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Protein

Trk system potassium uptake protein TrkA homolog

Gene

trkA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of a potassium transport system.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29NAD 1By similarity1
Binding sitei95NAD 1; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 11NAD 1By similarity5
Nucleotide bindingi71 – 72NAD 1By similarity2
Nucleotide bindingi226 – 253NAD 2Sequence analysisAdd BLAST28

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

NAD, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Trk system potassium uptake protein TrkA homolog
Short name:
K(+)-uptake protein TrkA homolog
Gene namesi
Name:trkA
Ordered Locus Names:AF_0838
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001487221 – 436Trk system potassium uptake protein TrkA homologAdd BLAST436

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0838.

Structurei

3D structure databases

ProteinModelPortaliO29420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 126RCK N-terminal 1PROSITE-ProRule annotationAdd BLAST125
Domaini138 – 219RCK C-terminal 1PROSITE-ProRule annotationAdd BLAST82
Domaini224 – 347RCK N-terminal 2PROSITE-ProRule annotationAdd BLAST124
Domaini356 – 436RCK C-terminal 2PROSITE-ProRule annotationAdd BLAST81

Domaini

The RCK N-terminal domain binds NAD and possibly other effectors. This is expected to cause a conformation change that regulates potassium transport (By similarity).By similarity

Sequence similaritiesi

Contains 2 RCK C-terminal domains.PROSITE-ProRule annotation
Contains 2 RCK N-terminal domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
KOiK03499.
OMAiLRHIRHG.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O29420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVIAGAGE VGYHLAMSLA PNHDVIIIEK DVSRFERVSE LDVVAINGNA
60 70 80 90 100
ANMKVLRDAG VERADVFLAV TGNDEVNLLS GLAAKKVGAK NVIVRVENPE
110 120 130 140 150
YVDRPIVKEH PLGYDVLICP QLSLAQEAAR LIGIPGAIEV VTFSGGKVEM
160 170 180 190 200
IELQVMEGSK ADGKAIADLY LPQNVVIASI YRNGHIEIPR GDTVLRAGDR
210 220 230 240 250
VAIVSKTEDV EMLKGIFGPP VTRRVTIFGA GTIGSYTAKI LAKGMTSVKL
260 270 280 290 300
IESSMERCEA LSGELEGVRI VCGDATDIEF LIEEEIGKSD AVLAATESDE
310 320 330 340 350
KNLLISLLSK NLGARIAIAK VEKREYVKLF EAVGVDVALN PRSVTYNEVS
360 370 380 390 400
KLLRTMRIET LAEIEGTAVV EVVVRNTRLV GKALKDLPLP KDAIIGAIVR
410 420 430
GNECLIPRGD TTIEYEDRLL VFAKWDEIEK IEEIFR
Length:436
Mass (Da):47,365
Last modified:January 1, 1998 - v1
Checksum:i5F5C0425BFA2B266
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90401.1.
PIRiF69354.
RefSeqiWP_010878341.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90401; AAB90401; AF_0838.
GeneIDi24794436.
KEGGiafu:AF_0838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90401.1.
PIRiF69354.
RefSeqiWP_010878341.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO29420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0838.

Protocols and materials databases

DNASUi1484057.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90401; AAB90401; AF_0838.
GeneIDi24794436.
KEGGiafu:AF_0838.

Phylogenomic databases

eggNOGiarCOG01957. Archaea.
COG0569. LUCA.
KOiK03499.
OMAiLRHIRHG.

Family and domain databases

Gene3Di3.30.70.1450. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR006036. K_uptake_TrkA.
IPR016040. NAD(P)-bd_dom.
IPR006037. RCK_C.
IPR003148. RCK_N.
[Graphical view]
PfamiPF02080. TrkA_C. 2 hits.
PF02254. TrkA_N. 2 hits.
[Graphical view]
PRINTSiPR00335. KUPTAKETRKA.
SUPFAMiSSF116726. SSF116726. 2 hits.
SSF51735. SSF51735. 2 hits.
PROSITEiPS51202. RCK_C. 2 hits.
PS51201. RCK_N. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRKA_ARCFU
AccessioniPrimary (citable) accession number: O29420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.