ID   O29472_ARCFU            Unreviewed;       351 AA.
AC   O29472;
DT   01-JAN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Magnesium transport protein CorA {ECO:0000256|RuleBase:RU362010};
GN   Name=corA {ECO:0000256|RuleBase:RU362010};
GN   OrderedLocusNames=AF_0786 {ECO:0000313|EMBL:AAB90452.1};
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325 {ECO:0000313|EMBL:AAB90452.1, ECO:0000313|Proteomes:UP000002199};
RN   [1] {ECO:0000313|EMBL:AAB90452.1, ECO:0000313|Proteomes:UP000002199}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16
RC   {ECO:0000313|Proteomes:UP000002199};
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.P., Clayton R.A., Tomb J., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B., Peterson S.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L., Utterback T., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
RN   [2] {ECO:0007829|PDB:2HN1}
RP   X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 1-263.
RX   PubMed=16902408; DOI=10.1038/sj.emboj.7601269;
RA   Payandeh J., Pai E.F.;
RT   "A structural basis for Mg2+ homeostasis and the CorA translocation
RT   cycle.";
RL   EMBO J. 25:3762-3773(2006).
CC   -!- FUNCTION: Mediates influx of magnesium ions.
CC       {ECO:0000256|RuleBase:RU362010}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362010}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362010}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|RuleBase:RU362010}.
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DR   EMBL; AE000782; AAB90452.1; -; Genomic_DNA.
DR   PIR; B69348; B69348.
DR   RefSeq; WP_010878289.1; NC_000917.1.
DR   PDB; 2HN1; X-ray; 2.90 A; A=1-263.
DR   PDBsum; 2HN1; -.
DR   AlphaFoldDB; O29472; -.
DR   SMR; O29472; -.
DR   STRING; 224325.AF_0786; -.
DR   PaxDb; 224325-AF_0786; -.
DR   EnsemblBacteria; AAB90452; AAB90452; AF_0786.
DR   GeneID; 24794383; -.
DR   KEGG; afu:AF_0786; -.
DR   eggNOG; arCOG02265; Archaea.
DR   HOGENOM; CLU_007127_0_0_2; -.
DR   OrthoDB; 28779at2157; -.
DR   PhylomeDB; O29472; -.
DR   EvolutionaryTrace; O29472; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd12828; TmCorA-like_1; 1.
DR   Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR   InterPro; IPR045861; CorA_cytoplasmic_dom.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   NCBIfam; TIGR00383; corA; 1.
DR   PANTHER; PTHR46494; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR   PANTHER; PTHR46494:SF1; CORA FAMILY METAL ION TRANSPORTER (EUROFUNG); 1.
DR   Pfam; PF01544; CorA; 1.
DR   SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR   SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2HN1};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU362010};
KW   Ion transport {ECO:0000256|RuleBase:RU362010};
KW   Magnesium {ECO:0000256|RuleBase:RU362010};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362010};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002199};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362010};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362010}; Transport {ECO:0000256|RuleBase:RU362010}.
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362010"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362010"
SQ   SEQUENCE   351 AA;  40272 MW;  E9790B12B780AC87 CRC64;
     MRIPATIKKK MALPPATPVF TGEKKVEETK ITAAIYDEKS VEFKELEVGE LESVVRSALA
     LNKKLWIDVV GVHDESLIAK ICEFLGIHPL AAEDILNTAQ RVKIEDYDDH LFLVLKILLY
     NETLEIDQLS LVLKKNLVAT FEEREYWILD SIRSRLKSGG RMRKLAGDYL AYTILDAVVD
     SYFEALLKIS DEIEVLEDEV VSGDSTLIGK IHSLKREILA FRNAVWPLRD VLSFFTRVEH
     ELIGEEVKVY YRDVYDHAVR LMEVLETQRE LLVSLRDLFL SAVSNKLNEI MKVLTMIATI
     FIPLSFIAGV YGMNFKYMPE LEWKYGYPAV LTVMAVIALV MIAFFRRKGW L
//