Reviewed, UniProtKB/Swiss-Prot O29445 (SERA_ARCFU)

Names and origin

Protein names

Recommended name:
    D-3-phosphoglycerate dehydrogenase
      Short name=PGDH
    EC=1.1.1.95

Gene names

Name:	serA
Ordered Locus Names:	AF_0813

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. 2-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH.
Pathway	Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glyceric acid: step 1/3.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro phosphoglycerate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	D-3-phosphoglycerate dehydrogenase		PRO_0000076008
Regions
	Domain	452 – 525	74	ACT
Sites
	Active site	230	1	By similarity
	Active site	259	1	By similarity
	Active site	278	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	O29445-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D2464729D04004A9	FASTA	527	57,204
	10 20 30 40 50 60 MKVLVAEPIS EEAIDYMRKN GLEVEVKTGM SREELIREVP KYEAIVVRSQ TKVDAEVIQA 70 80 90 100 110 120 AKNLKIIGRA GVGVDNIDIN AATQRGIVVV NAPGGNTIST AEHAIALMLA AARKIPQADR 130 140 150 160 170 180 SVKEGKWERK KFMGIELRGK TAGVIGLGRV GFEVAKRCKA LEMNVLAYDP FVSKERAEQI 190 200 210 220 230 240 GVKLVDFDTL LASSDVITVH VPRTKETIGL IGKGQFEKMK DGVIVVNAAR GGIVDEAALY 250 260 270 280 290 300 EAIKAGKVAA AALDVYEKEP PSPDNPLLKL DNVVTTPHIA ASTREAQLNV GMIIAEDIVN 310 320 330 340 350 360 MAKGLPVRNA VNLPSIEPSD FEFMMPFLTL AEKMGKIASV RLGGAIRKVK VTCSGKLATK 370 380 390 400 410 420 NTEFVTRALL KGLFEPILSN EINLVSAKPV AVERGITIEE SKVESVEHYE SLLEVWVESN 430 440 450 460 470 480 GKEMYLAGTC FGNEYRILKI DVYNVNFVPK GHYIISLHED KPGVIGRVGT LFGRNNINIA 490 500 510 520 GMIVGRSGDK PGGIQLMLLL VDDPPTPEVL EEMTKLDGII DATYVEL

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000782 Genomic DNA. Translation: AAB90429.1.
PIR	E69351.
RefSeq	NP_069647.1.
3D structure databases
HSSP	HSSP built from PDB template 1HL3 based on UniProtKB Q9Z2F5.
ModBase	Search...
Genome annotation databases
GeneID	1484032.
GenomeReviews	Gene locus AF_0813 in contig AE000782_GR.
KEGG	afu:AF0813.
NMPDR	fig|224325.1.peg.806.
TIGR	AF_0813.
Phylogenomic databases
HOGENOM	O29445.
OMA	O29445. KSFKGME.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0813-MON.
BRENDA	1.1.1.95. 7576.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR006236. D-3-Phosphoglycerate_DH. IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR015508. D3PG_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR10996:SF20. D3PG_Deh. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. PF01842. ACT. 1 hit. [Graphical view]
ProDom	PD002844. Acolac_synthsm. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01327. PGDH. 1 hit.
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00670. D_2_HYDROXYACID_DH_2. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SERA_ARCFU

Accession

Primary (citable) accession number: O29445

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)