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Protein

tRNA (cytidine(56)-2'-O)-methyltransferase

Gene

AF_0751

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.By similarity

Catalytic activityi

S-adenosyl-L-methionine + cytidine(56) in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(56) in tRNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (cytidine(56)-2'-O)-methyltransferase (EC:2.1.1.206)
Alternative name(s):
tRNA ribose 2'-O-methyltransferase aTrm56
Gene namesi
Ordered Locus Names:AF_0751
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469261 – 168tRNA (cytidine(56)-2'-O)-methyltransferaseAdd BLAST168

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi224325.AF0751

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi16 – 28Combined sources13
Beta strandi32 – 38Combined sources7
Helixi41 – 54Combined sources14
Beta strandi59 – 62Combined sources4
Helixi65 – 71Combined sources7
Beta strandi74 – 79Combined sources6
Beta strandi83 – 85Combined sources3
Helixi86 – 94Combined sources9
Beta strandi97 – 103Combined sources7
Helixi112 – 115Combined sources4
Beta strandi116 – 125Combined sources10
Helixi129 – 140Combined sources12
Turni144 – 146Combined sources3
Beta strandi153 – 157Combined sources5
Beta strandi160 – 162Combined sources3
Beta strandi164 – 166Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O3AX-ray2.20A/B2-168[»]
ProteinModelPortaliO29507
SMRiO29507
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO29507

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 108S-adenosyl-L-methionine bindingBy similarity5

Sequence similaritiesi

Belongs to the aTrm56 family.Curated

Phylogenomic databases

eggNOGiarCOG01857 Archaea
COG1303 LUCA
KOiK07254
OMAiVVHLTMY
OrthoDBiPOG093Z0BT8

Family and domain databases

Gene3Di3.40.1280.10, 1 hit
HAMAPiMF_00077 tRNA_methyltr_aTrm56, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029026 tRNA_m1G_MTases_N
IPR002845 tRNA_mtfrase_aTrm56
PANTHERiPTHR42197 PTHR42197, 1 hit
PfamiView protein in Pfam
PF01994 Trm56, 1 hit
PIRSFiPIRSF016123 UCP016123, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016584 DUF127, 1 hit
SUPFAMiSSF75217 SSF75217, 1 hit

Sequencei

Sequence statusi: Complete.

O29507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVYVLRLGH RPERDKRIST HVALTARAFG AKGIYFDTED KSVFESVRDV
60 70 80 90 100
VERWGGDFFI KAVSWKKLLR EFDGLKVHLT MYGIPLPQKL EEIKRADKVL
110 120 130 140 150
VVVGAEKVPP EVYELCDLNI SIGTQPHSEV AALAVFLDRV LGKVFDISFD
160
DAKIKVIPSE RGKRVVSE
Length:168
Mass (Da):19,026
Last modified:January 1, 1998 - v1
Checksum:iACEDE86A81D3C308
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90489.1
PIRiG69343
RefSeqiWP_010878254.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB90489; AAB90489; AF_0751
GeneIDi24794349
KEGGiafu:AF_0751

Similar proteinsi

Entry informationi

Entry nameiTRM56_ARCFU
AccessioniPrimary (citable) accession number: O29507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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