Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O29157 (DUT_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:dut
Ordered Locus Names:AF_1108
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP-Rule MF_00635

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP-Rule MF_00635

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00635

Sequence similarities

Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168Probable deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00635
PRO_0000153635

Sequences

Sequence LengthMass (Da)Tools
O29157 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: D99EE0FB943869D6

FASTA16819,227
        10         20         30         40         50         60 
MAVLSGDEIR KLIQKEGLIR DYVDLETQIQ PNGFDCTLRS VYRLRGCGRV DFDNSRRELP 

        70         80         90        100        110        120 
ELEEVEFRDW VYLPKGVYRA KLNEVVRLGN DIMAIARPRS TLIRCGANVL TAVWDAGYEG 

       130        140        150        160 
RSEVSIVVHN DYGIWLSRNA RIIQLVFIRL SSPTKGYEGV YKGENIDS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90130.1.
PIRC69388.
RefSeqNP_069937.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1108.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90130; AAB90130; AF_1108.
GeneID1484330.
KEGGafu:AF1108.

Phylogenomic databases

eggNOGCOG0717.
KOK01520.
OMAWDAGYEG.
ProtClustDBPRK02253.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1130-MONOMER.
UniPathwayUPA00610; UER00666.

Family and domain databases

HAMAPMF_00635. dUTPase_arch.
InterProIPR008180. dUTP_pyroPase.
IPR023537. dUTP_pyroPase_arch.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUT_ARCFU
AccessionPrimary (citable) accession number: O29157
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways