Reviewed, UniProtKB/Swiss-Prot O29157 (DUT_ARCFU)

Names and origin

Protein names

Recommended name:
    Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
      Short name=dUTPase
    EC=3.6.1.23
Alternative name(s):
    dUTP pyrophosphatase

Gene names

Name:	dut
Ordered Locus Names:	AF_1108

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00635
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00635
Sequence similarities	Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Probable deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00635		PRO_0000153635

Sequences

	Sequence		Length	Mass (Da)
	O29157-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D99EE0FB943869D6	FASTA	168	19,227
	10 20 30 40 50 60 MAVLSGDEIR KLIQKEGLIR DYVDLETQIQ PNGFDCTLRS VYRLRGCGRV DFDNSRRELP 70 80 90 100 110 120 ELEEVEFRDW VYLPKGVYRA KLNEVVRLGN DIMAIARPRS TLIRCGANVL TAVWDAGYEG 130 140 150 160 RSEVSIVVHN DYGIWLSRNA RIIQLVFIRL SSPTKGYEGV YKGENIDS

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000782 Genomic DNA. Translation: AAB90130.1.
PIR	C69388.
RefSeq	NP_069937.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1484330.
GenomeReviews	Gene locus AF_1108 in contig AE000782_GR.
KEGG	afu:AF1108.
NMPDR	fig|224325.1.peg.1096.
TIGR	AF_1108.
Phylogenomic databases
HOGENOM	O29157.
OMA	TAVWDAG.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_1108-MON.
BRENDA	3.6.1.23. 7576.
Family and domain databases
HAMAP	MF_00635. [Tree]
ProDom	PD004900. dCTP_deaminase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

DUT_ARCFU

Accession

Primary (citable) accession number: O29157

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)