ID   IORA_ARCFU              Reviewed;         623 AA.
AC   O28783;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Indolepyruvate oxidoreductase subunit iorA;
DE            Short=IOR;
DE            EC=1.2.7.8;
DE   AltName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha;
GN   Name=iorA; OrderedLocusNames=AF_1489;
OS   Archaeoglobus fulgidus.
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales;
OC   Archaeoglobaceae; Archaeoglobus.
OX   NCBI_TaxID=2234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126;
RX   MEDLINE=98049343; PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E.,
RA   Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D.,
RA   Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C.,
RA   Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G., Gill S.R.,
RA   Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J.,
RA   Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A.,
RA   Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A.,
RA   Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P.,
RA   Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C.,
RA   Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O.,
RA   Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-
RT   reducing archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: Catalyzes the ferredoxin-dependent oxidative
CC       decarboxylation of arylpyruvates (By similarity).
CC   -!- CATALYTIC ACTIVITY: (Indol-3-yl)pyruvate + CoA + 2 oxidized
CC       ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced
CC       ferredoxin + H(+).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster.
CC   -!- SUBUNIT: Heterodimer of the iorA and iorB subunits.
CC   -!- SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.
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DR   EMBL; AE000782; AAB89760.1; -; Genomic_DNA.
DR   PIR; H69435; H69435.
DR   RefSeq; NP_070318.1; -.
DR   GeneID; 1484716; -.
DR   GenomeReviews; AE000782_GR; AF_1489.
DR   KEGG; afu:AF1489; -.
DR   NMPDR; fig|224325.1.peg.1479; -.
DR   TIGR; AF_1489; -.
DR   HOGENOM; O28783; -.
DR   OMA; O28783; VADDPSM.
DR   BioCyc; AFUL224325:AF_1489-MON; -.
DR   BRENDA; 1.2.7.8; 7576.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0043805; F:indolepyruvate ferredoxin oxidoreductase ac...; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamin pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR001450; 4Fe4S_Fe_S_bd_subgr.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017721; Indolepyruvate_Fd_OxRdtase_asu.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR011766; TPP_enzyme_bd_C.
DR   InterPro; IPR015941; Transketolase_C-like.
DR   Gene3D; G3DSA:3.40.50.920; Transketo_C_like; 1.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   TIGRFAMs; TIGR03336; IOR_alpha; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Oxidoreductase; Transport.
FT   CHAIN         1    623       Indolepyruvate oxidoreductase subunit
FT                                iorA.
FT                                /FTId=PRO_0000099925.
FT   DOMAIN      593    622       4Fe-4S ferredoxin-type.
FT   METAL       602    602       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       605    605       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       608    608       Iron-sulfur (4Fe-4S) (Potential).
FT   METAL       612    612       Iron-sulfur (4Fe-4S) (Potential).
SQ   SEQUENCE   623 AA;  67798 MW;  9B55E1CDC3860D56 CRC64;
     MLNDVVRDAE GEKVFLLGNE AIARGAIEAG IDVFAAYPGT PSSEIADTLS DACRLLRGKM
     DFYMEYSANE KVAFEVAVGA SLAGKRAMAT MKHVGVNVAA DPLFSFAYVG ARGGFVLVTA
     DDPSMHSSQN EQDNRWYGKA AKLPVVEPSS VQEAKDYAKL CFDLSEKFGL PMILRSYTRL
     SHASGVVELG KIPEKEFSRV EWERHPETDV VLPAHARKLK PILLEKLEKI ERYFNSSEMN
     WVDEGDGDVG IIACGLSYAY TKEALENLNL NLPVLKLSSM HPLPERLIEN FVSQMKKVIV
     VEEVDPFVEL HVRAMGLAEV YGKMNGYMPM NYEYNVGRVE TGIAKALGIK PSRDYEGIVA
     ESQKLAAKAP PRPPVLCPGC PHSASFYAIR RVVDELGDAA LPSDIGCYTL GINKPLEGVD
     ITICMGASVG VSNGLAHVLN NKIIATIGDS TFIHAGIPPL INAVYNHADF VLVILDNSTT
     GMTGHQPHPG TGFRGCGEAG KAVRIEDIVR GCGVEFVEVV NPYNVRKMVD VLRRALNHDG
     VAVVIARQPC AILWSRARRR EGKIVTYKVT EDCTLCMECV NTFACPALIF DGEKVSIDQS
     LCVGCAVCAK ICPNRAIKPA KSN
//