O28928 (TYPH1_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase 1
EC=2.4.2.4

Alternative name(s):
TdRPase 1

Gene names

Ordered Locus Names:

AF_1341

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	molybdenum ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Putative thymidine phosphorylase 1 HAMAP-Rule MF_00703		PRO_0000059085

Sequences

	Sequence		Length	Mass (Da)
	O28928 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A10C382B81E22FA6	FASTA	504	54,098
	10 20 30 40 50 60 MIFKAVRVPF KSGRFAVILN EEDASELGVR EGDRVRVRYG KAGVVATVQI TREIVEKGFV 70 80 90 100 110 120 GLTDLASMEL GISDGAEVDV FPSPKPKSVE LIKKKTRGEK LSQDEIRRIV EDITNNALSE 130 140 150 160 170 180 VELTAFVISS MLRGMDFDEI EWLTRSMIET GERIEFDRGT VVDKHSIGGV PGNKISLLIV 190 200 210 220 230 240 PTVAAAGLLI PKTASRAITS ASGTADTMEV LANVNLSVDE IKEITERVGG VIAWGGATNI 250 260 270 280 290 300 APADDKIIRV EHPLSIDPRP QLLASVMAKK GSVGAKHVVI DIPVGEGAKI EKVEVGRSLA 310 320 330 340 350 360 NDFIELGRRL GLNVMAAITY GGQPVGRAIG PALEAREALK TMEDRRGPSS LVEKSLGIAG 370 380 390 400 410 420 ILFEMTGIAT NGYQHARKIF ESGKTLEKFR EIVAAQGGDE SVKAEDVAVG DKTYTLTSQV 430 440 450 460 470 480 EGAVVSVNNK SIVKIARTAG APKDKGAGVY VHKKRGEVVK VGDPLLTIYA EKEWKLDNAI 490 500 EVANTERPIV VSGMVLEVYG RRGV

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB89903.1.
PIR	D69417.
RefSeq	NP_070170.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O28928.
ModBase	Search...
Protein-protein interaction databases
STRING	224325.AF1341.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB89903; AAB89903; AF_1341.
GeneID	1484567.
KEGG	afu:AF1341.
Phylogenomic databases
eggNOG	COG0213.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	AFUL224325:GJBC-1371-MONOMER.
Family and domain databases
Gene3D	2.40.40.20. 1 hit. 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR009010. Asp_de-COase-like_dom. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR006657. MoPterin_dinucl-bd_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF01568. Molydop_binding. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH1_ARCFU

Accession

Primary (citable) accession number: O28928

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program