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O29353 (DAPB_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26
Gene names
Name:dapB
Ordered Locus Names:AF_0909
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102

Subcellular location

Cytoplasm By similarity HAMAP MF_00102.

Sequence similarities

Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADPH binding

Inferred from electronic annotation. Source: InterPro

dihydrodipicolinate reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Dihydrodipicolinate reductase HAMAP MF_00102
PRO_0000141515

Sequences

Sequence LengthMass (Da)Tools
O29353 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 4798A97AFB6097A8

FASTA25728,096
        10         20         30         40         50         60 
MRVAVSGAAG RMGRLVVKNA VAEGLKVVQA FDINEVGKDA GELAGVGKIG VPIEDDISKL 

        70         80         90        100        110        120 
DADVLIDFTT AEAAMKNAEV AAEKGVRVVM GTTGFTDEDR KRLAELAEKV PMIVSPNFSL 

       130        140        150        160        170        180 
GVNIFWKIVE YAAKMLYEWD AEIVELHHRH KRDSPSGTAL KLAEIIRKVK EEKGIEADLK 

       190        200        210        220        230        240 
TCREGISPRE SEIGVFGIRG GDVVGEHTVF FFGSGERIEL THRAMSRECF AIGAVRAAKW 

       250 
IAKVDKPGFY TMDDFLE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB90331.1.
PIRE69363.
RefSeqNP_069742.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29353.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1484132.
GenomeReviewsGene locus AF_0909 in contig AE000782_GR.
KEGGafu:AF0909.
NMPDRfig|224325.1.peg.901.
TIGRAF_0909.

Phylogenomic databases

HOGENOMHBG594002.
OMADEIGIHA.
PhylomeDBO29353.
ProtClustDBCLSK2746656.

Enzyme and pathway databases

BioCycAFUL224325:AF_0909-MONOMER.

Family and domain databases

HAMAPMF_00102. DapB.
[Tree]
InterProIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00215.
PANTHERPTHR20836. DapB_bac/pln. 1 hit.
PfamPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFPIRSF000161. DHPR. 1 hit.
TIGRFAMsTIGR00036. DapB. 1 hit.
PROSITEPS01298. DAPB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_ARCFU
AccessionPrimary (citable) accession number: O29353
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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