Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O29108 (PUR2_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:AF_1157
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Phosphoribosylamine--glycine ligase
PRO_0000151508

Regions

Domain115 – 354240ATP-grasp
Nucleotide binding142 – 20362ATP By similarity

Sites

Metal binding3241Magnesium or manganese By similarity
Metal binding3261Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
O29108 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C3B90CED22DCD353

FASTA47051,750
        10         20         30         40         50         60 
MKVLVVDAGG RGNAIAHAFS RSEQVKEIYI APGNGGSEFF EKCKIAELDG KKIPSIRAID 

        70         80         90        100        110        120 
EIVRFAKKCE VDLAYIGPEE PLSLGLVDRL EEEGIPAVGP KKEATILEAS KCWAKDFLKR 

       130        140        150        160        170        180 
IGVPIPEYAN FDNPEEAKEY IREKFNNGIV VKADGLAAGK GVYVCDSVEE ALRAVDEIMV 

       190        200        210        220        230        240 
QKKFGEAGNR IVVEERLRGI EVAFTAMTDG KTVKPFGHAR DYKRAFDSDD IEGLRDFYIG 

       250        260        270        280        290        300 
LTKKFYTKAQ IEQLYREGKL INPNTGGMGA VSPHPAVTEE VEQRIMEMVV EPIIENFDKE 

       310        320        330        340        350        360 
FKGVLYPVIM LVEENGELIP KVLEINVRDC DPGAEAKLPR LKSDMAEISM AVVEGRLDEV 

       370        380        390        400        410        420 
EMRFSSDYCV AVCAVSGALK GREGLKPGYP ADHYTSQPIT GIEEAMKEAI IYANGIAKTN 

       430        440        450        460        470 
GYVTTGGRVL TVVGMGQSIE EARSKAYSAL EKISFPGMRY RRTIGLDVPE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB90089.1.
PIRD69394.
RefSeqNP_069986.1. NC_000917.1.

3D structure databases

ProteinModelPortalO29108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1157.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB90089; AAB90089; AF_1157.
GeneID1484381.
KEGGafu:AF1157.

Phylogenomic databases

eggNOGCOG0151.
KOK01945.
OMADPEAMNV.
ProtClustDBCLSK541657.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1182-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_ARCFU
AccessionPrimary (citable) accession number: O29108
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways