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Protein

Elongation factor 1-alpha

Gene

tuf

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPUniRule annotation8
Nucleotide bindingi91 – 95GTPUniRule annotation5
Nucleotide bindingi146 – 149GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFUL224325:G1G17-966-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alphaUniRule annotation
Short name:
EF-1-alphaUniRule annotation
Alternative name(s):
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:AF_0937
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000909751 – 423Elongation factor 1-alphaAdd BLAST423

Proteomic databases

PRIDEiO29325

Interactioni

Protein-protein interaction databases

STRINGi224325.AF0937

Structurei

3D structure databases

ProteinModelPortaliO29325
SMRiO29325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 221tr-type GAdd BLAST217

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni146 – 149G4By similarity4
Regioni185 – 187G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01561 Archaea
COG5256 LUCA
KOiK03231
OMAiAIRDMGM
OrthoDBiPOG093Z025H

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O29325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKEHINV AFIGHVDHGK STLIGRLLYE TGEIPEHIIE KMRKEAQEKG
60 70 80 90 100
KATFEFAWVM DRLKEERERG VTIDVAHRKF QTDKYYITIV DCPGHRDFIK
110 120 130 140 150
NMITGASQAD AAVLVMDVVE KVQPQTREHI FLARTLGINQ IIVAINKMDR
160 170 180 190 200
VNYDQKEYEA AKEAVSKLLK MVGYKVDEIP FIPVSAYYGD NVAKKSDKTP
210 220 230 240 250
WYNGPTLLEA FDLLKPPEKL VDKPLRIPIQ DVYSISGVGT VPVGRVESGV
260 270 280 290 300
LRVGDKVVFE PAGVSGEVKS IEMHHEPIQE AYPGDNIGFN VRGVSKKDIR
310 320 330 340 350
RGDVAGHPDN PPTVVKDFTA QLVVLQHPTA ITVGYTPVVH AHTAQIACRF
360 370 380 390 400
VELQKKIDPR TGQVKEENPQ FLKTGDAAIV KLEPTRPMVI ERVKDIPPMG
410 420
RFAIRDMGMT IGAGMVLDLT PRK
Length:423
Mass (Da):47,301
Last modified:January 1, 1998 - v1
Checksum:i1CE0870153315D27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB90301.1
PIRiA69367
RefSeqiWP_010878437.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB90301; AAB90301; AF_0937
GeneIDi1484160
KEGGiafu:AF_0937

Similar proteinsi

Entry informationi

Entry nameiEF1A_ARCFU
AccessioniPrimary (citable) accession number: O29325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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