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Protein

Argininosuccinate lyase

Gene

argH

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:AF_0883
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001378581 – 483Argininosuccinate lyaseAdd BLAST483

Proteomic databases

PRIDEiO29379.

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0883.

Structurei

3D structure databases

ProteinModelPortaliO29379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
KOiK01755.
OMAiPANAVND.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.

Sequencei

Sequence statusi: Complete.

O29379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRESRMKKG MDPKALKLSS SIEHDKNIFL YDILVDVAHV LTLKKGGYLS
60 70 80 90 100
EEEAKEIILA LKKVKDSGFR EDWPYEDVHE AIEAEVTKIT PHGAKMHTGR
110 120 130 140 150
SRNDEVATCL RMFARDHLLN LAEAILNALD VLIKKAEKSH FLMPGFTHLQ
160 170 180 190 200
YAQPTRLSHH LLAYHDMLSR DFERAIEAFR RVNKSPLGSA AFASTGYSLD
210 220 230 240 250
RVYAARLLGF DGVVEHSEDA VASRDFVIES IFVAAEAMLS ISRIAEEIVL
260 270 280 290 300
FSSEFGFITL PDEFSSTSSI MPQKKNPDIA ELLRANAGKI AGNLTSAMMI
310 320 330 340 350
YKATPFSYNR DFQEMNPLLY ESLKRTHLAV EVFASMMGKI KFNPEITERK
360 370 380 390 400
ASKGFATATE LADMLVMKYG VPFRMAHRIV GRLAAKELER PTASDVNSAA
410 420 430 440 450
KELGVEINVR DEDVLEALDV EKVVENRGNL GGTSKAEVER MIKARKSDLK
460 470 480
DRKTLLRKLR GEVKMGLKML YDEAKKLGVD INV
Length:483
Mass (Da):54,202
Last modified:January 1, 1998 - v1
Checksum:i3F8E552CBAD5E161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90359.1.
PIRiC69360.
RefSeqiWP_010878383.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB90359; AAB90359; AF_0883.
GeneIDi24794484.
KEGGiafu:AF_0883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB90359.1.
PIRiC69360.
RefSeqiWP_010878383.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO29379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF0883.

Proteomic databases

PRIDEiO29379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB90359; AAB90359; AF_0883.
GeneIDi24794484.
KEGGiafu:AF_0883.

Phylogenomic databases

eggNOGiarCOG01748. Archaea.
COG0165. LUCA.
KOiK01755.
OMAiPANAVND.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARLY_ARCFU
AccessioniPrimary (citable) accession number: O29379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.