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Protein

GMP synthase [glutamine-hydrolyzing] subunit A

Gene

guaAA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.UniRule annotation

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.UniRule annotation

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] subunit A (guaAA), GMP synthase [glutamine-hydrolyzing] subunit B (guaAB)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74NucleophileUniRule annotation1
Active sitei161UniRule annotation1
Active sitei163UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.A31.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit AUniRule annotation (EC:6.3.5.2UniRule annotation)
Alternative name(s):
Glutamine amidotransferaseUniRule annotation
Gene namesi
Name:guaAAUniRule annotation
Ordered Locus Names:AF_1320
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001402171 – 183GMP synthase [glutamine-hydrolyzing] subunit AAdd BLAST183

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF1320.

Structurei

3D structure databases

ProteinModelPortaliO28949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 183Glutamine amidotransferase type-1UniRule annotationAdd BLAST182

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-1 domain.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiarCOG00087. Archaea.
COG0518. LUCA.
KOiK01951.
OMAiGGPDMDR.

Family and domain databases

CDDicd01742. GATase1_GMP_Synthase. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_GATase.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O28949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIYVIYNYG QYNHLIHRTL RDLGVETKLV ENTTPVEQLK DVDGLVIGGG
60 70 80 90 100
PSLDRTGNCE LYLKELDVPM IGICLGHQLM AKVFGGEVGK GSMGGYSEVK
110 120 130 140 150
VRIVEDDELF EGIPREITVW ASHMDEVKKL PEGFKRLAES DICKIEAMRH
160 170 180
EKKPLYGVQW HPEVYHSQFG VELYRNFIEI CKK
Length:183
Mass (Da):20,884
Last modified:January 1, 1998 - v1
Checksum:iBA11A3E31ABF6C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89925.1.
PIRiG69414.
RefSeqiWP_010878817.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89925; AAB89925; AF_1320.
GeneIDi24794932.
KEGGiafu:AF_1320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89925.1.
PIRiG69414.
RefSeqiWP_010878817.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO28949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1320.

Protein family/group databases

MEROPSiC26.A31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89925; AAB89925; AF_1320.
GeneIDi24794932.
KEGGiafu:AF_1320.

Phylogenomic databases

eggNOGiarCOG00087. Archaea.
COG0518. LUCA.
KOiK01951.
OMAiGGPDMDR.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Family and domain databases

CDDicd01742. GATase1_GMP_Synthase. 1 hit.
Gene3Di3.40.50.880. 1 hit.
HAMAPiMF_01510. GMP_synthase_A. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR004739. GMP_synth_GATase.
IPR023686. GMP_synthase_A.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAAA_ARCFU
AccessioniPrimary (citable) accession number: O28949
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.