O29379 (ARLY_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	AF_0883

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137858

Sequences

	Sequence		Length	Mass (Da)
	O29379 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3F8E552CBAD5E161	FASTA	483	54,202
	10 20 30 40 50 60 MLRESRMKKG MDPKALKLSS SIEHDKNIFL YDILVDVAHV LTLKKGGYLS EEEAKEIILA 70 80 90 100 110 120 LKKVKDSGFR EDWPYEDVHE AIEAEVTKIT PHGAKMHTGR SRNDEVATCL RMFARDHLLN 130 140 150 160 170 180 LAEAILNALD VLIKKAEKSH FLMPGFTHLQ YAQPTRLSHH LLAYHDMLSR DFERAIEAFR 190 200 210 220 230 240 RVNKSPLGSA AFASTGYSLD RVYAARLLGF DGVVEHSEDA VASRDFVIES IFVAAEAMLS 250 260 270 280 290 300 ISRIAEEIVL FSSEFGFITL PDEFSSTSSI MPQKKNPDIA ELLRANAGKI AGNLTSAMMI 310 320 330 340 350 360 YKATPFSYNR DFQEMNPLLY ESLKRTHLAV EVFASMMGKI KFNPEITERK ASKGFATATE 370 380 390 400 410 420 LADMLVMKYG VPFRMAHRIV GRLAAKELER PTASDVNSAA KELGVEINVR DEDVLEALDV 430 440 450 460 470 480 EKVVENRGNL GGTSKAEVER MIKARKSDLK DRKTLLRKLR GEVKMGLKML YDEAKKLGVD INV

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90359.1.
PIR	C69360.
RefSeq	NP_069716.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29379.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1484105.
GenomeReviews	Gene locus AF_0883 in contig AE000782_GR.
KEGG	afu:AF0883.
NMPDR	fig|224325.1.peg.875.
TIGR	AF_0883.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
PhylomeDB	O29379.
ProtClustDB	CLSK2746644.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0883-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ARCFU

Accession

Primary (citable) accession number: O29379

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program