Reviewed, UniProtKB/Swiss-Prot O28783 (IORA_ARCFU)

Names and origin

Protein names

Recommended name:
    Indolepyruvate oxidoreductase subunit iorA
      Short name=IOR
    EC=1.2.7.8
Alternative name(s):
    Indolepyruvate ferredoxin oxidoreductase subunit alpha

Gene names

Name:	iorA
Ordered Locus Names:	AF_1489

Organism

Archaeoglobus fulgidus [Complete proteome] [HAMAP]

Taxonomic identifier

2234 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates By similarity.
Catalytic activity	(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + 2 reduced ferredoxin + H+.
Cofactor	Binds 1 4Fe-4S cluster.
Subunit structure	Heterodimer of the iorA and iorB subunits.
Sequence similarities	Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro indolepyruvate ferredoxin oxidoreductase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	Indolepyruvate oxidoreductase subunit iorA		PRO_0000099925
Regions
	Domain	593 – 622	30	4Fe-4S ferredoxin-type
Sites
	Metal binding	602	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	605	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	608	1	Iron-sulfur (4Fe-4S) Potential
	Metal binding	612	1	Iron-sulfur (4Fe-4S) Potential

Sequences

	Sequence		Length	Mass (Da)
	O28783-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 9B55E1CDC3860D56	FASTA	623	67,798
	10 20 30 40 50 60 MLNDVVRDAE GEKVFLLGNE AIARGAIEAG IDVFAAYPGT PSSEIADTLS DACRLLRGKM 70 80 90 100 110 120 DFYMEYSANE KVAFEVAVGA SLAGKRAMAT MKHVGVNVAA DPLFSFAYVG ARGGFVLVTA 130 140 150 160 170 180 DDPSMHSSQN EQDNRWYGKA AKLPVVEPSS VQEAKDYAKL CFDLSEKFGL PMILRSYTRL 190 200 210 220 230 240 SHASGVVELG KIPEKEFSRV EWERHPETDV VLPAHARKLK PILLEKLEKI ERYFNSSEMN 250 260 270 280 290 300 WVDEGDGDVG IIACGLSYAY TKEALENLNL NLPVLKLSSM HPLPERLIEN FVSQMKKVIV 310 320 330 340 350 360 VEEVDPFVEL HVRAMGLAEV YGKMNGYMPM NYEYNVGRVE TGIAKALGIK PSRDYEGIVA 370 380 390 400 410 420 ESQKLAAKAP PRPPVLCPGC PHSASFYAIR RVVDELGDAA LPSDIGCYTL GINKPLEGVD 430 440 450 460 470 480 ITICMGASVG VSNGLAHVLN NKIIATIGDS TFIHAGIPPL INAVYNHADF VLVILDNSTT 490 500 510 520 530 540 GMTGHQPHPG TGFRGCGEAG KAVRIEDIVR GCGVEFVEVV NPYNVRKMVD VLRRALNHDG 550 560 570 580 590 600 VAVVIARQPC AILWSRARRR EGKIVTYKVT EDCTLCMECV NTFACPALIF DGEKVSIDQS 610 620 LCVGCAVCAK ICPNRAIKPA KSN

References

[1]

"The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus." Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A., Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L., Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D., Quackenbush J., Lee N.H., Sutton G.G. , Gill S.R., Kirkness E.F., Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N., Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R., Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D., Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P., Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M., Smith H.O., Woese C.R., Venter J.C. Nature 390:364-370(1997) [PubMed: 9389475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000782 Genomic DNA. Translation: AAB89760.1.
PIR	H69435.
RefSeq	NP_070318.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1484716.
GenomeReviews	Gene locus AF_1489 in contig AE000782_GR.
KEGG	afu:AF1489.
NMPDR	fig|224325.1.peg.1479.
TIGR	AF_1489.
Phylogenomic databases
HOGENOM	O28783.
OMA	O28783. VADDPSM.
Enzyme and pathway databases
BioCyc	AFUL224325:AF_1489-MON.
BRENDA	1.2.7.8. 7576.
Family and domain databases
InterPro	IPR017896. 4Fe4S_Fe-S-bd. IPR001450. 4Fe4S_Fe_S_bd_subgr. IPR017900. 4Fe4S_Fe_S_CS. IPR017721. Indolepyruvate_Fd_OxRdtase_asu. IPR002880. Pyrv_Fd/Flavodoxin_OxRdtase_N. IPR011766. TPP_enzyme_bd_C. IPR015941. Transketolase_C-like. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF00037. Fer4. 1 hit. PF01855. POR_N. 1 hit. PF02775. TPP_enzyme_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR03336. IOR_alpha. 1 hit.
PROSITE	PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IORA_ARCFU

Accession

Primary (citable) accession number: O28783

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)