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Protein

Ornithine carbamoyltransferase

Gene

argF

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.By similarity

Catalytic activityi

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ornithine carbamoyltransferase (argF)
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei5Carbamoyl phosphateBy similarity1
Binding sitei78Carbamoyl phosphateBy similarity1
Binding sitei102Carbamoyl phosphateBy similarity1
Binding sitei160OrnithineBy similarity1
Binding sitei220OrnithineBy similarity1
Binding sitei270Carbamoyl phosphateBy similarity1
Binding sitei288Carbamoyl phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine carbamoyltransferase (EC:2.1.3.3)
Short name:
OTCase
Gene namesi
Name:argF
Ordered Locus Names:AF_1255
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001130621 – 307Ornithine carbamoyltransferaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1255.

Structurei

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei26Important for structural integrityBy similarity1
Sitei142Important for structural integrityBy similarity1

3D structure databases

ProteinModelPortaliO29013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 55Carbamoyl phosphate bindingBy similarity5
Regioni129 – 132Carbamoyl phosphate bindingBy similarity4
Regioni224 – 225Ornithine bindingBy similarity2
Regioni259 – 262Carbamoyl phosphate bindingBy similarity4

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiarCOG00912. Archaea.
COG0078. LUCA.
KOiK00611.
OMAiEHPCQIL.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.

Sequencei

Sequence statusi: Complete.

O29013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLLSMADL EKDELFEILK LAEKLKEERY KGVVTDYLKN KSLAMIFELP
60 70 80 90 100
STRTRVSFEV AMTDLGGHAL YLGWDELQLG RGEPIKDTAR VLSRYVHAVM
110 120 130 140 150
MRVREHSTIE EFARYSTVPV INGLSNLEHP CQVIADLLTI YEYRGDFKDV
160 170 180 190 200
TLAWVGDGNN VCNSMILAAA LTGMKMVIST PENYDPNPEI VKKAEEMGAK
210 220 230 240 250
LRFVRDPKEA VKEADVIYTD VWTSMGQEAE KEARLKAFQP YQVSDELLKF
260 270 280 290 300
SKDDVVVMHC LPAHRGEEIT DEVMEGKHSI VFDQAENRLH AQKAILLKLL

GKESEVY
Length:307
Mass (Da):34,913
Last modified:January 1, 1998 - v1
Checksum:iDB043BC5A40EBB5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89987.1.
PIRiF69406.
RefSeqiWP_010878750.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89987; AAB89987; AF_1255.
GeneIDi24794858.
KEGGiafu:AF_1255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89987.1.
PIRiF69406.
RefSeqiWP_010878750.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO29013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89987; AAB89987; AF_1255.
GeneIDi24794858.
KEGGiafu:AF_1255.

Phylogenomic databases

eggNOGiarCOG00912. Archaea.
COG0078. LUCA.
KOiK00611.
OMAiEHPCQIL.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00112.

Family and domain databases

Gene3Di3.40.50.1370. 2 hits.
HAMAPiMF_01109. OTCase. 1 hit.
InterProiIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. OTCase_ArgI.
[Graphical view]
PfamiPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSiPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMiSSF53671. SSF53671. 1 hit.
TIGRFAMsiTIGR00658. orni_carb_tr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOTC_ARCFU
AccessioniPrimary (citable) accession number: O29013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.