Skip Header

Contribute Send feedback
Read comments (?) or add your own

O29352 (DAPA_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:AF_0910
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103193

Regions

Region47 – 482Pyruvate binding By similarity

Sites

Active site1581Schiff-base intermediate with substrate By similarity
Binding site1031Pyruvate By similarity
Site1301Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
O29352 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 63E045542EA1FFB3

FASTA28931,692
        10         20         30         40         50         60 
MFEGVIPAMV TPFKEDFSVD YEGIAKNLDY LEKHVNALVP AGTTGEAATL SYEEHIDVVR 

        70         80         90        100        110        120 
YVAETSKLPV IGGAGSNSTR EAIWLAKEVE KAGAEAAMLV TPYYNKPNAE GLYQHYKAVA 

       130        140        150        160        170        180 
SEVSIPIIVY NVPSRTGINT TPELVRRLAE IDNIFGIKEA SGNLKQISEI IRTTPDDFVL 

       190        200        210        220        230        240 
LSGDDFLTLP ILCLGGKGVI SVAANVAPHL MKEMYEAFVE GNIERAREMH HRLTPLFDVL 

       250        260        270        280 
FIDTNPIPVK KALQLMGLAA GKPRLPLVEL SEEKTQKVKE VLKSLELIS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000782 Genomic DNA. Translation: AAB90330.1.
PIRF69363.
RefSeqNP_069743.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29352.
SMRO29352. Positions 1-288.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1484133.
GenomeReviewsGene locus AF_0910 in contig AE000782_GR.
KEGGafu:AF0910.
NMPDRfig|224325.1.peg.902.
TIGRAF_0910.

Phylogenomic databases

HOGENOMHBG358848.
OMAGIMACAN.
PhylomeDBO29352.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycAFUL224325:AF_0910-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_ARCFU
AccessionPrimary (citable) accession number: O29352
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: December 14, 2011
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents