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O29333 (PYRF_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:AF_0929
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Sequence caution

The sequence AAB90309.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000134608

Regions

Region57 – 6610Substrate binding By similarity
Region166 – 17611Substrate binding By similarity

Sites

Active site591Proton donor By similarity
Binding site91Substrate By similarity
Binding site311Substrate By similarity
Binding site1141Substrate By similarity
Binding site1871Substrate; via amide nitrogen By similarity
Binding site1881Substrate By similarity

Secondary structure

.......................................... 209
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O29333 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: C6CBB39E9C105B66

FASTA20922,538
        10         20         30         40         50         60 
MKQLILALDV MDGEKAMEIA KKVAEHVDRI KVNYPLVLSA GVGIMKRLSE IKPVIADFKI 

        70         80         90        100        110        120 
ADVPYTSSLI ARIAFENSAE SVIVHGFVGS DTLREVCRVA EEFGGKVYAV TELSSPGGEE 

       130        140        150        160        170        180 
FMSAVSLKIV EKAKEAGCHG LIAPSTRIER LREIRKAAGD MEILCPGIGA QKGSIEAVKY 

       190        200 
ADGIIVGRGI YASGNPAEEA RKLRRVLKI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90309.1. Different initiation.
PIRA69366.
RefSeqNP_069762.1. NC_000917.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4MUZX-ray1.39A/B1-209[»]
4N2YX-ray1.55A/B/C/D1-209[»]
ProteinModelPortalO29333.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF0929.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90309; AAB90309; AF_0929.
GeneID1484152.
KEGGafu:AF0929.

Phylogenomic databases

eggNOGCOG0284.
KOK01591.
OMARIAFENS.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-951-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_A. OMPdecase_type1_A.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_ARCFU
AccessionPrimary (citable) accession number: O29333
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2002
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways