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Protein

Probable aquaporin AqpM

Gene

aqpM

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Channel that permits osmotically driven movement of water in both directions.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi1.A.8.13.1. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable aquaporin AqpM
Gene namesi
Name:aqpM
Ordered Locus Names:AF_1426
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
Proteomesi
  • UP000002199 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 56ExtracellularSequence analysisAdd BLAST23
Transmembranei57 – 77HelicalSequence analysisAdd BLAST21
Topological domaini78 – 104CytoplasmicSequence analysisAdd BLAST27
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 146ExtracellularSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 173CytoplasmicSequence analysis6
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 217ExtracellularSequence analysisAdd BLAST23
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 246CytoplasmicSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640071 – 246Probable aquaporin AqpMAdd BLAST246

Interactioni

Protein-protein interaction databases

STRINGi224325.AF1426.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 34Combined sources30
Beta strandi41 – 43Combined sources3
Turni47 – 52Combined sources6
Helixi53 – 78Combined sources26
Helixi84 – 91Combined sources8
Turni92 – 94Combined sources3
Helixi98 – 100Combined sources3
Helixi101 – 123Combined sources23
Helixi126 – 129Combined sources4
Helixi132 – 134Combined sources3
Helixi144 – 165Combined sources22
Helixi176 – 195Combined sources20
Helixi201 – 213Combined sources13
Helixi219 – 223Combined sources5
Helixi224 – 243Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NE2X-ray3.00A/B/C/D/E/F/G/H1-246[»]
ProteinModelPortaliO28846.
SMRiO28846.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO28846.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 85NPA 13
Motifi200 – 202NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
KOiK02440.
OMAiNIFFECA.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O28846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLAKRFT AEVVGTFILV FFGPGAAVIT LMIANGADKP NEFNIGIGAL
60 70 80 90 100
GGLGDWFAIG MAFALAIAAV IYSLGRISGA HINPAVTIAL WSIGRFPGRE
110 120 130 140 150
VVPYIVAQFI GAALGSLLFL ACVGPAAATV GGLGATAPFP GIGYGQAILT
160 170 180 190 200
EAIGTFLLML VIMGVAVDER APPGFAGLVI GLTVGGIITT IGNITGSSLN
210 220 230 240
PARTFGPYLG DSLMGINLWQ YFPIYVIGPI VGAVAAAWLY NYLAKE
Length:246
Mass (Da):25,212
Last modified:January 1, 1998 - v1
Checksum:i2CAE3D80B3BE97C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89820.1.
PIRiA69428.

Genome annotation databases

EnsemblBacteriaiAAB89820; AAB89820; AF_1426.
KEGGiafu:AF_1426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89820.1.
PIRiA69428.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NE2X-ray3.00A/B/C/D/E/F/G/H1-246[»]
ProteinModelPortaliO28846.
SMRiO28846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1426.

Protein family/group databases

TCDBi1.A.8.13.1. the major intrinsic protein (mip) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89820; AAB89820; AF_1426.
KEGGiafu:AF_1426.

Phylogenomic databases

eggNOGiarCOG04431. Archaea.
COG0580. LUCA.
KOiK02440.
OMAiNIFFECA.

Miscellaneous databases

EvolutionaryTraceiO28846.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAQPM_ARCFU
AccessioniPrimary (citable) accession number: O28846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.