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O28928

- AMPP1_ARCFU

UniProt

O28928 - AMPP1_ARCFU

Protein

AMP phosphorylase 1

Gene

AF_1341

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei169 – 1691AMP; via amide nitrogenUniRule annotation
    Binding sitei204 – 2041AMP; via amide nitrogenUniRule annotation
    Active sitei257 – 2571Proton donorUniRule annotation
    Binding sitei265 – 2651AMPUniRule annotation
    Binding sitei289 – 2891AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi195 – 2006AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. molybdenum ion binding Source: InterPro
    3. oxidoreductase activity Source: InterPro
    4. phosphorylase activity Source: InterPro
    5. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciAFUL224325:GJBC-1371-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylase 1UniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpase 1UniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylase 1UniRule annotation
    Short name:
    NMP phosphorylase 1UniRule annotation
    Gene namesi
    Ordered Locus Names:AF_1341
    OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
    Taxonomic identifieri224325 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
    ProteomesiUP000002199: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504AMP phosphorylase 1PRO_0000059085Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224325.AF1341.

    Structurei

    3D structure databases

    ProteinModelPortaliO28928.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    KOiK00758.
    OMAiLEWAFDE.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR009010. Asp_de-COase-like_dom.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF50692. SSF50692. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O28928-1 [UniParc]FASTAAdd to Basket

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    MIFKAVRVPF KSGRFAVILN EEDASELGVR EGDRVRVRYG KAGVVATVQI    50
    TREIVEKGFV GLTDLASMEL GISDGAEVDV FPSPKPKSVE LIKKKTRGEK 100
    LSQDEIRRIV EDITNNALSE VELTAFVISS MLRGMDFDEI EWLTRSMIET 150
    GERIEFDRGT VVDKHSIGGV PGNKISLLIV PTVAAAGLLI PKTASRAITS 200
    ASGTADTMEV LANVNLSVDE IKEITERVGG VIAWGGATNI APADDKIIRV 250
    EHPLSIDPRP QLLASVMAKK GSVGAKHVVI DIPVGEGAKI EKVEVGRSLA 300
    NDFIELGRRL GLNVMAAITY GGQPVGRAIG PALEAREALK TMEDRRGPSS 350
    LVEKSLGIAG ILFEMTGIAT NGYQHARKIF ESGKTLEKFR EIVAAQGGDE 400
    SVKAEDVAVG DKTYTLTSQV EGAVVSVNNK SIVKIARTAG APKDKGAGVY 450
    VHKKRGEVVK VGDPLLTIYA EKEWKLDNAI EVANTERPIV VSGMVLEVYG 500
    RRGV 504
    Length:504
    Mass (Da):54,098
    Last modified:January 1, 1998 - v1
    Checksum:iA10C382B81E22FA6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB89903.1.
    PIRiD69417.
    RefSeqiNP_070170.1. NC_000917.1.

    Genome annotation databases

    EnsemblBacteriaiAAB89903; AAB89903; AF_1341.
    GeneIDi1484567.
    KEGGiafu:AF1341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000782 Genomic DNA. Translation: AAB89903.1 .
    PIRi D69417.
    RefSeqi NP_070170.1. NC_000917.1.

    3D structure databases

    ProteinModelPortali O28928.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224325.AF1341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB89903 ; AAB89903 ; AF_1341 .
    GeneIDi 1484567.
    KEGGi afu:AF1341.

    Phylogenomic databases

    eggNOGi COG0213.
    KOi K00758.
    OMAi LEWAFDE.

    Enzyme and pathway databases

    BioCyci AFUL224325:GJBC-1371-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR009010. Asp_de-COase-like_dom.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF50692. SSF50692. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
      Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
      , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
      Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

    Entry informationi

    Entry nameiAMPP1_ARCFU
    AccessioniPrimary (citable) accession number: O28928
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3