O28856 (RISC_ARCFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Riboflavin synthase
EC=2.5.1.9

Gene names

Name:	ribC
Ordered Locus Names:	AF_1416

Organism

Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [Reference proteome] [HAMAP]

Taxonomic identifier

224325 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus › Archaeoglobus fulgidus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.
Sequence similarities	Belongs to the DMRL synthase family.

Ontologies

Keywords
Biological process	Riboflavin biosynthesis
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	riboflavin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	riboflavin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	Riboflavin synthase		PRO_0000134859

Sequences

	Sequence		Length	Mass (Da)
	O28856 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: C64E3D55752A9F37	FASTA	153	17,083
	10 20 30 40 50 60 MKIGIADTTF SRINMGKIAI DELRKISSIP YERYTVPGIK DLPIAAKKLL EEKGCDIVIT 70 80 90 100 110 120 LGWVGGTQKD MLSYIVLSMG LVIVQLMTNK HVIDVTIHED EAEDEKTLMM VAENRVREHV 130 140 150 RNAVDLLVNP KRLQKLAGTG QRQGYPDVGP ILK

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000782 Genomic DNA. Translation: AAB89831.1.
PIR	G69426.
RefSeq	NP_070245.1. NC_000917.1.
3D structure databases
ProteinModelPortal	O28856.
SMR	O28856. Positions 2-140.
ModBase	Search...
Protein-protein interaction databases
STRING	224325.AF1416.
Protocols and materials databases
DNASU	1484640.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAB89831; AAB89831; AF_1416.
GeneID	1484640.
KEGG	afu:AF1416.
Phylogenomic databases
eggNOG	COG1731.
KO	K00793.
OMA	IVDTTFA.
ProtClustDB	PRK06455.
Enzyme and pathway databases
BioCyc	AFUL224325:GJBC-1447-MONOMER.
UniPathway	UPA00275; UER00405.
Family and domain databases
Gene3D	3.40.50.960. 1 hit.
InterPro	IPR002180. DMRL_synthase. IPR006399. Ribfl_synth_arc. [Graphical view]
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
TIGRFAMs	TIGR01506. ribC_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RISC_ARCFU

Accession

Primary (citable) accession number: O28856

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program