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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78Carbamoyl phosphateUniRule annotation1
Binding sitei102Carbamoyl phosphateUniRule annotation1
Binding sitei160OrnithineUniRule annotation1
Binding sitei220OrnithineUniRule annotation1
Binding sitei288Carbamoyl phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:AF_1255
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130621 – 307Ornithine carbamoyltransferaseAdd BLAST307

Proteomic databases

PRIDEiO29013

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1255

Structurei

3D structure databases

ProteinModelPortaliO29013
SMRiO29013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 54Carbamoyl phosphate bindingUniRule annotation4
Regioni129 – 132Carbamoyl phosphate bindingUniRule annotation4
Regioni224 – 225Ornithine bindingUniRule annotation2
Regioni260 – 261Carbamoyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912 Archaea
COG0078 LUCA
KOiK00611
OMAiDGNNVCN
OrthoDBiPOG093Z05BF

Family and domain databases

Gene3Di3.40.50.1370, 2 hits
HAMAPiMF_01109 OTCase, 1 hit
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR002292 Orn/put_carbamltrans
IPR024904 OTCase_ArgI
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00102 OTCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR00658 orni_carb_tr, 1 hit

Sequencei

Sequence statusi: Complete.

O29013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLLSMADL EKDELFEILK LAEKLKEERY KGVVTDYLKN KSLAMIFELP
60 70 80 90 100
STRTRVSFEV AMTDLGGHAL YLGWDELQLG RGEPIKDTAR VLSRYVHAVM
110 120 130 140 150
MRVREHSTIE EFARYSTVPV INGLSNLEHP CQVIADLLTI YEYRGDFKDV
160 170 180 190 200
TLAWVGDGNN VCNSMILAAA LTGMKMVIST PENYDPNPEI VKKAEEMGAK
210 220 230 240 250
LRFVRDPKEA VKEADVIYTD VWTSMGQEAE KEARLKAFQP YQVSDELLKF
260 270 280 290 300
SKDDVVVMHC LPAHRGEEIT DEVMEGKHSI VFDQAENRLH AQKAILLKLL

GKESEVY
Length:307
Mass (Da):34,913
Last modified:January 1, 1998 - v1
Checksum:iDB043BC5A40EBB5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89987.1
PIRiF69406
RefSeqiWP_010878750.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89987; AAB89987; AF_1255
GeneIDi24794858
KEGGiafu:AF_1255

Similar proteinsi

Entry informationi

Entry nameiOTC_ARCFU
AccessioniPrimary (citable) accession number: O29013
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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