCDTV NEKSDFPPYM 70 80 90 100 110 120 LPEEMGWMAI AVTLSDVAAC GARPLYFLSS ISLKSIEFFE DILLGIKRCA DRFGVKVVGG 130 140 150 160 170 180 DIDFSEITTI AGFAIGEARR HITRRGAKVG EGVFITDLPG KAQLCLEMLE RGAKREELPY 190 200 210 220 230 240 AEKLYTPVPR IEEGMRIARY ASAMTDVSDS LAVSLHQISQ SSNVKIVLDN IVLSHLSPAE 250 260 270 280 290 NALELFLYGG GDFELVYTAK SSDDGIRIGR VERGKGVFAE IDGKTFEVEF RGYSHF

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000782 Genomic DNA. Translation: AAB90505.1.
PIR	E69341.
RefSeq	NP_069567.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1483951.
GenomeReviews	Gene locus AF_0733 in contig AE000782_GR.
KEGG	afu:AF0733.
NMPDR	fig|224325.1.peg.726.
TIGR	AF_0733.
Phylogenomic databases
HOGENOM	O29525.
OMA	IDSHIEL.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0733-MON.
BRENDA	2.7.4.16. 7576.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR006283. ThiL. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. [Graphical view]
PIRSF	PIRSF005303. Thiam_monoph_kin. 1 hit.
TIGRFAMs	TIGR01379. thiL. 1 hit.
ProtoNet	Search...

Entry information

Entry name

THIL_ARCFU

Accession

Primary (citable) accession number: O29525

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)