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O29368 (SYR_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:AF_0894
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151643

Regions

Motif113 – 12311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
O29368 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 39DF41CC0B9AD210

FASTA54962,862
        10         20         30         40         50         60 
MFLRFIEEVI KALGEYGDKK FLRESEHADL ASTIAFKLAK ERKKSPKEIA DEIVENLEVE 

        70         80         90        100        110        120 
SEYIGSVESV NGYINFFASY EFLEDTVNVI LDEDENYGHL NLKGEILIEH TSANPDGPLH 

       130        140        150        160        170        180 
IGHIRNSIIG DTIARIFAKA GFDVKTHYYV NDMGRQTAIT VLGIEKFGLK DKKPDHAVAE 

       190        200        210        220        230        240 
AYIEANKLLE SNPELEEQVE KLMLAYEEGD EKTVEKFRRA VETALEGIKQ TLKTINVEHD 

       250        260        270        280        290        300 
EFVWESEFVR NGYVGKVLGI LEERGLVKKN GAWTIELEGF DKEVVLRREN GTTLYITRDL 

       310        320        330        340        350        360 
AYHMWKNENY ERFINVLGAD HKLYGAQLSK ILELLGLKPP EIIFFEFVSL PEGSMSTRRG 

       370        380        390        400        410        420 
KFISADELIS KVRDEAWKIL SERDMEEDEK RKIADAVAVG AIRFDFIKIA PEKHMTFDWS 

       430        440        450        460        470        480 
KALDFERQTA SYIQYSHARA CSILRKAVED GMPELEFKGE LCTAGERKLV MLLSKMPYVV 

       490        500        510        520        530        540 
KRIVSELRPN VFAEYLLSVA GTFNDFYRDH PVLKAESEVR MHRLAIVDAT RVVLRNGLEL 


LGIEPLERM 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90346.1.
PIRF69361.
RefSeqNP_069727.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29368.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF0894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90346; AAB90346; AF_0894.
GeneID1484117.
KEGGafu:AF0894.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAELGDMQA.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-916-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_ARCFU
AccessionPrimary (citable) accession number: O29368
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries