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O29511 (DAPF_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diaminopimelate epimerase

Short name=DAP epimerase
EC=5.1.1.7
Gene names
Name:dapF
Ordered Locus Names:AF_0747
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine By similarity. HAMAP-Rule MF_00197

Catalytic activity

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP-Rule MF_00197

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP-Rule MF_00197

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00197.

Sequence similarities

Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlysine biosynthetic process via diaminopimelate

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiondiaminopimelate epimerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Diaminopimelate epimerase HAMAP-Rule MF_00197
PRO_0000149885

Regions

Region76 – 783Substrate binding By similarity
Region208 – 2092Substrate binding By similarity
Region219 – 2202Substrate binding By similarity

Sites

Active site761Proton donor/acceptor By similarity
Active site2181Proton donor/acceptor By similarity
Binding site131Substrate By similarity
Binding site491Substrate By similarity
Binding site671Substrate By similarity
Binding site1911Substrate By similarity
Site1611Important for catalytic activity By similarity
Site2081Important for catalytic activity By similarity

Amino acid modifications

Disulfide bond76 ↔ 218 HAMAP-Rule MF_00197

Sequences

Sequence LengthMass (Da)Tools
O29511 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1DE1C5FA162EC289

FASTA28031,023
        10         20         30         40         50         60 
MRIAFTKMHG NGNDFVLIDE FEGVIVGEEE KPRFVRAVCH RNFGVGADGA LFVQPSQKAD 

        70         80         90        100        110        120 
VRFRYFNSDG SEAAMCGNGI RCFSRYVVEE GYAGERLRVE TLAGILELEV KRENGWWVKV 

       130        140        150        160        170        180 
DMGKPKFGRE EIPAKTDVWG YEVEHDGRKF RIYAANTGVP HVAVFVDSLD FDIVPLARKI 

       190        200        210        220        230        240 
RYSEIFPEGT NVNFAKVDGD TITVRTYERG VEGETLSCGT GSVAVAAIAN RLGLTGSKVD 

       250        260        270        280 
VVTKGGLLKI ELTEDTAYMT GGASRVFDGI LRLNELRYDI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90492.1.
PIRC69343.
RefSeqNP_069581.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29511.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF0747.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90492; AAB90492; AF_0747.
GeneID1483964.
KEGGafu:AF0747.

Phylogenomic databases

eggNOGCOG0253.
KOK01778.
OMALIVEPPY.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-763-MONOMER.
UniPathwayUPA00034; UER00025.

Family and domain databases

HAMAPMF_00197. DAP_epimerase.
InterProIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERPTHR31689. PTHR31689. 1 hit.
PfamPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsTIGR00652. DapF. 1 hit.
PROSITEPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPF_ARCFU
AccessionPrimary (citable) accession number: O29511
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways