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Protein

AMP phosphorylase 1

Gene

AF_1341

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Active sitei257Proton donorUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase 1UniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpase 1UniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylase 1UniRule annotation
Short name:
NMP phosphorylase 1UniRule annotation
Gene namesi
Ordered Locus Names:AF_1341
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590851 – 504AMP phosphorylase 1Add BLAST504

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1341

Structurei

3D structure databases

ProteinModelPortaliO28928
SMRiO28928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR009010 Asp_de-COase-like_dom_sf
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR006657 MoPterin_dinucl-bd_dom
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF01568 Molydop_binding, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF50692 SSF50692, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

O28928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFKAVRVPF KSGRFAVILN EEDASELGVR EGDRVRVRYG KAGVVATVQI
60 70 80 90 100
TREIVEKGFV GLTDLASMEL GISDGAEVDV FPSPKPKSVE LIKKKTRGEK
110 120 130 140 150
LSQDEIRRIV EDITNNALSE VELTAFVISS MLRGMDFDEI EWLTRSMIET
160 170 180 190 200
GERIEFDRGT VVDKHSIGGV PGNKISLLIV PTVAAAGLLI PKTASRAITS
210 220 230 240 250
ASGTADTMEV LANVNLSVDE IKEITERVGG VIAWGGATNI APADDKIIRV
260 270 280 290 300
EHPLSIDPRP QLLASVMAKK GSVGAKHVVI DIPVGEGAKI EKVEVGRSLA
310 320 330 340 350
NDFIELGRRL GLNVMAAITY GGQPVGRAIG PALEAREALK TMEDRRGPSS
360 370 380 390 400
LVEKSLGIAG ILFEMTGIAT NGYQHARKIF ESGKTLEKFR EIVAAQGGDE
410 420 430 440 450
SVKAEDVAVG DKTYTLTSQV EGAVVSVNNK SIVKIARTAG APKDKGAGVY
460 470 480 490 500
VHKKRGEVVK VGDPLLTIYA EKEWKLDNAI EVANTERPIV VSGMVLEVYG

RRGV
Length:504
Mass (Da):54,098
Last modified:January 1, 1998 - v1
Checksum:iA10C382B81E22FA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89903.1
PIRiD69417
RefSeqiWP_010878838.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89903; AAB89903; AF_1341
GeneIDi24794953
KEGGiafu:AF_1341

Similar proteinsi

Entry informationi

Entry nameiAMPP1_ARCFU
AccessioniPrimary (citable) accession number: O28928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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