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O28928 (AMPP1_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
AMP phosphorylase 1

Short name=AMPpase 1
EC=2.4.2.-
Alternative name(s):
Nucleoside monophosphate phosphorylase 1
Short name=NMP phosphorylase 1
Gene names
Ordered Locus Names:AF_1341
OrganismArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]
Taxonomic identifier224325 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO By similarity. HAMAP-Rule MF_02132

Catalytic activity

AMP + phosphate = D-ribose 1,5-bisphosphate + adenine. HAMAP-Rule MF_02132

CMP + phosphate = D-ribose 1,5-bisphosphate + cytosine. HAMAP-Rule MF_02132

UMP + phosphate = D-ribose 1,5-bisphosphate + uracile. HAMAP-Rule MF_02132

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504AMP phosphorylase 1 HAMAP-Rule MF_02132
PRO_0000059085

Regions

Nucleotide binding195 – 2006AMP By similarity

Sites

Active site2571Proton donor By similarity
Binding site1691AMP; via amide nitrogen By similarity
Binding site2041AMP; via amide nitrogen By similarity
Binding site2651AMP By similarity
Binding site2891AMP By similarity

Sequences

Sequence LengthMass (Da)Tools
O28928 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: A10C382B81E22FA6

FASTA50454,098
        10         20         30         40         50         60 
MIFKAVRVPF KSGRFAVILN EEDASELGVR EGDRVRVRYG KAGVVATVQI TREIVEKGFV 

        70         80         90        100        110        120 
GLTDLASMEL GISDGAEVDV FPSPKPKSVE LIKKKTRGEK LSQDEIRRIV EDITNNALSE 

       130        140        150        160        170        180 
VELTAFVISS MLRGMDFDEI EWLTRSMIET GERIEFDRGT VVDKHSIGGV PGNKISLLIV 

       190        200        210        220        230        240 
PTVAAAGLLI PKTASRAITS ASGTADTMEV LANVNLSVDE IKEITERVGG VIAWGGATNI 

       250        260        270        280        290        300 
APADDKIIRV EHPLSIDPRP QLLASVMAKK GSVGAKHVVI DIPVGEGAKI EKVEVGRSLA 

       310        320        330        340        350        360 
NDFIELGRRL GLNVMAAITY GGQPVGRAIG PALEAREALK TMEDRRGPSS LVEKSLGIAG 

       370        380        390        400        410        420 
ILFEMTGIAT NGYQHARKIF ESGKTLEKFR EIVAAQGGDE SVKAEDVAVG DKTYTLTSQV 

       430        440        450        460        470        480 
EGAVVSVNNK SIVKIARTAG APKDKGAGVY VHKKRGEVVK VGDPLLTIYA EKEWKLDNAI 

       490        500 
EVANTERPIV VSGMVLEVYG RRGV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000782 Genomic DNA. Translation: AAB89903.1.
PIRD69417.
RefSeqNP_070170.1. NC_000917.1.

3D structure databases

ProteinModelPortalO28928.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224325.AF1341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAB89903; AAB89903; AF_1341.
GeneID1484567.
KEGGafu:AF1341.

Phylogenomic databases

eggNOGCOG0213.
KOK00758.
OMACHSEGFE.
ProtClustDBPRK04350.

Enzyme and pathway databases

BioCycAFUL224325:GJBC-1371-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_02132. AMP_phosphorylase.
InterProIPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR006657. MoPterin_dinucl-bd_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPP1_ARCFU
AccessionPrimary (citable) accession number: O28928
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families