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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1519-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:AF_1486
OrganismiArchaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Taxonomic identifieri224325 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaArchaeoglobiArchaeoglobalesArchaeoglobaceaeArchaeoglobus
ProteomesiUP000002199 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 471471Phosphoenolpyruvate carboxylasePRO_0000309598Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi224325.AF1486.

Structurei

3D structure databases

ProteinModelPortaliO28786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
KOiK01595.
OMAiQSSFKYD.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

O28786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPRVMSTQH PDNARIPFFA ASEVLNGEDE VREAYYVFSH FKCDEQMWDF
60 70 80 90 100
EGKEADAHIV RKLLSSYYDF FSSRPLGKDF RLTMRVPNPE IEKGEAKLLA
110 120 130 140 150
ETLEMIPRSY DYVRSLGIEH PPIFEVILPM TRSAEEVMKV HAFYRDFVAG
160 170 180 190 200
KGRFELLGEK VSDWLGDFLP EEIKVIPLFE DRDSLMRAAE ISERYAEWAE
210 220 230 240 250
LDELRVFLAR SDPAMNYGFV AATIYVKKAL YDLSQLGIST YPILGVGSCP
260 270 280 290 300
FRGGFSPKNL SVLDEFPSVY TFTVQSAFKY DYEFGDVRRA IKRAKEAARR
310 320 330 340 350
KSDYVDEEHL QVAEKLKDGY RRRIAKIAEI VNRISSRIPR RRMRKLHVGL
360 370 380 390 400
FGYSRGEEIK LPRAITFCAS LYSIGLPSEI IGIAEMSDKD YEAVCEVFKN
410 420 430 440 450
FDGMMESAMS LFNPESLKIV DLSMDFERAK ELFGYEPDER HLEKTNEIIK
460 470
QIDGDIKNLV VEAGILRGFL G
Length:471
Mass (Da):54,166
Last modified:December 31, 1997 - v1
Checksum:i892A03A47FBDA771
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89769.1.
PIRiE69435.
RefSeqiNP_070315.1. NC_000917.1.

Genome annotation databases

EnsemblBacteriaiAAB89769; AAB89769; AF_1486.
GeneIDi1484712.
KEGGiafu:AF1486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000782 Genomic DNA. Translation: AAB89769.1.
PIRiE69435.
RefSeqiNP_070315.1. NC_000917.1.

3D structure databases

ProteinModelPortaliO28786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224325.AF1486.

Protocols and materials databases

DNASUi1484712.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB89769; AAB89769; AF_1486.
GeneIDi1484712.
KEGGiafu:AF1486.

Phylogenomic databases

eggNOGiCOG1892.
KOiK01595.
OMAiQSSFKYD.

Enzyme and pathway databases

BioCyciAFUL224325:GJBC-1519-MONOMER.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus."
    Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G.
    , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C.
    Nature 390:364-370(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Entry informationi

Entry nameiCAPPA_ARCFU
AccessioniPrimary (citable) accession number: O28786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 12, 2007
Last sequence update: December 31, 1997
Last modified: February 3, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.