O29368 (SYR_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	AF_0894

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000151643
Regions
	Motif	113 – 123	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	O29368 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 39DF41CC0B9AD210	FASTA	549	62,862
	10 20 30 40 50 60 MFLRFIEEVI KALGEYGDKK FLRESEHADL ASTIAFKLAK ERKKSPKEIA DEIVENLEVE 70 80 90 100 110 120 SEYIGSVESV NGYINFFASY EFLEDTVNVI LDEDENYGHL NLKGEILIEH TSANPDGPLH 130 140 150 160 170 180 IGHIRNSIIG DTIARIFAKA GFDVKTHYYV NDMGRQTAIT VLGIEKFGLK DKKPDHAVAE 190 200 210 220 230 240 AYIEANKLLE SNPELEEQVE KLMLAYEEGD EKTVEKFRRA VETALEGIKQ TLKTINVEHD 250 260 270 280 290 300 EFVWESEFVR NGYVGKVLGI LEERGLVKKN GAWTIELEGF DKEVVLRREN GTTLYITRDL 310 320 330 340 350 360 AYHMWKNENY ERFINVLGAD HKLYGAQLSK ILELLGLKPP EIIFFEFVSL PEGSMSTRRG 370 380 390 400 410 420 KFISADELIS KVRDEAWKIL SERDMEEDEK RKIADAVAVG AIRFDFIKIA PEKHMTFDWS 430 440 450 460 470 480 KALDFERQTA SYIQYSHARA CSILRKAVED GMPELEFKGE LCTAGERKLV MLLSKMPYVV 490 500 510 520 530 540 KRIVSELRPN VFAEYLLSVA GTFNDFYRDH PVLKAESEVR MHRLAIVDAT RVVLRNGLEL LGIEPLERM

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB90346.1.
PIR	F69361.
RefSeq	NP_069727.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O29368.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1484117.
GenomeReviews	Gene locus AF_0894 in contig AE000782_GR.
KEGG	afu:AF0894.
NMPDR	fig|224325.1.peg.886.
TIGR	AF_0894.
Phylogenomic databases
HOGENOM	HBG695395.
OMA	NPNGPLH.
PhylomeDB	O29368.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_0894-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ARCFU

Accession

Primary (citable) accession number: O29368

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program