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Protein

Probable translation initiation factor IF-2

Gene

infB

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi81 – 855GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-784-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:AF_0768
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 595595Probable translation initiation factor IF-2PRO_0000137298Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0768.

Structurei

3D structure databases

ProteinModelPortaliO29490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 225215tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 278G1By similarity
Regioni45 – 495G2By similarity
Regioni81 – 844G3By similarity
Regioni135 – 1384G4By similarity
Regioni203 – 2053G5By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiLSQRYMK.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O29490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKKEEAKA LRTPIVAVLG HVDHGKTTLL DRIRKSKVVA KEAGGITQHI
60 70 80 90 100
GATEVPLDVI KQICKDIWKV EVKIPGLLFI DTPGHKAFTN LRRRGGALAD
110 120 130 140 150
LAILIVDINE GFKPQTEEAL SILRTFKTPF VVAANKIDRI PGWQSHEDTP
160 170 180 190 200
FMKSYAMQED FAKQNLENRL YNLIAELYQR GFSAERFDRI SDFTRTVAVV
210 220 230 240 250
PISALKGEGI PELLLILVGL AQRYLEKNLR LHIEGKGRGT VLEVKEERGL
260 270 280 290 300
GVTCDAILYD GTLKVGDRIA IAGKDEVIVT NVKAILKPPP VREMRVESKF
310 320 330 340 350
QSVKSVTAAA GIKIVAPNLE NVLAGSEFEV VESEEDIKKF EERVRKEYEE
360 370 380 390 400
IAIRTDEEGV VLKTDTLGSL EALINELRQE GIPIKKAEVG DVDKRDVVDA
410 420 430 440 450
SANKDELNKV VLAFNVKLLP GVEEEAKKYG VRIFSHEIIY TLIESFVKWR
460 470 480 490 500
EEERLARERQ KVEALIKPGK IKLLKEFIFR RSKPAIVGVR VLAGELRRGV
510 520 530 540 550
DLIKPDGTKV GAVRTMQKEG KNVAIASAGD ELAIAIEDVT IGRQLEGDEE
560 570 580 590
LYVDVPERHA KVIERDLLDS LDEETKRAFK EFLEIKRKDN PFWGK
Length:595
Mass (Da):66,680
Last modified:January 1, 1998 - v1
Checksum:iAFED672E7D0D9703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90465.1.
PIRiH69345.
RefSeqiWP_010878271.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90465; AAB90465; AF_0768.
GeneIDi1483985.
KEGGiafu:AF_0768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90465.1.
PIRiH69345.
RefSeqiWP_010878271.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO29490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0768.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90465; AAB90465; AF_0768.
GeneIDi1483985.
KEGGiafu:AF_0768.

Phylogenomic databases

eggNOGiarCOG01560. Archaea.
COG0532. LUCA.
KOiK03243.
OMAiLSQRYMK.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-784-MONOMER.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_A. IF_2_A.
InterProiIPR004161. EFTu-like_2.
IPR029459. EFTU-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR004544. TIF_aIF-2_arc.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF14578. GTP_EFTU_D4. 1 hit.
PF11987. IF-2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00491. aIF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiIF2P_ARCFU
AccessioniPrimary (citable) accession number: O29490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.