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Protein

AMP phosphorylase 2

Gene

AF_1342

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei169AMP; via amide nitrogenUniRule annotation1
Binding sitei204AMP; via amide nitrogenUniRule annotation1
Binding sitei265AMPUniRule annotation1
Binding sitei289AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 200AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylase 2UniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpase 2UniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylase 2UniRule annotation
Short name:
NMP phosphorylase 2UniRule annotation
Gene namesi
Ordered Locus Names:AF_1342
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590861 – 505AMP phosphorylase 2Add BLAST505

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1342

Structurei

3D structure databases

ProteinModelPortaliO28927
SMRiO28927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
KOiK18931
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

O28927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFRIKTLPL RTERIAVVLS QDDAAELGLL PGDRVKVSYD GKSFVAEVEI
60 70 80 90 100
SQEFISSGEA GVCTFTAETC SLSEECVVEI VPFARPKSVE YIRKKLNGAK
110 120 130 140 150
YEREEIKDII GSISSDVLSD IEISAFILAN EIVGMQNDEI QWMIEAMVEV
160 170 180 190 200
GERVVFERGT VVDMHSIGGL PGNRFSLIAV PTVAAAGLLI PKTASRAITT
210 220 230 240 250
ASGTADTMEV LANVNLSVDE IKEITEEVGG VIAWNAPTGI APADEKIIRV
260 270 280 290 300
EYQLELSPKP HLMASVLSKK LGSGARFVAI DIPVGKKAKV ENVDVGRGFA
310 320 330 340 350
NAMMEIGRNL NLKVATALTD GSQPLGRAIG PALEAREVLE VMERKVEGDL
360 370 380 390 400
LEKSLGIAGI LFEMTGIATN GYQHARKIFE SGKTLEKFRE IVAAQGGDES
410 420 430 440 450
VKAEDVAVGD KTYTLHAAKE GYVREIDIAA LNEIARTAGA PKDKGAGVYV
460 470 480 490 500
HKKRGEVVKV GDPLLTIYAE KEWKLDNAIE VANTKQAFEI SGVIIERYTM

GRWWS
Length:505
Mass (Da):54,693
Last modified:January 1, 1998 - v1
Checksum:iA6FE00548E132F39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA Translation: AAB89902.1
PIRiE69417
RefSeqiWP_010878839.1, NC_000917.1

Genome annotation databases

EnsemblBacteriaiAAB89902; AAB89902; AF_1342
GeneIDi24794954
KEGGiafu:AF_1342

Similar proteinsi

Entry informationi

Entry nameiAMPP2_ARCFU
AccessioniPrimary (citable) accession number: O28927
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health